Sequence-specific DNA binding agents /

作者：  edited by Michael Waring.

出版社：

简介：These eleven chapters assembled by Waring (pharmacology, U. of Cambridge, UK) were written by senior scientists on diverse aspects on the binding of drugs and antibiotics to sequence-specific DNA. Topics include DNA recognition by triple helix formation, interfacial inhibitors of human topoisomerase I, diversity of topoisomerase I inhibitors for cancer chemotherapy, slow DNA binding, DNA gene targeting using peptide nucleic acid, thermal denaturation of drug-DNA complexes, computer simulations of drug-DNA interactions, the discovery of G-quadruplex telomere targeting drugs, the mechanism of action of telomestatin (a G-quadruplex interactive compound), and structural features of the specific interactions between nucleic acids and small organic molecules. Also included is a more historical paper describing sixty rears of research in characterizing the sequence-selective DNA-binding agent, actinomycin D. Annotation 漏2007 Book News, Inc., Portland, OR (booknews.com)