G1 phase progression /

作者：  [edited by] Johannes Boonstra.

出版社：

简介：Summary: Publisher Summary 1 Focusing on the G1 phase, international molecular biologists and other specialists describe current research on the molecular networks that regulate cell cycle progression. Boonstra (molecular cell biology, U. Utrecht, The Netherlands) edits 13 chapters covering topics including description of individual molecules forming the network, including cyclins, cyclin-dependent kinases, and inhibitors of kinases and retinoblastoma; signaling cascades influencing the cell cycle network, including mitogens and oxygen radicals; the effects of external conditions such as serum starvation and stress; and the relationship between cell cycle progression and cell differentiation, and apoptosis. Annotation (c) Book News, Inc., Portland, OR (booknews.com)   Publisher Summary 2 In this contribution, several specialists describe the current knowledge on the molecular networks that regulate cell cycle progression, with an emphasis on the G1 phase of the cell cycle. The first part of Regulation of G1 Phase Progression is concerned with the individual molecules that form the network, including cyclins, cyclin-dependent kinases, inhibitors of these kinases and retinoblastoma and p53. The second section describes the signaling cascades by which external factors influence the cell cycle network, including mitogens, the extracellular matrix, nutrients and oxygen radicals. The last section describes the effects of specific external conditions on cell cycle progression and are presented such as serum starvation and subsequent re-addition and stress conditions (heat, osmolarity). The final two chapters describe the relation between cell cycle progression with cell differentiation and with apoptosis.