Molecular infection biology : interactions between microorganisms and cells /

作者：  edited by J鑟rg Hacker, J鑥rgen Heesemann.

出版社：

简介：Summary: Publisher Summary 1 Eleven researchers ten German and one from the U.S. examine the molecular mechanisms used by traditional and newly emerged pathogens to cause disease. Coverage includes medically significant pathogens; nonspecific defenses against microorganisms; the adaptive immune system; symbiosis, infection, and pathogenicity; offensive, defensive, and nonspecific pathogenicity factors; protein secretion systems; microbial surface variation and pathogenicity; regulation of virulence-associated genes; infection ecology; plant and human pathogen parallels; evolutionary infection biology; cellular microbiology; in vivo expression of pathogenicity; genomics, transcriptomics, and proteomics; molecular diagnosis and epidemiology; therapeutic problems with infections diseases; vaccine development; infection models; and molecular infection biology methods. Originally published as Molekulare Infektionsbiologie (Spektrum Akademishcer Verlag, 2000). Translated from German by Renate FitzRoy. Annotation c. Book News, Inc., Portland, OR (booknews.com)   Publisher Summary 2 This comprehensive volume focuses on molecular methods and principles of prokaryotic and eukaryotic pathogens. The authors present the molecular and cellular aspects by focusing on the interactions between pathogenic microorganisms and their hosts. The publication begins with an overview of the most important and dangerous causative agents of infectious diseases. Next are discussions of how microbial "weapons," pathogenicity factors, proteinsecretion machines, and surface variation systems work, presenting the molecular and genetic methods that are used by scientists for their discovery and analysis. Furthermore, infectious diseases are discussed in light of the newly formed research areas of evolutionary and cellular microbiology and genomics. Future aspects on diagnostic techniques, therapy, and vaccine development are also presented.