Selfish gene

作者：  (英)理查德·道金斯(Richard Dawkins)著;卢允中[等]译

出版社：中信出版社,2012

简介：　　《自私的基因》是20世纪最经典的著作，是道金斯《自私的基因》三十周年纪念版，它在前版本基础上有一些增补和修订。我们从哪里来，又将到哪里去。生命有何意义，我们该如何认知自己？这本书充满想象力。任何生物，包括我们自己，都只是求生的机器。这本书是实实在在的认知科学，复制、变异和淘汰简单的三种机制可以演变出所有大千世界生命现象里的林林总总。 　　 道金斯在《自私的基因》中的突破性贡献在于，把根据自然选择的社会学说的这一重要部分，用简明通俗的形式，妙趣横生的语言介绍给大家，这是第一次。 他惊世骇俗地在《自私的基因》中提出：我们生来是自私的。人类窥见了社会关系中基本的对称性和逻辑性，在我们有了更充分的理解之后，我们的政治见解当会重新获得活力，并对心理学的科学研究提供理论上的支柱。在这一过程中，我们也必将对我们受苦受难的许多根源有一个更深刻的理解。 　　 读者对象：学生、白领、对生命充满好奇的人、读人类的进化和社会行为渴望了解的人，对道金斯学说了解和有兴趣的人。

UNIX Power Toos

作者：  [美]Jerry Peek等著;张志龙等译

出版社：中国电力出版社,2002

简介：　　 就其特性而言，UNIX是一个“超级工具（power1tool）”环境。即使是刚开始学习UNIX的用户也能够很快地领会到，在UNIX的shell编程、别名和历史机制以及不同的编辑工具中，蕴含着强大的功能。虽然如此，只有很少的用户能够真正掌握这种每个人都可以利用的功能。这都是因为有太多的东西需要学习了！ 　　如果你使用过UNIX，就会知道很多程序是可以在Internet上得到的。本书及附带的光盘中包含了我们认为对UNIX超级用户而言是最好的免费软件。它大约包含了几千个提示、脚本和技巧，这些都能够让UNIX变得更容易、更有效，甚至更有趣。它还提供了功能强大且免费的程序，从而提高了UNIX标准命令集的灵活性。每一个脚本和程序都可以在光盘上找到，因此你只需把它添加在你自己的超级工具集中即可。 　　 而且，如果你使用的是任何一种最常见的UNIX平台，那么你就不需要再编写软件了，因为它已经对Solaris、SunOS、DigitallUNIX、IBMlAIX、HP/UX、LinuxlIntel以及SCOlUNIX平台进行了预编译。（SCO1UNIX的二进制文件很可能也可以在其他IntellUNIX平台上运行。）本书所带光盘使用的是ISO-9660格式。可以将它安装为类似于一个UNIX文件系统，并用熟悉的命令浏览它（在使用其中的程序之前，你必须先把它安装在硬盘上，可以使用我们提供的智能安装程序）。 　　 本书系第二版。与第一版类似，第二版收集了很多UNIX专家的意见，许多内容精选自O'Reilly的畅销系列 —— UNIX技术手册丛书（Nutshell Handbooks on UNIX），本书作者均为UNIX方面的专家，包括：Jerry Peek、Tim O'Reilly、Dale Dougherty、Mike Loukides、Chris Torek、Bruce Barnett、Jonathan Kamens、Gene Spafford、Simson Garfinkel以及其他一些人。 　　 然而，该版本在很多重要的方面又有所不同。书中涉及的内容更多地倾向于POSIX实用程序，包括GNU版本。有关bash和tsch1shell的内容更加宽泛，但是我们也保留了第一版中关于sh和csh核心概念的重点介绍，这有助于你使用所有的UNIX1shell。我们也更新了第一版所附带光盘中的程序，添加了更多的脚本和程序，并结合了数以百计的读者的修改和建议。 　　

Molecular biology of the gene

作者：  (美)J. D.沃森(James D. Watson)[等]编著;杨焕明等译

出版社：科学出版社,2009

简介：　　 本书由DNA双螺旋的发现者之一——James D.Watson及其他几位著名学 　　者在第五版的基础上修订完成。本书除了反映分子生物学领域的最新进展 　　之外，还涉及其他诸多方面的内容。此次修订仍保留了上一版中的许多定 　　义和特点，而且新增了调控RNA和基因组分析以及系统生物学的内容。全书 　　共分五篇：化学和遗传学、基因组的维持、基因组的表达、调控以及方法 　　。 　　 本书具有权威性，内容新颖、详尽，堪称此领域的经典之作。为广大 　　的生物爱好者及研究人员提供了分子生物学的知识框架和实验途径，并强 　　调了基因科学对于整个生物领域的重要意义。 　　

Say it with charts complete toolkit

作者：  (美)基恩·泽拉兹尼(Gene Zelazny)著;马晓路，马洪德译

出版社：清华大学出版社,2008

简介：《用图表说话》是唯一一本从观众需求出发，将技巧和理念系统结合起来的书。关于报表的制作，演示的方法，我们似乎一直处于摸索的状态中。面对着左右手一般熟悉的EXCEL和PPT软件，大家都知道怎么把它做得很绚丽，但如何表现才最为有效，却总是缺乏一个权威的声音。于是我们不得不忍受事倍功半的视觉垃圾，忘记了“图表应该节省一千句话，而不是需要一千句话来解释”。《用图表说话》揭示了准备成功商业演示所必备的技能和技巧，教你怎样把信息和思想变成令人信服的有影响力的图表，使听众明白无误地理解你的意图。数百条有价值的技巧和方法可使你的演示生动有趣并产生轰动效应。花最少的时间，用最简单的方法直击问题的要害吧！

Molecular biology of the gene

作者：  (美)J. D. 沃森(James D. Watson)[等]编著;杨焕明等译

出版社：科学出版社,2005

简介：　　 本书由DNA双螺旋的发现者之一——James D．Watson及其他几位著名学者在第四版的基础上修订完成。本书除了反映分子生物学领域的最新进展之外，还涉及其他诸多方面的内容。此次修订仍保留了原书中的许多定义和特点，全书共分五篇：化学和遗传学、基因组的维持、基因组的表达、调控，以及全新内容的第五篇——方法。 　　 本书具有权威性，内容新颖、详尽，堪称此领域的经典之作。为广大的生物爱好者及研究人员提供了分子生物学的知识框架和实验途径，并强调了基因科学对于整个生物领域的重要意义。 　　

Biology : concepts & connections / 4th ed.

作者：  Neil A. Campbell ... [et al.]

出版社：

简介：Biology: Concepts and Connections invites readers into the world of biology with a new revision of this best-selling text. It is known for scientific accuracy and currency; a modular presentation that helps readers to focus on the main concepts; and art that teaches better than any other book. Biology: Exploring Life, THE LIFE OF THE CELL, The Chemical Basis of Life, The Molecules of Cells, A Tour of the Cell, The Working Cell, How Cells Harvest Chemical Energy, Photosynthesis: Using Light to Make Food, CELLULAR REPRODUCTION AND GENETICS, The Cellular Basis of Reproduction and Inheritance, Patterns of Inheritance, Molecular Biology of the Gene, The Control of Gene Expression, DNA Technology and Genomics, CONCEPTS OF EVOLUTION, How Populations Evolve, The Origin of Species, Tracing Evolutionary History, THE EVOLUTION OF BIOLOGICAL DIVERSITY, The Origin and Evolution of Microbial Life: Prokaryotes and Protists, Plants, Fungi, and the Colonization of Land, The Evolution of Animal Diversity, Human Evolution, ANIMALS: FORM AND FUNCTION, Unifying Concepts of Animal Structure and Function, Nutrition and Digestion, Gas Exchange, Circulation, The Immune System, Control of the Internal Environment, Chemical Regulation, Reproduction and Embryonic Development, Nervous Systems, The Senses, How Animals Move, PLANTS: FORM AND FUNCTION, Plant Structure, Reproduction, and Development, Plant Nutrition and Transport, Control Systems in Plants, ECOLOGY, The Biosphere: An Introduction to Earth's Diverse Environments, Behavioral Adaptations to the Environment, Population Dynamics, Communities and Ecosystems, Conservation Biology For all readers interested in the world of biology.

Visual developer creating Visual Basic 5 add-ins

作者：  (美)[G.斯沃茨费格]Gene Swartzfager著;健莲工作室译

出版社：机械工业出版社,1998

简介：　　本书叙述了visualbasic5所支持的插件开发的所有主要能力和特征。全书共分四大部分，即对插件的介绍、如何使用插件对象和成员、插件程序专题研究和插件词典。 　　 　　 　　

Molecular biology of the gene

作者：  J.D.沃森[等]编著;杨焕明等译

出版社：科学出版社,2009

简介：

The selfish gene

作者：  (英)里查德·道金斯(Richard Dawkins)著;卢允中等译

出版社：吉林人民出版社,1998

简介：　　虽然黑猩猩和人类的进化史大约有99.5%是共同的，但人类的大多数思想家把黑猩猩视为畸形异状、与人类毫不相干的怪物，而把他们自己看成是上升为万物之主的阶梯。对一个进化论者来说，情况绝非如此。认为某一物种比另一物种高尚是毫无客观依据的。不论是黑猩猩和人类，还是蜥蜴和真菌，他们都是经过长达约三十亿年之久的所谓自然选择这一过程进化而来。每一物种之内，某些个体比另一些个体留下更多的生存后代，因此，这些得以繁殖的幸运者的可遗传特性（基因），在其下一代中的数量就变得更加可观。基因的非随机性的区分繁殖就是自然选择。自然选择造就了我们，因此，要想了解我们的自身特性，就必须懂得自然选择。 　　尽管达尔文的自然选择进化学说是研究社会行为的关键所系（特别是同 　　孟德尔的遗传学相结合时），但却一直为许多人所忽视。社会科学领域内一系列研究部门相继兴起，致力于建立一种达尔文前和孟德尔前派的社会和心理世界的观点。甚至在生物学领域中，忽视和滥用达尔文学说的情况一直令人诧异。无论造成这种异常发展的原因究竟何在。有迹象表明，这种状况即将告终。达尔文和孟德尔所进行的伟大工作已为日渐增多的科学工作者所发展，其中著名者主要有菲希尔（R.A.Fisher），汉密尔顿（w.D.Hamilton），威廉斯（G.C.Williams）和史密斯（J.Maynard Smith）。现在，道金斯（Richard Dawkins）把根据自然选择的社会学说的这一重要部分，用简明通俗的形式介绍给大家，这是第一次。 　　道金斯对社会学说中这一崭新工作的主要论题逐一作了介绍：利他和利己行为的概念，遗传学上的自私的定义，进犯行为的进化，亲族学说（包括亲子关系和群居昆虫的进化），性比率学说；相互利他主义，欺骗行为和性差别的自然选择。道金斯精通这一基本理论，他胸有成竹，以令人钦佩的清晰文体展示了这一崭新的工作。由于他在生物学方面的造诣颇深，他能够使读者领略生物学文献中的丰富多彩和引人人胜之处。凡遇他的观点同已发表的著作的论点有分歧时，他的评论，就象他在指出我的一处谬误时一样，无不一箭中的。同时，道金斯不遗余力地把据以论证的逻辑推理交待清楚，俾使读者能够运用这种逻辑推理再去扩展这些论据（甚至可以和道金斯本人展开争论）。这些论据可以向许多方面扩展。例如，如果（按道金斯的论证）欺骗行为是动物间交往的基本活动的话，就一定存在有对欺骗行为的强烈的选择性，而动物也转而必须选择一定程度的自我欺骗，使某些行为和动机变成无意识的，从而不致因蛛丝马迹的自觉迹象，把正在进行的欺骗行为败露。因此，说自然选择有利于神经系统是更准确地反映了世界的形象这种传统观点，肯定是一种关于智力进化的非常幼稚的观点。 　　近年来社会学说方面取得了重大进展，由此引起了一股小小的逆流。例如，有人断言，近年来社会学说方面的这种进展，事实上是为了阻止社会前进的周期性阴谋的一部分，其方式是把这种社会的前进说成在遗传上似乎是不可能的。还有，把一些相似而又不堪一驳的观点罗致在一起，使人产生这样一种印象，即达尔文的社会学说，其政治含义是反动的。这种讲法同事实情况大有径庭。菲希尔和汉密尔顿首次清楚地证明了遗传上性别的均等性。从群居昆虫得到的理论和大量数据表明，亲代没有主宰其子代的固有趋势（反之亦然）。而且亲代投资和雌性选择的概念，为观察性别差异奠定了客观的和公正的基础，这是一个相当大的进展，超越了一般把妇女的力量和权利归根于毫无实际意义的生物学上的特性这一泥潭中所作的努力。总之，达尔文主义的社会学说使我们窥见了社会关系中基本的对称性和逻辑性，在我们有了更充分的理解之后，我们的政治见解当会重新获得活力，并对心理学的科学研究提供理论上的支柱。在这一过程中，我们也必将对我们受苦受难的许多根源有一个更深刻的理解。　　

Regulation of gene expression : molecular mechanisms /

作者：  by Gary H. Perdew, John P. Vanden Heuvel, Jeffrey M. Peters.

出版社：

简介："Regulation of Gene Expression: Molecular Mechanisms presents a comprehensive overview of methods and approaches for characterizing mechanisms of gene regulation. The text is appropriate both as a graduate textbook and a standard laboratory reference and provides the essential groundwork for an advanced understanding of the various mechanisms that may result in altered activityof a specific cell protein." "Each of three sections explores mechanisms of gene regulation and expression, andpresents methods and protocols for achieving specific experimental goals. Part I focuses on approaches for studying control of mRNA expression and determining targetgenes for a given transcription copy. Part II outlines themethods for determining how proteins can regulate each other by mediating synthesis, degradation, protein-proteininteractions, and posttranslational modification. Part IIIexplores how gene targeting techniques in mice can provideinsight into protein function. This volume provides a clear, concise overview of the protocols and techniques used to examine chemically or disease-mediate alterations in gene expression in mammalian systems."--BOOK JACKET

Softimage 3D design guide

作者：  (美)[B.拉夫]Barry Ruff，(美)[G.博迪奥]Gene Bodio著;张乃琳等译

出版社：机械工业出版社,1998

简介：　　Softimage由于其功能强大成为专业人员在建模、动画、纹理设计、光照以及渲染描 　　绘等领域中所选择的工具之一。本书通过三维动画项目的实际制作来详细地说明如何综合 　　运用Softimage的各项技术，高效率地创建令人叹为观止的三维造型与动画。通过本书中 　　的课程，读者将了解进行渲染、动画、建模、开发游戏，以及成功地制作最高质量材质的 　　各种途径。 　　本书是学习Softimage的一本优秀指南，可使读者在学习新技术时大大提高效率，尽 　　快掌握新技术的精髓和运用技巧。 　　Barry Ruffand Gene Bo出o：Softimage3D Design Guide 　　Authorizedtranslationfromthe English Languageedition Publishedby Coriolis Group，Inc. 　　Copyright1998by The Coriolis Group，Inc. 　　Allrightsreserved. 　　本书中文简体字版由机械工业出版社出版，未经出版者书面许可，本书的任何部分 　　不得以任何方式复制或抄袭。 　　版权所有，翻印必究。 　　　　

Fundamental molecular biology /

作者：  Lizabeth A. Allison.

出版社：

简介：Summary: Publisher Summary 1 Featuring full color illustrations throughout, this introductory textbook uses an accessible style to teach students the essential concepts of molecular biology. Allison (biology, College of William and Mary) employs mainly eukaryotic examples, but comparisons with prokaryotic organisms are made where appropriate. The CD-ROM contains downloadable artwork from the text as well as a sample interactive animation and tutorial. Annotation 漏2007 Book News, Inc., Portland, OR (booknews.com)   Publisher Summary 2 The author received the 2009 Outstanding Faculty Award, the Commonwealth of Virginia's highest honor for faculty, in January 2009.More accessible to beginning students in the field than its encyclopedic counterparts, Fundamental Molecular Biologyprovides a distillation of the essential concepts of molecular biology, and is supported by current examples, experimental evidence, an outstanding art program, multimedia support and a solid pedagogical framework. The text has been praised both for its balanced and solid coverage of traditional topics, and for its broad coverage of RNA structure and function, epigenetics and medical molecular biology.Focuses primarily on eukaryotic examples but includes key comparisons with prokaryotic organisms where it is appropriateIncludes all-original artwork providing the clearest possible insight into complex concepts. All artwork is available online and on CD-ROMSupplemented by outstanding student and instructor media resources including a CD-ROM that comes with every book and an interactive website at www.blackwellpublishing.com/allison featuring all artwork, animations of key processes, and useful student comprehension materialPedagogical boxes throughout explain additional concepts and topics in molecular biology: -TOOLS BOXESexplore key experimental methods and techniques in molecular biology -FOCUS BOXESoffer more detailed treatment of topics and delve into experimental strategies, historical background and areas for further exploration -DISEASE BOXESillustrate key principles of molecular biology by examining diseases that result from gene defectsVisit www.blackwellpublishing.com/allison to access helpful student and instructor resources online.Note:CD-ROM/DVD and other supplementary materials are not included as part of eBook file.  

DNA methylation microarrays : experimental design and statistical analysis /

作者：  Sun-Chong Wang, Arturas Petronis.

出版社：

简介：Summary: Publisher Summary 1 Wang (Systems Biology and Bioinformatics Institute, National Central U., Taiwan) and Petronis (Epigenetics Laboratory, Centre for Addiction and Mental Health, Canada) wrote this work to aid researchers and students in analyzing high throughput epigenomic data with sound statistics. The focus is on DNA methylation microarray data, but much of the analysis applies also to gene expression and histone modifications by chromatin immunoprecipitation on a chip. The first section introduces the basic statistics, describes the wet bench technologies producing the data for analysis, and preprocesses the data to remove systematic artifacts resulting from imperfection in the measurement. This normalized data is then subject to conventional hypothesis-driven analysis looking for differential methylated loci between populations, following which genomic tiling arrays are discussed. The next section concerns exploratory analysis and considers how the functions and roles of unannotated DNA elements are associated with those of known ones by cluster and network analysis. Final chapters discuss online annotations, public microarray data repositories, and open source software for microarray data analysis. The CD-ROM contains files of results plots discussed in the text and full-color versions of a number of images. Annotation 漏2008 Book News, Inc., Portland, OR (booknews.com)  

Genomic Perl : from bioinformatics basics to working code /

作者：  Rex A. Dwyer.

出版社：

简介：　　In this introduction to computational molecular biology, Rex Dwyer explains many basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, he covers the biological background for each problem, develops a model for the solution, and then introduces the Perl concepts needed to implement the solution. The chapters discuss pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. Concrete examples and a step-by-step approach enable readers to grasp the computational and statistical methods.　　

Tools for analysis of DNA and protein sequence data

作者：  薛庆中等编著

出版社：科学出版社,2009

简介：　　全书分9章。第1章，阐述序列比较的核心方法，即运用BLAST和ClustalX等工具做序列比对。第2章，重点介绍核苷酸序列分析工具，主要包括：基因可读框的识别，CpG岛、转录终止信号和启动子区域的预测分析，用mRNA序列预测基因等。第3章，介绍电子克隆的概念和具体操作方法。第4章，用MEGA4做分子进化遗传分析，绘制系统进化树，为研究基因进化打好基础。第5章，对蛋白质基本理化性质、二级结构、结构域和三维空间结构、预测目标蛋白的生物学功能等工具做逐一介绍。第6章，通过Gene Ontology和KEGG两个数据库，挖掘基因和蛋白质的功能并做代谢途径分析。第7章，利用X!Tandem软件鉴定蛋白质的串联质谱数据，进而预测蛋白质；同时借助TPP软件包进行蛋白质组学数据统计学分析，优化检索结果。第8章，使用TqVl4软件实现芯片的数据采集和标准化处理，并借助GenMAPP软件挖掘芯片数据的生物学意义。第9章，通过Cytoscape软件演示，介绍系统生物学分析概况，展示蛋白质-蛋白质相互作用，应用插件做网络结构分析。书后附有专业词中英文对照。 　　 本书是为从事生物学、医学、农学及计算机科学等领域研究的研究生、大学生、教师、医生、研究人员、计算机工作人员提供的通俗易学的手册和工具。

The regulatory genome : gene regulatory networks in development and evolution = 调控基因组 : 发育...

作者：  Eric H. Davidson.

出版社：

简介：

作者：  

出版社：

简介：Summary: Publisher Summary 1 Because stem cells can grow and divide indefinitely and can also differentiate into specialized cell types, they promise significant advances in regenerative medicine. Recent work has led to the development of new methods for embryonic and adult stem cell isolation, characterization, expansion in undifferentiated state, customized differentiation, efficient stem cell transduction for gene therapy, quick monitoring of rejection, and other advances. This volume, edited by Vemuri (Invitrogen Corporation), presents a sample of methodological advances for wider use by novice and expert scientists, including derivation of human embryonic stem cells in xeno-free conditions, digital imaging of stem cells by electron microscopy, controlled-cooling protocol for cryopreservation of human and non-human primate embryonic stem cells, cell surface markers in human embryonic stem cells, generation of a monoclonal antibody library against human embryonic stem cells, gene transfer via nucleofection into adult and embryonic stem cells, isolation of stem cells from human umbilical cord blood in serum-free conditions, hematopoietic colony-forming cell assays, assays for alloreactive responses by polymerase chain reaction, adenoviral transduction of mesechymal stem cells, and 13 others. As in the rest of the series, each chapter describes laboratory protocols, necessary materials, troubleshooting, and known pitfalls. Annotation 漏2008 Book News, Inc., Portland, OR (booknews.com)   Publisher Summary 2 The scope for improving health care using stem cell therapies is thrilling, but has considerable technical challenges and methodological constraints that need to be addressed. Keeping with the tradition of Humana Press to bring these developments to the forefront in a timely manner, this book presents scientific advances in stem cell methods for a wider use by novice and expert scientists, through the series of Methods in Molecular Biology.  

Molecular biology of the gene / 5th ed.

作者：  James D. Watson ... [et al.]

出版社：

简介：

作者：  

出版社：

简介：Summary: Publisher Summary 1 Scientists from around the world share laboratory protocols they use to study the disease characterized by reduced bone mass, quality, and strength. They include in vitro models to study bone cells and tissue, in vivo rodent models, gene delivery, molecular and genetic techniques, imaging techniques, and mechanical testing. The disk, which requires one of the major proprietary operating systems, contains color reproductions of illustrations in the text. Annotation 漏2008 Book News, Inc., Portland, OR (booknews.com)   Publisher Summary 2 The study of bone cells and tissues at the cellular and molecular levels in a variety of models has revolutionized the field. In this book, leading scientists from around the world share their step-by-step laboratory protocols for studying bone biology.聽This is the perfect guide for both new and experienced experimentalists attempting to study osteoporosis.  

作者：  

出版社：

简介：Summary: Publisher Summary 1 The editors of this book are affiliated with Cellumen, Inc. and Cellomics, Inc., the latter being the company that developed high contact screening (HCS), the high-throughput platform in discovery-driven research and development to analyze the functions of genes and gene products at the level of the cell. Current users and investigators considering implementing HCS in research and development are the intended audience of the 31 contributions, which discuss instrumentation, application software, reagents, and informatics as related to HCS. Some chapters comprise pure review on key topics, while others more specifically treat a method in HCS. Specific topics include: a pharmaceutical company user's perspective on the potential of HCS in drug discovery, characteristics and value of machine learning for imaging in HCS, and discovery of protein kinase phosphates inhibitors. Annotation 漏2006 Book News, Inc., Portland, OR (booknews.com)   Publisher Summary 2 High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell. High Content Screening: A Powerful Approach to Systems Cell Biology and Drug Discovery discusses its use as a high throughput platform to understand the functions of genes, RNA, proteins, and other cellular constituents at the level of the living cell.High Content Screening is assembled to assist both existing users of HCS, as well as investigators considering the addition of a discovery-driven platform to their research and development activities. The chapters have been organized into sections that highlight the importance of integrating instrumentation, application software, reagents, and informatics. In addition, there is a combination of pure review chapters on key topics and specific methods chapters. Written by a team of world leaders in the field, High Content Screening is essential reading for senior scientists, advanced lab technicians, as well as students/post-docs who wish to apply HCS in their research and development programs.