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Signal transduction = 信号转导 / 2nd ed.
光盘作者: Bastien D. Gomperts, IJsbrand M. Kramer, Peter E. R. Tatham..
简介: 作为有关细胞信号传递过程的一本书,《信号转导》(原著第二版)详 细介绍了确立近代和当前科学发现的起源、关键观察和实验。作者从历史 概况谈起,讲述了化学信使的概念如何在20世纪初期产生并逐渐形成目前 对激素、细胞因子、神经递质和生长因子作用的理解。之后,进一步介绍 了由经典受体(如黏附分子)产生的复杂信号级联反应,这些信号参加了视 觉、嗅觉、炎症、先天免疫和适应性免疫、葡萄糖稳态调控、细胞命运决 定、细胞分化和细胞转化等过程。最后,讨论了针对性地干预转导通路来 治疗癌症和组装信号复合体的蛋白结构域。 本书是一本非常有价值的参考书,适合生物化学与分子生物学、细胞 生物学等相关专业的高年级本科生、研究生阅读,也可作为高校相关专业 教师的教学和科研参考书,亦可供生物医学、药理学、免疫学及相关领域 的研究人员参考。
作者: Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R. Tatham.
简介:《信号转导》是关于细胞信号传递过程的一本书。从基本概念开始,它介绍了细胞怎样对外界刺激(激素、细胞因子、神经递质、粘附分子、细胞外基质等)作出反应,这些输入信号如何进行整合和协调。本书的前半部分介绍了基本概念,解释了第二信使(特别是环核苷酸和钙)的形成和作用,以及GTP-结合蛋白介导的信号通路。其他章节涉及细胞因子和粘附分子介导的复杂信号级联的形成:始于质膜,终于细胞核来调控基因表达。在此意义上,生长是一个重要的结果,与癌变过程中的细胞转化有关。本书的结尾在分子水平上描述了信号分子怎样与它们所处的环境相互作用,信号分子之间又是如何通过结构域相连的。每个主题都由一篇历史性随笔引出,并大量引用参考文献,对关键实验和观察进行了详细描述,可使读者了解最前沿的研究工作。 从始至终,作者面对争论,挑战教条,对模棱两可的论点进行了讨论,而页边的注释又添加了本书的趣味性。 主要特色: 文字紧凑、精确,深度剖析了信号转导这一主题,此主题既是细胞生物学的中心,也是许多生物医学领域的基础。 大量的图片有助于对概念性内容的理解。 阅读拓展材料为核心文献和历史性文献提供了非常有价值的连接。 页边的注释标出了我们在了解信号传递机制过程中的里程碑。
Penguin Chick 自然科学启蒙2:小企鹅ISBN9780064452069
作者: Tatham
简介:
An emperor penguin lays an egg on the Antarctic ice. In thebitter cold, miles away from the only source of food, how can thechick survive?
【媒体评论】
Children's Literature This fine entry in the "Let's Read andFind Out" series explores the Emperor penguin species living onAntarctica pack ice. In informative and simple prose, Tatham tellshow these penguins nest, incubate the single egg, take turns eatingand caring for the egg and chick, and exhibit typical penguinbehavior such as tobogganing and huddling in creches. There is nomention of penguin predators such as Orcas and leopard seals butsmall pictures show the kinds of food penguins eat. In addition,there is a modest chart which compares chick growth over a year andback matter which gives information about five of the seventeenpenguin species and includes advice for walking and tobogganinglike a penguin. Davie's artful and attractive watercolorillustrations show necessary details interestingly. Sandra Markle'salso excellent Penguins (Growing Up Wild) (Atheneum, 2002) coverssome of the same generic information about penguins but discussesAdelie penguin behavior instead, features an index and glossary,something about predators, and is aimed at a slightly older readers2002, HarperCollins, $15.95. Ages 5 to 9. Reviewer: Susan HeplerSchool Library Journal Gr 1-3-This title focuses on one emperorpenguin family's survival. The parents' care of their young iscentral, shown by deft yet perfunctory watercolors depicting aharsh, challenging habitat. The danger of the baby's starvation isemphasized; one adult must keep it protected from the elements andthe other must fish for food and return in time to feed it beforeit dies. Trading places, the caregivers share these duties untilthe chick is old enough for both adult birds to hunt for foodtogether. A summary of a penguin's life up to the laying of an eggis followed by a section that describes the egg laying and nestingpatterns of kings, Ad lies, rockhoppers, jackasses, and littleblues. Brenda Guiberson's The Emperor Lays an Egg (Holt, 2001) andMartin Jenkins's The Emperor's Egg (Candlewick, 1999) will havewider appeal because of their sparkling language and vibrant art.This book's value rests on its accessibility to beginningreaders.-Nancy Call, Santa Cruz Public Libraries, Aptos, CACopyright 2001 Cahners Business Information. Fewer Reviews KirkusReviews Newcomer Tatham offers a clearly written, well-researchedchronicle of a penguin's growth cycle from egg to young adult inthis Stage 2 addition to the ever-reliable Let's-Read-and-Find-OutScience series. The chronological narrative uses short butinteresting sentences to describe the loving care of the penguinparents and the varied sounds the birds use to communicate. Theattractive design includes large illustrations on every page, withtext blocks often set on colored backgrounds integrated into theart. Davie's (The Night Rainbow, 2000, etc.) illustrations show thepenguins in motion (swimming, sliding, and waddling along in theirpeculiarly penguinesque way), as well as standing stoically againstswirls of spatter-painted snow. An author's note offers detailsabout several kinds of penguins and penguin movement. Guiberson'sThe Emperor Lays an Egg (p. 1549) covers similar frozen ground withmore notable illustrations, but with a longer text that isn't asaccessible to young readers. (Picture book/nonfiction. 5-9)
Elastomeric proteins : structures, biomechanical properties, and biological roles /
作者: edited by Peter R. Shewry, Arthur S. Tatham, Allen J. Bailey.
简介:Summary: Publisher Summary 1 Comparison of structures and mechanisms of elastic proteins in relation to their biological roles. Publisher Summary 2 Elastic proteins occur in a wide range of biological systems where they have evolved to fulfill precise biological roles. The best known include proteins in vertebrate muscles and connective tissues, such as titin, elastin, fibrillin and spider silks. Interest in elastomeric proteins is currently high for several reasons. Firstly, they have biological and medical significance, particularly in human disease. Secondly, the unusual properties of proteins such as spider silks provide opportunities to develop novel materials. Thirdly, the development of scanning probe microscopy makes it possible to study structures and biomechanical properties of these proteins at the single molecule level.
Developments in speech synthesis /
作者: Mark Tatham, Katherine Morton.
简介:"Contemporary speech synthesis is perceived as inadequate for general adoption for user interaction, largely because it rests on an inadequate model of human speech production and perception. This book reviews the underlying model, brings out areas of inadequacy and suggests how improvements might be made. It is argued that a greater understanding of the fine detail of speech will enable new research and application initiatives. The authors draw on their extensive experience in both theoretical and applied research to bring forward proposals for producing more natural sounding synthetic speech." "Developments in Speech Synthesis provides the basis for a comprehensive approach that will appeal to speech synthesis and language technology engineers specialising in building dialogue systems. It will also be a resource for computer science and engineering students at both advanced undergraduate and postgraduate levels, as well as researchers in the general field of speech synthesis."--BOOK JACKET.
作者: Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R. Tatham.
简介:Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention * In-depth coverage of nuclear receptors, including steps in isolation of steriod hormones and the discovery of intracellular hormone receptors; Tyrosine protein kinases and adaptive immunity; and intracellular calcium * Extensive conceptual colour artwork to assist with comprehension of key topics * Instrumental margin notes highlight milestones in signalling mechanisms DESCRIPTION:Signal Transduction is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics,this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction serves as an invaluable resource for advanced undergraduates, graduate researchers,and established scientists working in cell biology, pharmacology, immunology, and related fields.









