Decoding the genomic control of immune reactions /

作者：  [editors, Gregory Bock and Jamie Goode].

出版社：

简介：Judging from this collection of reports on recent research, great progress is being made toward using the genome sequences of humans, mice and other vertebrates to solve key problems in immunological disease and chronic infections. However, researchers are finding a barrier in the identification of key sequences and circuits controlling the relevant immune reactions. Drawn from material presented at the Novartis Foundation Symposium entitled "Decoding the Genomic Control of Immune Reactions" held in Canberra in March 2006, this collection covers transcriptional regulatory networks in macrophages, molecular pathways and their role in human disease, specifying the patterns of immune cell migration, human monogenic disorders and their relationship with specific infections, the genetic control of susceptibility to a strain of tuberculosis, disorders resulting from defective LAT signalosomes, smallpox and mousepox, strategies for phenotype detection and subsequent mapping and cloning, genetic control of host-pathogen interactions, systems genetics, and regulation of the immune system. Annotation 漏2007 Book News, Inc., Portland, OR (booknews.com)