Table Of Contents:
Summaries of Chapters e1 to e57 xx
Contributors xxv
Preface xiiii

PART 1 Introduction to Clinical Medicine

1 The Practice of Medicine 2(7)

The Editors

2 Global Issues in Medicine 9(10)

Jim Yong Kim

Paul Farmer

Joseph Rhatigan

3 Decision-Making in Clinical Medicine 19(10)

Daniel B. Mark

John B. Wong

4 Screening and Prevention of Disease 29(4)

Gary J. Martin

5 Principles of Clinical Pharmacology 33(17)

Dan M. Roden

6 Women's Health 50(5)

Andrea Dunaif

7 Medical Disorders During Pregnancy 55(7)

Robert L. Barbieri

John T. Repke

8 Medical Evaluation of the Surgical Patient 62(5)

Wei C. Lau

Kim A. Eagle

9 Palliative and End-of-Life Care 67(18)

Ezekiel J. Emanuel

10 The Safety and Quality of Health Care 85(8)

David W. Bates

e1 Primary Care in Low- and Middle-Income Countries

Tim Evans

Kumanan Rasanathan

e2 Complementary, Alternative, and Integrative Medicine

Josephine P. Briggs

Stephen E. Straus

e3 The Economics of Medical Care

Joseph P. Newhouse

e4 Racial and Ethnic Disparities in Health Care

Joseph R. Betancourt

Alexander R. Green

e5 Ethical Issues in Clinical Medicine

Bernard Lo

e6 Neoplasia During Pregnancy

Dan L. Longo

PART 2 Cardinal Manifestations and Presentation of Diseases

Section 1 Pain

11 Pain: Pathophysiology and Management 93(9)

James P. Rathmell

Howard L. Fields

12 Chest Discomfort 102(6)

Thomas H. Lee

13 Abdominal Pain 108(4)

William Silen

14 Headache 112(17)

Peter J. Goadsby

Neil H. Raskin

15 Back and Neck Pain 129(14)

John W. Engstrom

Richard A. Deyo

Section 2 Alterations in Body Temperature

16 Fever and Hyperthermia 143(5)

Charles A. Dinarello

Reuven Porat

17 Fever and Rash 148(10)

Elaine T. Kaye

Kenneth M. Kaye

e7 Atlas of Rashes Associated With Fever

Kenneth M. Kaye

Elaine T. Kaye

18 Fever of Unknown Origin 158(7)

Jeffrey A. Gelfand

Michael V. Callahan

19 Hypothermia and Frostbite 165(6)

Daniel F. Danzl

Section 3 Nervous System Dysfunction

20 Syncope 171(7)

Roy Freeman

21 Dizziness and Vertigo 178(3)

Mark F. Walker

Robert B. Daroff

22 Weakness and Paralysis 181(5)

Michael J. Aminoff

23 Numbness, Tingling, and Sensory Loss 186(6)

Michael J. Aminoff

Arthur K. Asbury

24 Gait and Balance Disorders 192(4)

Lewis Sudarsky

e8 Video Library of Gait Disorders

Gail Kang

Nicholas B. Galifianakis

Michael Geschwind

25 Confusion and Delirium 196(6)

S. Andrew Josephson

Bruce L. Miller

26 Aphasia, Memory Loss, and Other Focal Cerebral Disorders 202(11)

M.-Marsel Mesulam

e9 Memory Loss

Bruce L. Miller

Indre V. Viskontas

e10 Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders

Maria Luisa Gorno-Tempini

Jennifer Ogar

Joel Kramer

Bruce Miller

Gil Rabinovici

Maria Carmela Tartaglia

27 Sleep Disorders 213(11)

Charles A. Czeisler

John W. Winkelman

Gary S. Richardson

Section 4 Disorders of Eyes, Ears, Nose, and Throat

28 Disorders of the Eye 224(17)

Jonathan C. Horton

e11 Video Library of Neuro-Ophthalmology

Shirley H. Wray

29 Disorders of Smell and Taste 241(7)

Richard L. Doty

Steven M. Bromley

30 Disorders of Hearing 248(7)

Anil K. Lalwani

31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections 255(12)

Michael A. Rubin

Larry C. Ford

Ralph Gonzales

32 Oral Manifestations of Disease 267(10)

Samuel C. Durso

e12 Atlas of Oral Manifestations of Disease

Samuel C. Durso

Janet A. Yellowitz

Section 5 Alterations in Circulatory and Respiratory Functions

33 Dyspnea 277(5)

Richard M. Schwartzstein

34 Cough and Hemoptysis 282(5)

Patricia Kritek

Christopher Fanta

35 Hypoxia and Cyanosis 287(3)

Joseph Loscalzo

36 Edema 290(5)

Eugene Braunwald

Joseph Loscalzo

e13 Approach to the Patient With a Heart Murmur

Patrick T. O'Gara

Joseph Loscalzo

37 Palpitations 295(2)

Joseph Loscalzo

Section 6 Alterations in Gastrointestinal Function

38 Dysphagia 297(4)

Ikuo Hirano

Peter J. Kahrilas

39 Nausea, Vomiting, and Indigestion 301(7)

William L. Hasler

40 Diarrhea and Constipation 308(12)

Michael Camilleri

Joseph A. Murray

41 Gastrointestinal Bleeding 320(4)

Loren Laine

42 Jaundice 324(6)

Daniel S. Pratt

Marshall M. Kaplan

43 Abdominal Swelling and Ascites 330(4)

Kathleen E. Corey

Lawrence S. Friedman

Section 7 Alterations in Renal and Urinary Tract Function

44 Azotemia and Urinary Abnormalities 334(7)

Julie Lin

Bradley M. Denker

e14 Atlas of Urinary Sediments and Renal Biopsies

Agnes B. Fogo

Eric G. Neilson

45 Fluid and Electrolyte Disturbances 341(19)

David B. Mount

e15 Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples

David B. Mount

Thomas D. DuBose, Jr.

46 Hypercalcemia and Hypocalcemia 360(3)

Sundeep Khosla

47 Acidosis and Alkalosis 363(11)

Thomas D. DuBose, Jr.

Section 8 Alterations in Sexual Function and Reproduction

48 Sexual Dysfunction 374(6)

Kevin T. McVary

49 Hirsutism and Virilization 380(4)

David A. Ehrmann

50 Menstrual Disorders and Pelvic Pain 384(5)

Janet E. Hall

Section 9 Alterations in the Skin

51 Approach to the Patient With a Skin Disorder 389(6)

Thomas J. Lawley

Kim B. Yancey

52 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders 395(10)

Leslie P. Lawley

Calvin O. McCall

Thomas J. Lawley

53 Skin Manifestations of Internal Disease 405(19)

Jean L. Bolognia

Irwin M. Braverman

54 Immunologically Mediated Skin Diseases 424(8)

Kim B. Yancey

Thomas J. Lawley

55 Cutaneous Drug Reactions 432(8)

Kanade Shinkai

Robert S. Stern

Bruce U. Wintroub

56 Photosensitivity and Other Reactions to Light 440(8)

Alexander G. Marneros

David R. Bickers

e16 Atlas of Skin Manifestations of Internal Disease

Thomas J. Lawley

Robert A. Swerlick

Section 10 Hematologic Alterations

57 Anemia and Polycythemia 448(9)

John W. Adamson

Dan L. Longo

58 Bleeding and Thrombosis 457(8)

Barbara Konkle

59 Enlargement of Lymph Nodes and Spleen 465(7)

Patrick H. Henry

Dan L. Longo

60 Disorders of Granulocytes and Monocytes 472(14)

Steven M. Holland

John I. Gallin

e17 Atlas of Hematology and Analysis of Peripheral Blood Smears

Dan L. Longo

PART 3 Genes, the Environment, and Disease

61 Principles of Human Genetics 486(23)

J. Larry Jameson

Peter Kopp

62 Chromosome Disorders 509(10)

Stuart Schwartz

Terry Hassold

63 The Practice of Genetics in Clinical Medicine 519(7)

Susan Miesfeldt

J. Larry Jameson

e18 Mitochondrial DNA and Heritable Traits and Diseases

Karl Skorecki

Hanna Mandel

64 The Human Microbiome 526(10)

Jeffrey I. Gordon

Rob Knight

e19 Systems Biology in Health and Disease

Joseph Loscalzo

PART 4 Regenerative Medicine

65 Stem Cell Biology 536(3)

Minoru S. H. Ko

66 Hematopoietic Stem Cells 539(4)

David T. Scadden

Dan L. Longo

67 Applications of Stem Cell Biology in Clinical Medicine 543(4)

John A. Kessler

68 Gene Therapy in Clinical Medicine 547(5)

Katherine A. High

69 Tissue Engineering 552(4)

David M. Hoganson

Howard I. Pryor, II

Joseph P. Vacanti

PART 5 Aging

70 World Demography of Aging 556(6)

Richard Suzman

John G. Haaga

71 The Biology of Aging 562(8)

George M. Martin

72 Clinical Problems of Aging 570(18)

Luigi Ferrucci

Stephanie Studenski

PART 6 Nutrition

73 Nutrient Requirements and Dietary Assessment 588(6)

Johanna Dwyer

74 Vitamin and Trace Mineral Deficiency and Excess 594(11)

Robert M. Russell

Paolo M. Suter

75 Malnutrition and Nutritional Assessment 605(7)

Douglas C. Heimburger

76 Enteral and Parenteral Nutrition Therapy 612(10)

Bruce R. Bistrian

David F. Driscoll

77 Biology of Obesity 622(7)

Jeffrey S. Flier

Eleftheria Maratos-Flier

78 Evaluation and Management of Obesity 629(7)

Robert F. Kushner

79 Eating Disorders 636(5)

B. Timothy Walsh

Evelyn Attia

80 Involuntary Weight Loss 641(5)

Russell G. Robertson

J. Larry Jameson

PART 7 Oncology and Hematology

Section 1 Neoplastic Disorders

81 Approach to the Patient With Cancer 646(9)

Dan L. Longo

82 Prevention and Early Detection of Cancer 655(8)

Jennifer M. Croswell

Otis W. Brawley

Barnett S. Kramer

83 Cancer Genetics 663(9)

Pat J. Morin

Jeffrey M. Trent

Francis S. Collins

Bert Vogelstein

84 Cancer Cell Biology and Angiogenesis 672(17)

Dan L. Longo

85 Principles of Cancer Treatment 689(23)

Edward A. Sausville

Dan L. Longo

86 Infections in Patients With Cancer 712(11)

Robert Finberg

87 Cancer of the Skin 723(10)

Walter J. Urba

Carl V. Washington

Hari Nadiminti

88 Head and Neck Cancer 733(4)

Everett E. Vokes

89 Neoplasms of the Lung 737(17)

Leora Horn

William Pao

David H. Johnson

90 Breast Cancer 754(10)

Marc E. Lippman

91 Gastrointestinal Tract Cancer 764(13)

Robert J. Mayer

92 Tumors of the Liver and Biliary Tree 777(9)

Brian I. Carr

93 Pancreatic Cancer 786(4)

Irene Chong

David Cunningham

94 Bladder and Renal Cell Carcinomas 790(6)

Howard I. Scher

Robert J. Motzer

95 Benign and Malignant Diseases of the Prostate 796(10)

Howard I. Scher

96 Testicular Cancer 806(4)

Robert J. Motzer

George J. Bosl

97 Gynecologic Malignancies 810(7)

Michael V. Seiden

98 Soft Tissue and Bone Sarcomas and Bone Metastases 817(4)

Shreyaskumar R. Patel

Robert S. Benjamin

99 Carcinoma of Unknown Primary 821(5)

Gauri R. Varadhachary

James L. Abbruzzese

100 Paraneoplastic Syndromes: Endocrinologic/Hematologic 826(7)

J. Larry Jameson

Dan L. Longo

101 Paraneoplastic Neurologic Syndromes 833(5)

Josep Dalmau

Myrna R. Rosenfeld

e20 Thymoma

Dan L. Longo

102 Late Consequences of Cancer and Its Treatment 838(6)

Carl E. Freter

Dan L. Longo

Section 2 Hematopoietic Disorders

103 Iron Deficiency and Other Hypoproliferative Anemias 844(8)

John W. Adamson

104 Disorders of Hemoglobin 852(10)

Edward J. Benz, Jr.

105 Megaloblastic Anemias 862(10)

A. Victor Hoffbrand

106 Hemolytic Anemias and Anemia Due to Acute Blood Loss 872(15)

Lucio Luzzatto

107 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes 887(11)

Neal S. Young

108 Polycythemia Vera and Other Myeloproliferative Diseases 898(7)

Jerry L. Spivak

109 Acute and Chronic Myeloid Leukemia 905(14)

Meir Wetzler

Guido Marcucci

Clara D. Bloomfield

110 Malignancies of Lymphoid Cells 919(17)

Dan L. Longo

e21 Less Common Hematologic Malignancies

Dan L. Longo

111 Plasma Cell Disorders 936(9)

Nikhil C. Munshi

Dan L. Longo

Kenneth C. Anderson

112 Amyloidosis 945(6)

David C. Seldin

Martha Skinner

113 Transfusion Biology and Therapy 951(7)

Jeffery S. Dzieczkowski

Kenneth C. Anderson

114 Hematopoietic Cell Transplantation 958(7)

Frederick R. Appelbaum

Section 3 Disorders of Hemostasis

115 Disorders of Platelets and Vessel Wall 965(8)

Barbara Konkle

116 Coagulation Disorders 973(10)

Valder R. Arruda

Katherine A. High

117 Arterial and Venous Thrombosis 983(5)

Jane E. Freedman

Joseph Loscalzo

118 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs 988(19)

Jeffrey I. Weitz

PART 8 Infectious Diseases

Section 1 Basic Considerations in Infectious Diseases

119 Introduction to Infectious Diseases: Host---Pathogen Interactions 1007(6)

Lawrence C. Madoff

Dennis L. Kasper

120 Molecular Mechanisms of Microbial Pathogenesis 1013(10)

Gerald B. Pier

121 Approach to the Acutely III Infected Febrile Patient 1023(8)

Tamar F. Barlam

Dennis L. Kasper

122 Immunization Principles and Vaccine Use 1031(11)

Anne Schuchat

Lisa A. Jackson

123 Health Recommendations for International Travel 1042(10)

Jay S. Keystone

Phyllis E. Kozarsky

e22 Laboratory Diagnosis of Infectious Diseases

Alexander J. McAdam

Andrew B. Onderdonk

Section 2 Clinical Syndromes: Community-Acquired Infections

124 Infective Endocarditis 1052(12)

Adolf W. Karchmer

125 Infections of the Skin, Muscles, and Soft Tissues 1064(7)

Dennis L. Stevens

126 Osteomyelitis 1071(6)

Alan D. Tice

127 Intraabdominal Infections and Abscesses 1077(7)

Miriam J. Baron

Dennis L. Kasper

128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning 1084(7)

Regina C. LaRocque

Edward T. Ryan

Stephen B. Calderwood

129 Clostridium difficile Infection, Including Pseudomembranous Colitis 1091(4)

Dale N. Gerding

Stuart Johnson

130 Sexually Transmitted Infections: Overview and Clinical Approach 1095(17)

Jeanne M. Marrazzo

King K. Holmes

e23 Infectious Complications of Burns

Lawrence C. Madoff

Florencia Pereyra

e24 Infectious Complications of Bites

Lawrence C. Madoff

Florencia Pereyra

Section 3 Clinical Syndromes: Health Care---Associated Infections

131 Health Care---Associated Infections 1112(8)

Robert A. Weinstein

132 Infections in Transplant Recipients 1120(13)

Robert Finberg

Joyce Fingeroth

Section 4 Approach to Therapy for Bacterial Diseases

133 Treatment and Prophylaxis of Bacterial Infections 1133(18)

Gordon L. Archer

Ronald E. Polk

Section 5 Diseases Caused by Gram-Positive Bacteria

134 Pneumococcal Infections 1151(9)

David Goldblatt

Katherine L. O'Brien

135 Staphylococcal Infections 1160(11)

Franklin D. Lowy

136 Streptococcal Infections 1171(9)

Michael R. Wessels

137 Enterococcal Infections 1180(8)

Cesar A. Arias

Barbara E. Murray

138 Diphtheria and Other Infections Caused by Corynebacteria and Related Species 1188(6)

William R. Bishai

John R. Murphy

139 Listeria monocytogenes Infections 1194(3)

Elizabeth L. Hohmann

Daniel A. Portnoy

140 Tetanus 1197(3)

C. Louise Thwaites

Lam Minh Yen

141 Botulism 1200(4)

Jeremy Sobel

Susan Maslanka

142 Gas Gangrene and Other Clostridial Infections 1204(7)

Amy E. Bryant

Dennis L. Stevens

Section 6 Diseases Caused by Gram-Negative Bacteria

143 Meningococcal Infections 1211(9)

Andrew J. Pollard

144 Gonococcal Infections 1220(8)

Sanjay Ram

Peter A. Rice

145 Haemophilus and Moraxella Infections 1228(5)

Timothy F. Murphy

146 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria 1233(3)

Tamar F. Barlam

Dennis L. Kasper

147 Legionella Infections 1236(5)

Miguel Sabria

Victor L. Yu

148 Pertussis and Other Bordetella Infections 1241(5)

Scott A. Halperin

149 Diseases Caused by Gram-Negative Enteric Bacilli 1246(12)

Thomas A. Russo

James R. Johnson

150 Acinetobacter Infections 1258(3)

David L. Paterson

Anton Y. Peleg

151 Helicobacter pylori Infections 1261(5)

John C. Atherton

Martin J. Blaser

152 Infections Due to Pseudomonas Species and Related Organisms 1266(8)

Reuben Ramphal

153 Salmonellosis 1274(7)

David A. Pegues

Samuel I. Miller

154 Shigellosis 1281(5)

Philippe Sansonetti

Jean Bergounioux

155 Infections Due to Campylobacter and Related Organisms 1286(3)

Martin J. Blaser

156 Cholera and Other Vibrioses 1289(7)

Matthew K. Waldor

Edward T. Ryan

157 Brucellosis 1296(5)

Michael J. Corbel

Nicholas J. Beeching

158 Tularemia 1301(4)

Richard F. Jacobs

Gordon E. Schutze

159 Plague and Other Yersinia Infections 1305(9)

Michael B. Prentice

160 Bartonella Infections, Including Cat-Scratch Disease 1314(6)

Michael Giladi

Moshe Ephros

161 Donovanosis 1320(2)

Nigel O'Farrell

Section 7 Miscellaneous Bacterial Infections

162 Nocardiosis 1322(4)

Gregory A. Filice

163 Actinomycosis 1326(5)

Thomas A. Russo

164 Infections Due to Mixed Anaerobic Organisms 1331(9)

Dennis L. Kasper

Ronit Cohen-Poradosu

Section 8 Mycobacterial Diseases

165 Tuberculosis 1340(19)

Mario C. Raviglione

Richard J. O'Brien

166 Leprosy 1359(8)

Robert H. Gelber

167 Nontuberculous Mycobacterial Infections 1367(4)

Steven M. Holland

168 Antimycobacterial Agents 1371(9)

Max R. O'Donnell

Jussi J. Saukkonen

Section 9 Spirochetal Diseases

169 Syphilis 1380(9)

Sheila A. Lukehart

170 Endemic Treponematoses 1389(3)

Sheila A. Lukehart

171 Leptospirosis 1392(5)

Joseph M. Vinetz

172 Relapsing Fever 1397(4)

Mark S. Dworkin

173 Lyme Borreliosis 1401(6)

Allen C. Steere

Section 10 Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae

174 Rickettsial Diseases 1407(10)

David H. Walker

J. Stephen Dumler

Thomas Marrie

175 Infections Due to Mycoplasmas 1417(4)

R. Doug Hardy

176 Chlamydial Infections 1421(11)

Charlotte A. Gaydos

Thomas C. Quinn

Section 11 Viral Diseases: General Considerations

177 Medical Virology 1432(10)

Fred Wang

Elliott Kieff

178 Antiviral Chemotherapy, Excluding Antiretroviral Drugs 1442(11)

Lindsey R. Baden

Raphael Dolin

Section 12 Infections Due to DNA Viruses

179 Herpes Simplex Virus Infections 1453(9)

Lawrence Corey

180 Varicella-Zoster Virus Infections 1462(5)

Richard J. Whitley

181 Epstein-Barr Virus Infections, Including Infectious Mononucleosis 1467(4)

Jeffrey I. Cohen

182 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 1471(5)

Martin S. Hirsch

183 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections 1476(2)

Fred Wang

184 Parvovirus Infections 1478(3)

Kevin E. Brown

185 Human Papillomavirus Infections 1481(4)

Richard C. Reichman

Section 13 Infections Due to DNA and RNA Respiratory Viruses

186 Common Viral Respiratory Infections 1485(8)

Raphael Dolin

187 Influenza 1493(7)

Raphael Dolin

Section 14 Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

188 The Human Retroviruses 1500(6)

Dan L. Longo

Anthony S. Fauci

189 Human Immunodeficiency Virus Disease: AIDS and Related Disorders 1506(82)

Anthony S. Fauci

H. Clifford Lane

Section 15 Infections Due to RNA Viruses

190 Viral Gastroenteritis 1588(5)

Umesh D. Parashar

Roger I. Glass

191 Enteroviruses and Reoviruses 1593(7)

Jeffrey I. Cohen

192 Measles (Rubeola) 1600(5)

William J. Moss

193 Rubella (German Measles) 1605(3)

Laura A. Zimmerman

Susan E. Reef

194 Mumps 1608(3)

Steven Rubin

Kathryn M. Carbone

195 Rabies and Other Rhabdovirus Infections 1611(6)

Alan C. Jackson

196 Infections Caused by Arthropod- and Rodent-Borne Viruses 1617(16)

Clarence J. Peters

197 Ebola and Marburg Viruses 1633(6)

Clarence J. Peters

Section 16 Fungal Infections

198 Diagnosis and Treatment of Fungal Infections 1639(3)

John E. Edwards, Jr.

199 Histoplasmosis 1642(3)

Chadi A. Hage

L. Joseph Wheat

200 Coccidioidomycosis 1645(3)

Neil M. Ampel

201 Blastomycosis 1648(2)

Stanley W. Chapman

Donna C. Sullivan

202 Cryptococcosis 1650(3)

Arturo Casadevall

203 Candidiasis 1653(4)

John E. Edwards, Jr.

204 Aspergillosis 1657(6)

David W. Denning

205 Mucormycosis 1663(4)

Brad Spellberg

Ashraf S. Ibrahim

206 Superficial Mycoses and Less Common Systemic Mycoses 1667(6)

Carol A. Kauffman

207 Pneumocystis Infections 1673(4)

A. George Smulian

Peter D. Walzer

Section 17 Protozoal and Helminthic Infections: General Considerations

e25 Laboratory Diagnosis of Parasitic Infections

Sharon L. Reed

Charles E. Davis

208 Agents Used to Treat Parasitic Infections 1677(6)

Thomas A. Moore

e26 Pharmacology of Agents Used to Treat Parasitic Infections

Thomas A. Moore

Section 18 Protozoal Infections

209 Amebiasis and Infection With Free-Living Amebas 1683(5)

Samuel L. Stanley, Jr.

210 Malaria 1688(18)

Nicholas J. White

Joel G. Breman

211 Babesiosis 1706(3)

Edouard Vannier

Jeffrey A. Gelfand

e27 Atlas of Blood Smears of Malaria and Babesiosis

Nicholas J. White

Joel G. Breman

212 Leishmaniasis 1709(7)

Shyam Sundar

213 Chagas' Disease and Trypanosomiasis 1716(6)

Louis V. Kirchhoff

Anis Rassi, Jr.

214 Toxoplasma Infections 1722(7)

Kami Kim

Lloyd H. Kasper

215 Protozoal Intestinal Infections and Trichomoniasis 1729(6)

Peter F. Weller

Section 19 Helminthic Infections

216 Trichinellosis and Other Tissue Nematode Infections 1735(4)

Peter F. Weller

217 Intestinal Nematode Infections 1739(6)

Peter F. Weller

Thomas B. Nutman

218 Filarial and Related Infections 1745(7)

Thomas B. Nutman

Peter F. Weller

219 Schistosomiasis and Other Trematode Infections 1752(7)

Adel A. F. Mahmoud

220 Cestode Infections 1759(9)

A. Clinton White, Jr.

Peter F. Weller

PART 9 Terrorism and Clinical Medicine

221 Microbial Bioterrorism 1768(11)

H. Clifford Lane

Anthony S. Fauci

222 Chemical Terrorism 1779(9)

Charles G. Hurst

Jonathan Newmark

James A. Romano, Jr.

223 Radiation Terrorism 1788(10)

Zelig A. Tochner

Eli Glatstein

PART 10 Disorders of the Cardiovascular System

Section 1 Introduction to Cardiovascular Disorders

224 Basic Biology of the Cardiovascular System 1798(13)

Joseph Loscalzo

Peter Libby

Jonathan Epstein

225 Epidemiology of Cardiovascular Disease 1811(6)

Thomas A. Gaziano

J. Michael Gaziano

226 Approach to the Patient With Possible Cardiovascular Disease 1817(4)

Joseph Loscalzo

Section 2 Diagnosis of Cardiovascular Disorders

227 Physical Examination of the Cardiovascular System 1821(10)

Patrick T. O'Gara

Joseph Loscalzo

228 Electrocardiography 1831(9)

Ary L. Goldberger

e28 Atlas of Electrocardiography

Ary L. Goldberger

229 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging 1840(13)

Rick A. Nishimura

Pamithaya Chareonthaitawee

Matthew Martinez

e29 Atlas of Noninvasive Cardiac Imaging

Rick A. Nishimura

Panithya Chareonthaitawee

Matthew Martinez

230 Diagnostic Cardiac Catheterization and Coronary Angiography 1853(7)

Jane A. Leopold

David P. Faxon

Section 3 Disorders of Rhythm

231 Principles of Electrophysiology 1860(7)

David D. Spragg

Gordon F. Tomaselli

232 The Bradyarrhythmias 1867(11)

David D. Spragg

Gordon F. Tomaselli

233 The Tachyarrhythmias 1878(23)

Francis Marchlinski

e30 Atlas of Cardiac Arrhythmias

Ary L. Goldberger

Section 4 Disorders of the Heart

234 Heart Failure and Cor Pulmonale 1901(15)

Douglas L. Mann

Murali Chakinala

235 Cardiac Transplantation and Prolonged Assisted Circulation 1916(4)

Sharon A. Hunt

Hari R. Mallidi

236 Congenital Heart Disease in the Adult 1920(9)

John S. Child

Jamil Aboulhosn

237 Valvular Heart Disease 1929(22)

Patrick T. O'Gara

Joseph Loscalzo

238 Cardiomyopathy and Myocarditis 1951(20)

Lynne Warner Stevenson

Joseph Loscalzo

239 Pericardial Disease 1971(8)

Eugene Braunwald

240 Tumors and Trauma of the Heart 1979(4)

Eric H. Awtry

Wilson S. Colucci

e31 Cardiac Manifestations of Systemic Disease

Eric H. Awtry

Wilson S. Colucci

Section 5 Vascular Disease

241 The Pathogenesis, Prevention, and Treatment of Atherosclerosis 1983(9)

Peter Libby

e32 Atlas of Atherosclerosis

Peter Libby

242 The Metabolic Syndrome 1992(6)

Robert H. Eckel

243 Ischemic Heart Disease 1998(17)

Elliott M. Antman

Andrew P. Selwyn

Joseph Loscalzo

244 Unstable Angina and Non-ST-Segment Elevation Myocardial Infarction 2015(6)

Christopher P. Cannon

Eugene Braunwald

245 ST-Segment Elevation Myocardial Infarction 2021(14)

Elliott M. Antman

Joseph Loscalzo

246 Percutaneous Coronary Interventions and Other Interventional Procedures 2035(7)

David P. Faxon

Deepak L. Bhatt

e33 Atlas of Percutaneous Revascularization

Jane A. Leopold

Deepak L. Bhatt

David P. Faxon

247 Hypertensive Vascular Disease 2042(18)

Theodore A. Kotchen

248 Diseases of the Aorta 2060(6)

Mark A. Creager

Joseph Loscalzo

249 Vascular Diseases of the Extremities 2066(10)

Mark A. Creager

Joseph Loscalzo

250 Pulmonary Hypertension 2076(8)

Stuart Rich

PART 11 Disorders of the Respiratory System

Section 1 Diagnosis of Respiratory Disorders

251 Approach to the Patient With Disease of the Respiratory System 2084(3)

Patricia Kritek

Augustine M.K. Choi

252 Disturbances of Respiratory Function 2087(7)

Edward T. Naureckas

Julian Solway

253 Diagnostic Procedures in Respiratory Disease 2094(8)

Anne L. Fuhlbrigge

Augustine M. K. Choi

e34 Atlas of Chest Imaging

Patricia Kritek

John J. Reilly, Jr.

Section 2 Diseases of the Respiratory System

254 Asthma 2102(14)

Peter J. Barnes

255 Hypersensitivity Pneumonitis and Pulmonary Infiltrates With Eosinophilia 2116(5)

Alicia K. Gerke

Gary W. Hunninghake

256 Occupational and Environmental Lung Disease 2121(9)

John R. Balmes

Frank E. Speizer

257 Pneumonia 2130(12)

Lionel A. Mandell

Richard Wunderink

258 Bronchiectasis and Lung Abscess 2142(5)

Rebecca M. Baron

John G. Bartlett

259 Cystic Fibrosis 2147(4)

Richard C. Boucher

260 Chronic Obstructive Pulmonary Disease 2151(9)

John J. Reilly, Jr.

Edwin K. Silverman

Steven D. Shapiro

261 Interstitial Lung Diseases 2160(10)

Talmadge E. King, Jr.

262 Deep Venous Thrombosis and Pulmonary Thromboembolism 2170(8)

Samuel Z. Goldhaber

263 Disorders of the Pleura and Mediastinum 2178(4)

Richard W. Light

264 Disorders of Ventilation 2182(4)

John F. McConville

Julian Solway

265 Sleep Apnea 2186(3)

Neil J. Douglas

266 Lung Transplantation 2189(7)

Elbert P. Trulock

PART 12 Critical Care Medicine

Section 1 Respiratory Critical Care

267 Approach to the Patient With Critical Illness 2196(9)

John P. Kress

Jesse B. Hall

268 Acute Respiratory Distress Syndrome 2205(5)

Bruce D. Levy

Augustine M. K. Choi

269 Mechanical Ventilatory Support 2210(5)

Bartolome R. Celli

Section 2 Shock and Cardiac Arrest

270 Approach to the Patient With Shock 2215(8)

Ronald V. Maier

271 Severe Sepsis and Septic Shock 2223(9)

Robert S. Munford

272 Cardiogenic Shock and Pulmonary Edema 2232(6)

Judith S. Hochman

David H. Ingbar

273 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death 2238(9)

Robert J. Myerburg

Agustin Castellanos

Section 3 Neurologic Critical Care

274 Coma 2247(7)

Allan H. Ropper

275 Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage 2254(12)

J. Claude Hemphill, III

Wade S. Smith

Daryl R. Gress

Section 4 Oncologic Emergencies

276 Oncologic Emergencies 2266(14)

Rasim Gucalp

Janice Dutcher

PART 13 Disorders of the Kidney and Urinary Tract

277 Cellular and Molecular Biology of the Kidney 2280(9)

Alfred L. George, Jr.

Eric G. Neilson

278 Adaption of the Kidney to Renal Injury 2289(4)

Raymond C. Harris

Eric G. Neilson

279 Acute Kidney Injury 2293(15)

Sushrut S. Waikar

Joseph V. Bonventre

280 Chronic Kidney Disease 2308(14)

Joanne M. Bargman

Karl Skorecki

281 Dialysis in the Treatment of Renal Failure 2322(5)

Kathleen D. Liu

Glenn M. Chertow

282 Transplantation in the Treatment of Renal Failure 2327(7)

Anil Chandraker

Edgar L. Milford

Mohamed H. Sayegh

283 Glomerular Diseases 2334(21)

Julia B. Lewis

Eric G. Neilson

284 Polycystic Kidney Disease and Other Inherited Tubular Disorders 2355(12)

David J. Salant

Craig E. Gordon

285 Tubulointerstitial Diseases of the Kidney 2367(8)

Laurence H. Beck

David J. Salant

286 Vascular Injury to the Kidney 2375(7)

Stephen C. Textor

Nelson Leung

287 Nephrolithiasis 2382(5)

John R. Asplin

Fredric L. Coe

Murray J. Favus

288 Urinary Tract Infections, Pyelonephritis, and Prostatitis 2387(9)

Barbara W. Trautner

Kalpana Gupta

e35 Interstitial Cystitis/Painful Bladder Syndrome

John W. Warren

289 Urinary Tract Obstruction 2396(6)

Julian L. Seifter

PART 14 Disorders of the Gastrointestinal System

Section 1 Disorders of the Alimentary Tract

290 Approach to the Patient With Gastrointestinal Disease 2402(7)

William L. Hasler

Chung Owyang

291 Gastrointestinal Endoscopy 2409(18)

Louis Michel Wong Kee Song

Mark Topazian

e36 Video Atlas of Gastrointestinal Endoscopy

Louis Michel Wong Kee Song

Mark Topazian

292 Diseases of the Esophagus 2427(11)

Peter J. Kahrilas

Ikuo Hirano

293 Peptic Ulcer Disease and Related Disorders 2438(22)

John Del Valle

294 Disorders of Absorption 2460(17)

Henry J. Binder

e37 The Schilling Test

Henry J. Binder

295 Inflammatory Bowel Disease 2477(19)

Sonia Friedman

Richard S. Blumberg

296 Irritable Bowel Syndrome 2496(6)

Chung Owyang

297 Diverticular Disease and Common Anorectal Disorders 2502(8)

Susan L. Gearhart

298 Mesenteric Vascular Insufficiency 2510(3)

Susan L. Gearhart

299 Acute Intestinal Obstruction 2513(3)

William Silen

300 Acute Appendicitis and Peritonitis 2516(4)

William Silen

Section 2 Liver and Biliary Tract Disease

301 Approach to the Patient With Liver Disease 2520(7)

Marc Ghany

Jay H. Hoofnagle

302 Evaluation of Liver Function 2527(4)

Daniel S. Pratt

Marshall M. Kaplan

303 The Hyperbilirubinemias 2531(6)

Allan W. Wolkoff

304 Acute Viral Hepatitis 2537(21)

Jules L. Dienstag

305 Toxic and Drug-Induced Hepatitis 2558(9)

Jules L. Dienstag

306 Chronic Hepatitis 2567(22)

Jules L. Dienstag

307 Alcoholic Liver Disease 2589(3)

Mark E. Mailliard

Michael F. Sorrell

308 Cirrhosis and Its Complications 2592(11)

Bruce R. Bacon

e38 Atlas of Liver Biopsies

Jules L. Dienstag

Atul K. Bhan

309 Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver 2603(3)

Bruce R. Bacon

310 Liver Transplantation 2606(9)

Jules L. Dienstag

Raymond T. Chung

311 Diseases of the Gallbladder and Bile Ducts 2615(14)

Norton J. Greenberger

Gustav Paumgartner

Section 3 Disorders of the Pancreas

312 Approach to the Patient With Pancreatic Disease 2629(5)

Norton J. Greenberger

Darwin L. Conwell

Peter A. Banks

313 Acute and Chronic Pancreatitis 2634(16)

Norton J. Greenberger

Darwin L. Conwell

Bechien U. Wu

Peter A. Banks

PART 15 Disorders of the Joints and Adjacent Tissues

Section 1 The Immune System in Health and Disease

314 Introduction to the Immune System 2650(35)

Barton F. Haynes

Kelly A. Soderberg

Anthony S. Fauci

315 The Major Histocompatibility Complex 2685(10)

Gerald T. Nepom

316 Primary Immune Deficiency Diseases 2695(12)

Alain Fischer

e39 Primary Immunodeficiencies Associated With (or Secondary to) Other Diseases

Alain Fischer

Section 2 Disorders of Immune-Mediated Injury

317 Allergies, Anaphylaxis, and Systemic Mastocytosis 2707(12)

K. Frank Austen

318 Autoimmunity and Autoimmune Diseases 2719(5)

Betty Diamond

Peter E. Lipsky

319 Systemic Lupus Erythematosus 2724(12)

Bevra Hannahs Hahn

320 Antiphospholipid Antibody Syndrome 2736(2)

Haralampos M. Moutsopoulos

Panayiotis G. Vlachoyiannopoulos

321 Rheumatoid Arthritis 2738(14)

Ankoor Shah

E. William St. Clair

322 Acute Rheumatic Fever 2752(5)

Jonathan R. Carapetis

323 Systemic Sclerosis (Scleroderma) and Related Disorders 2757(13)

John Varga

324 Sjogren's Syndrome 2770(4)

Haralampos M. Moutsopoulos

Athanasios G. Tzioufas

325 The Spondyloarthritides 2774(11)

Joel D. Taurog

326 The Vasculitis Syndromes 2785(16)

Carol A. Langford

Anthony S. Fauci

e40 Atlas of the Vasculitic Syndromes

Carol A. Langford

Anthony S. Fauci

327 Behcet's Syndrome 2801(1)

Haralampos M. Moutsopoulos

328 Relapsing Polychondritis 2802(3)

Carol A. Langford

329 Sarcoidosis 2805(9)

Robert P. Baughman

Elyse E. Lower

330 Familial Mediterranean Fever and Other Hereditary Recurrent Fevers 2814(4)

Daniel L. Kastner

Section 3 Disorders of the Joints and Adjacent Tissues

331 Approach to Articular and Musculoskeletal Disorders 2818(10)

John J. Cush

Peter E. Lipsky

332 Osteoarthritis 2828(9)

David T. Felson

333 Gout and Other Crystal-Associated Arthropathies 2837(5)

H. Ralph Schumacher

Lan X. Chen

334 Infectious Arthritis 2842(7)

Lawrence C. Madoff

335 Fibromyalgia 2849(3)

Leslie J. Crofford

336 Arthritis Associated With Systemic Disease, and Other Arthritides 2852(8)

Carol A. Langford

Brian F. Mandell

337 Periarticular Disorders of the Extremities 2860(6)

Carol A. Langford

Bruce C. Gilliland

PART 16 Endocrinology and Metabolism

Section 1 Endocrinology

338 Principles of Endocrinology 2866(10)

J. Larry Jameson

339 Disorders of the Anterior Pituitary and Hypothalamus 2876(26)

Shlomo Melmed

J. Larry Jameson

340 Disorders of the Neurohypophysis 2902(9)

Gary L. Robertson

341 Disorders of the Thyroid Gland 2911(29)

J. Larry Jameson

Anthony P. Weetman

342 Disorders of the Adrenal Cortex 2940(22)

Wiebke Arlt

343 Pheochromocytoma 2962(6)

Hartmut P.H. Neumann

344 Diabetes Mellitus 2968(35)

Alvin C. Powers

345 Hypoglycemia 3003(7)

Philip E. Cryer

Stephen N. Davis

346 Disorders of the Testes and Male Reproductive System 3010(18)

Shalender Bhasin

J. Larry Jameson

347 The Female Reproductive System, Infertility, and Contraception 3028(12)

Janet E. Hall

348 The Menopause Transition and Postmenopausal Hormone Therapy 3040(6)

JoAnn E. Manson

Shari S. Bassuk

349 Disorders of Sex Development 3046(10)

John C. Achermann

J. Larry Jameson

350 Endocrine Tumors of the Gastrointestinal Tract and Pancreas 3056(16)

Robert T. Jensen

351 Disorders Affecting Multiple Endocrine Systems 3072(10)

Camilo Jimenez Vasquez

Robert F. Gagel

Section 2 Disorders of Bone and Mineral Metabolism

352 Bone and Mineral Metabolism in Health and Disease 3082(14)

F. Richard Bringhurst

Marie B. Demay

Stephen M. Krane

Henry M. Kronenberg

353 Disorders of the Parathyroid Gland and Calcium Homeostasis 3096(24)

John T. Potts, Jr.

Harald Juppner

354 Osteoporosis 3120(16)

Robert Lindsay

Felicia Cosman

355 Paget's Disease and Other Dysplasias of Bone 3136(9)

Murray J. Favus

Tamara J. Vokes

Section 3 Disorders of Intermediary Metabolism

356 Disorders of Lipoprotein Metabolism 3145(17)

Daniel J. Rader

Helen H. Hobbs

357 Hemochromatosis 3162(5)

Lawrie W. Powell

358 The Porphyrias 3167(14)

Robert J. Desnick

Manisha Balwani

359 Disorders of Purine and Pyrimidine Metabolism 3181(7)

Christopher M. Burns

Robert L. Wortmann

360 Wilson's Disease 3188(3)

George J. Brewer

361 Lysosomal Storage Diseases 3191(7)

Robert Hopkin

Gregory A. Grabowski

362 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism 3198(6)

Priya S. Kishnani

Yuan-Tsong Chen

363 Heritable Disorders of Connective Tissue 3204(10)

Darwin J. Prockop

John F. Bateman

364 Inherited Disorders of Amino Acid Metabolism in Adults 3214(6)

Nicola Longo

365 Inherited Defects of Membrane Transport 3220(4)

Nicola Longo

e41 Atlas of Clinical Manifestations of Metabolic Diseases

J. Larry Jameson

PART 17 Neurologic Disorders

Section 1 Diagnosis of Neurologic Disorders

366 Biology of Neurologic Diseases 3224(9)

Stephen L. Hauser

M. Flint Beal

367 Approach to the Patient With Neurologic Disease 3233(7)

Daniel H. Lowenstein

Joseph B. Martin

Stephen L. Hauser

e42 The Neurologic Screening Exam

Daniel H. Lowenstein

e43 Video Atlas of the Detailed Neurologic Examination

Martin A. Samuels

368 Neuroimaging in Neurologic Disorders 3240(11)

William P. Dillon

e44 Atlas of Neuroimaging

Andre Furtado

William P. Dillon

e45 Electrodiagnostic Studies of Nervous System Disorders: EEG, Evoked Potentials, and EMG

Michael J. Aminoff

e46 Technique of Lumbar Puncture

Elizabeth Robbins

Stephen L. Hauser

Section 2 Diseases of the Central Nervous System

369 Seizures and Epilepsy 3251(19)

Daniel H. Lowenstein

370 Cerebrovascular Diseases 3270(30)

Wade S. Smith

Joey D. English

S. Claiborne Johnston

371 Dementia 3300(17)

William W. Seeley

Bruce L. Miller

372 Parkinson's Disease and Other Movement Disorders 3317(18)

C. Warren Olanow

Anthony H.V. Schapira

373 Ataxic Disorders 3335(10)

Roger N. Rosenberg

374 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases 3345(6)

Robert H. Brown, Jr.

375 Disorders of the Autonomic Nervous System 3351(9)

Phillip A. Low

John W. Engstrom

376 Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders 3360(6)

M. Flint Beal

Stephen L. Hauser

377 Diseases of the Spinal Cord 3366(11)

Stephen L. Hauser

Allan H. Ropper

378 Concussion and Other Head Injuries 3377(5)

Allan H. Ropper

379 Primary and Metastatic Tumors of the Nervous System 3382(13)

Lisa M. DeAngelis

Patrick Y. Wen

380 Multiple Sclerosis and Other Demyelinating Diseases 3395(15)

Stephen L. Hauser

Douglas S. Goodin

381 Meningitis, Encephalitis, Brain Abscess, and Empyema 3410(25)

Karen L. Roos

Kenneth L. Tyler

382 Chronic and Recurrent Meningitis 3435(6)

Walter J. Koroshetz

Morton N. Swartz

383 Prion Diseases 3441(7)

Stanley B. Prusiner

Bruce L. Miller

Section 3 Nerve and Muscle Disorders

384 Peripheral Neuropathy 3448(25)

Anthony A. Amato

Richard J. Barohn

385 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies 3473(7)

Stephen L. Hauser

Anthony A. Amato

386 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction 3480(7)

Daniel B. Drachman

387 Muscular Dystrophies and Other Muscle Diseases 3487(22)

Anthony A. Amato

Robert H. Brown, Jr.

388 Polymyositis, Dermatomyositis, and Inclusion Body Myositis 3509(10)

Marinos C. Dalakas

e47 Special Issues in Inpatient Neurologic Consultation

S. Andrew Josephson

Martin A. Samuels

Section 4 Chronic Fatigue Syndrome

389 Chronic Fatigue Syndrome 3519(3)

Gijs Bleijenberg

Jos W.M. van der Meer

Section 5 Psychiatric Disorders

390 Biology of Psychiatric Disorders 3522(7)

Robert O. Messing

John H. Rubenstein

Eric J. Nestler

391 Mental Disorders 3529(17)

Victor I. Reus

Section 6 Alcoholism and Drug Dependency

392 Alcohol and Alcoholism 3546(6)

Marc A. Schuckit

393 Opioid Drug Abuse and Dependence 3552(4)

Thomas R. Kosten

394 Cocaine and Other Commonly Abused Drugs 3556(4)

Nancy K. Mello

Jack H. Mendelson

395 Nicotine Addiction 3560(6)

David M. Burns

e48 Neuropsychiatric Illnesses in War Veterans

Charles W. Hoge

PART 18 Poisoning, Drug Overdose, and Envenomation

e49 Heavy Metal Poisoning

Howard Hu

e50 Poisoning and Drug Overdosage

Mark B. Mycyk

396 Disorders Caused by Venomous Snakebites and Marine Animal Exposures 3566(10)

Paul S. Auerbach

Robert L. Norris

397 Ectoparasite Infestations and Arthropod Bites and Stings 3576(9)

Richard J. Pollack

PART 19 High-Altitude and Decompression Sickness

e51 Altitude Illness

Buddha Basnyat

Geoffrey Tabin

e52 Hyperbaric and Diving Medicine

Michael H. Bennett

Simon J. Mitchell

Appendix: Laboratory Values of Clinical Importance 3585(26)

Alexander Kratz

Michael A. Pesce

Robert C. Basner

Andrew J. Einstein

e53 The Clinical Laboratory in Modern Health Care

Anthony A. Killeen

e54 Clinical Procedure Tutorial: Central Venous Catheter Placement

Maria A. Yialamas

William Corcoran

Gyorgy Frendl

e55 Clinical Procedure Tutorial: Thoracentesis

Charles A. Morris

Andrea Wolf

e56 Clinical Procedure Tutorial: Abdominal Paracentesis

Maria A. Yialamas

Anna Rutherford

Lindsay King

e57 Clinical Procedure Tutorial: Endotracheal Intubation

Charles A. Morris

Emily Nelson Maher
Index 3611