Decoding the genomic control of immune reactions /
副标题：无
作 者：[editors, Gregory Bock and Jamie Goode].
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ISBN：9780470027554
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简介
Judging from this collection of reports on recent research, great progress is being made toward using the genome sequences of humans, mice and other vertebrates to solve key problems in immunological disease and chronic infections. However, researchers are finding a barrier in the identification of key sequences and circuits controlling the relevant immune reactions. Drawn from material presented at the Novartis Foundation Symposium entitled "Decoding the Genomic Control of Immune Reactions" held in Canberra in March 2006, this collection covers transcriptional regulatory networks in macrophages, molecular pathways and their role in human disease, specifying the patterns of immune cell migration, human monogenic disorders and their relationship with specific infections, the genetic control of susceptibility to a strain of tuberculosis, disorders resulting from defective LAT signalosomes, smallpox and mousepox, strategies for phenotype detection and subsequent mapping and cloning, genetic control of host-pathogen interactions, systems genetics, and regulation of the immune system. Annotation 漏2007 Book News, Inc., Portland, OR (booknews.com)
目录
Chair's Introduction Chris Goodnow p. 1
Transcriptional regulatory networks in macrophages David A. Hume and Christine A. Wells and Timothy Ravasi p. 2
Discussion p. 18
The RIKEN mouse transcriptome: lessons learned and implications for the regulation of immune reactions Christian Schonbach p. 25
Discussion p. 34
Molecular pathways for lymphangiogenesis and their role in human disease Steven A. Stacker and Rae H. Farnsworth and Tara Karnezis and Ramin Shayan and Darrin P. Smith and Karri Paavonen and Natalia Davydova and Carol Caesar and Rachael Inder and Megan E. Baldwin and Bradley K. McColl and Sally Roufail and Richard A. Williams and Richard A. Hughes and Kari Alitalo and Marc G. Achen p. 38
Discussion p. 44
General discussion I p. 50
Specifying the patterns of immune cell migration Jason G. Cyster p. 54
Discussion p. 61
Human monogenic disorders that center predisposition to specific infections Capucine Picard and Laurent Abel and Jean-Laurent Casanova p. 65
Discussion p. 73
The generic control of susceptibility to Mycobacterium tuberculosis W. J. Britton and S. L. Fernando and B. M. Saunders and R. Sluyter and J. S. Wiley p. 79
Discission p. 89
Th2 lymphoproliferative disorders resulting from defective LAT signalosomes Bernard Malissen and Ying Wang and Michael Mingueneau and Marie Malissen p. 93
Discussion p. 100
Genetic analysis of systematic autoimmunity Carola G. Vinuesa and Matthew C. Cook p. 103
Discussion p. 120
Genetic resistance to smallpox: lessons from mousepox Gunasegaran Karupiah and Vijay Panchanathan and Isaac G. Sakala and Geeta Chaudhri p. 129
Discussion p. 136
The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes Anny Fortin and Eduardo Diez and Janet E. Henderson and Jeffrey S. Mogil and Philippe Gros and Emil Skamene p. 141
Discussion p. 153
Genetic control of host-pathogen interactions in mice Gundula Min-Oo and Mary M. Stevenson and Anny Fortin and Philippe Gros p. 156
Discussion p. 165
Mycobacterium tuberculosis and its ability to resist immunity Douglas Young and Anne O'Garra p. 169
Discussion p. 177
Systems genetics: the next generation in generics research? Grant Morahan and Robert W. Williams p. 181
Discussion p. 188
Regulation of the immune system in metazoan parasite infections Rick Maizels p. 192
Discussion p. 204
Closing remarks Chris Goodnow p. 208
Contributor Index p. 210
Subject Index p. 212
Transcriptional regulatory networks in macrophages David A. Hume and Christine A. Wells and Timothy Ravasi p. 2
Discussion p. 18
The RIKEN mouse transcriptome: lessons learned and implications for the regulation of immune reactions Christian Schonbach p. 25
Discussion p. 34
Molecular pathways for lymphangiogenesis and their role in human disease Steven A. Stacker and Rae H. Farnsworth and Tara Karnezis and Ramin Shayan and Darrin P. Smith and Karri Paavonen and Natalia Davydova and Carol Caesar and Rachael Inder and Megan E. Baldwin and Bradley K. McColl and Sally Roufail and Richard A. Williams and Richard A. Hughes and Kari Alitalo and Marc G. Achen p. 38
Discussion p. 44
General discussion I p. 50
Specifying the patterns of immune cell migration Jason G. Cyster p. 54
Discussion p. 61
Human monogenic disorders that center predisposition to specific infections Capucine Picard and Laurent Abel and Jean-Laurent Casanova p. 65
Discussion p. 73
The generic control of susceptibility to Mycobacterium tuberculosis W. J. Britton and S. L. Fernando and B. M. Saunders and R. Sluyter and J. S. Wiley p. 79
Discission p. 89
Th2 lymphoproliferative disorders resulting from defective LAT signalosomes Bernard Malissen and Ying Wang and Michael Mingueneau and Marie Malissen p. 93
Discussion p. 100
Genetic analysis of systematic autoimmunity Carola G. Vinuesa and Matthew C. Cook p. 103
Discussion p. 120
Genetic resistance to smallpox: lessons from mousepox Gunasegaran Karupiah and Vijay Panchanathan and Isaac G. Sakala and Geeta Chaudhri p. 129
Discussion p. 136
The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes Anny Fortin and Eduardo Diez and Janet E. Henderson and Jeffrey S. Mogil and Philippe Gros and Emil Skamene p. 141
Discussion p. 153
Genetic control of host-pathogen interactions in mice Gundula Min-Oo and Mary M. Stevenson and Anny Fortin and Philippe Gros p. 156
Discussion p. 165
Mycobacterium tuberculosis and its ability to resist immunity Douglas Young and Anne O'Garra p. 169
Discussion p. 177
Systems genetics: the next generation in generics research? Grant Morahan and Robert W. Williams p. 181
Discussion p. 188
Regulation of the immune system in metazoan parasite infections Rick Maizels p. 192
Discussion p. 204
Closing remarks Chris Goodnow p. 208
Contributor Index p. 210
Subject Index p. 212
Decoding the genomic control of immune reactions /
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