简介
Summary:
Publisher Summary 1
In this collection of 22 papers, contributors describe their work in angiogenic diseases, endogenous promoters and inhibitors of angiogenesis, and promising therapeutics and delivery for angiogenic eye diseases. Diseases and conditions covered include endogenous angiogenic inhibitors in diabetic retinopathy, corneal angiogenesis, polypoidal choroidal vasculopathy, myopic choroidal neovascularization, Eale's Disease, ocular tumorigenesis and the genetics of ocular vascular disease. Topics on endogenous promoters and inhibitors include considerations of growth factors in retinal diseases and the role of fibroblast growth factors, control and cell survival in the eye by PEDF, integrins and inhibition by matrix proteases and tissue inhibitors of metalloproteinases. Therapeutics and deliver include anti-VEGF therapies, anecortave acetate, gene therapy for retinopathies, noninvasive DNA delivery into the eye and novel drug delivery systems. Annotation 漏2006 Book News, Inc., Portland, OR (booknews.com)
Publisher Summary 2
Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.
目录
Preface p. v
Contributors p. xi
Companion CD p. xv
I Angiogenic Diseases
1 Age-Related Macular Degeneration Curtis L. Hagedorn and Ron A. Adelman p. 3
2 Endogenous Angiogenic Inhibitors in Diabetic Retinopathy Jian-Xing Ma and Sarah X. Zhang p. 23
3 Corneal Angiogenesis Trevor R. Carmichael p. 45
4 Polypoidal Choroidal Vasculopathy Nahoko Ogata and Kanji Takahashi p. 73
5 Myopic Choroidal Neovascularization Kyoko Ohno-Matsui and Takashi Tokoro p. 85
6 Mechanisms of the Formation and Stability of Retinal Blood Vessels Jonathan Stone and Trent Sandercoe and Jan Provis p. 101
7 Neovascular Glaucoma James C. Tsai and M. Bruce Shields p. 127
8 Eales' Disease Jyotirmay Biswas p. 149
9 Angiogenesis and Ocular Tumorigenesis Nader Sheibani and Daniel M. Albert p. 161
10 Genetics of Ocular Vascular Disease Jacquie Greenberg and Ari Ziskind and Stephen P. Daiger p. 173
II Endogenous Promoters And Inhibitors Of Angiogenesis
11 Vascular Endothelial Growth Factor and Retinal Diseases Sam Dahr and Karl G. Csaky p. 191
12 The Role of Fibroblast Growth Factors in Ocular Angiogenesis Andreas Bikfalvi and Sophie Javerzat p. 205
13 Control of Neovascularization and Cell Survival in the Eye by PEDF Joyce Tombran-Tink and Colin J. Barnstable
14 Thrombospondin: Guarding the Clear View Olga V. Volpert p. 233Arin Auro
15 Regulation of Ocular Angiogenesis by Matrix Proteases and Tissue Inhibitors of Metalloproteinases Bela Anand-Apte p. 257
16 Integrins in Ocular Angiogenesis Matthew R. Ritter and Martin Friedlander p. 279
17 Ocular Inflammation and Neovascularization Chi-Chao Chan and Robert B. Nussenblatt p. 291
III Therapeutics And Delivery For Angiogenic Eye Diseases
18 Anti-VEGF Therapies for Diseases of the Retina and Choroid Ming Lu|vDonald J. D'Amico p. 309
19 Anecortave Acetate: A Novel Ocular Angiostatic Agent Stella M. Robertson and Alberta A. Davis and David C. Dahlin and Abbot F. Clark p. 341
20 Gene Therapy for Neovascular Retinopathies Brian J. Raisler and Kenneth I. Berns and William W. Hauswirth p. 355
21 Noninvasive Delivery of DNA Into the Eye John M. Nickerson and R. Keith Shuler, Jr. and John B. Davies and Phyllis K. Dioguardi and Steven M. Wolchok and Vincent T. Ciavatta and Jeffrey H. Boatright and Henry F. Edelhauser p. 373
22 Novel Drug Delivery Systems for Posterior Segment Ocular Disease Heather Sheardown and W. Mark Saltzman p. 393
Index p. 409
Contributors p. xi
Companion CD p. xv
I Angiogenic Diseases
1 Age-Related Macular Degeneration Curtis L. Hagedorn and Ron A. Adelman p. 3
2 Endogenous Angiogenic Inhibitors in Diabetic Retinopathy Jian-Xing Ma and Sarah X. Zhang p. 23
3 Corneal Angiogenesis Trevor R. Carmichael p. 45
4 Polypoidal Choroidal Vasculopathy Nahoko Ogata and Kanji Takahashi p. 73
5 Myopic Choroidal Neovascularization Kyoko Ohno-Matsui and Takashi Tokoro p. 85
6 Mechanisms of the Formation and Stability of Retinal Blood Vessels Jonathan Stone and Trent Sandercoe and Jan Provis p. 101
7 Neovascular Glaucoma James C. Tsai and M. Bruce Shields p. 127
8 Eales' Disease Jyotirmay Biswas p. 149
9 Angiogenesis and Ocular Tumorigenesis Nader Sheibani and Daniel M. Albert p. 161
10 Genetics of Ocular Vascular Disease Jacquie Greenberg and Ari Ziskind and Stephen P. Daiger p. 173
II Endogenous Promoters And Inhibitors Of Angiogenesis
11 Vascular Endothelial Growth Factor and Retinal Diseases Sam Dahr and Karl G. Csaky p. 191
12 The Role of Fibroblast Growth Factors in Ocular Angiogenesis Andreas Bikfalvi and Sophie Javerzat p. 205
13 Control of Neovascularization and Cell Survival in the Eye by PEDF Joyce Tombran-Tink and Colin J. Barnstable
14 Thrombospondin: Guarding the Clear View Olga V. Volpert p. 233Arin Auro
15 Regulation of Ocular Angiogenesis by Matrix Proteases and Tissue Inhibitors of Metalloproteinases Bela Anand-Apte p. 257
16 Integrins in Ocular Angiogenesis Matthew R. Ritter and Martin Friedlander p. 279
17 Ocular Inflammation and Neovascularization Chi-Chao Chan and Robert B. Nussenblatt p. 291
III Therapeutics And Delivery For Angiogenic Eye Diseases
18 Anti-VEGF Therapies for Diseases of the Retina and Choroid Ming Lu|vDonald J. D'Amico p. 309
19 Anecortave Acetate: A Novel Ocular Angiostatic Agent Stella M. Robertson and Alberta A. Davis and David C. Dahlin and Abbot F. Clark p. 341
20 Gene Therapy for Neovascular Retinopathies Brian J. Raisler and Kenneth I. Berns and William W. Hauswirth p. 355
21 Noninvasive Delivery of DNA Into the Eye John M. Nickerson and R. Keith Shuler, Jr. and John B. Davies and Phyllis K. Dioguardi and Steven M. Wolchok and Vincent T. Ciavatta and Jeffrey H. Boatright and Henry F. Edelhauser p. 373
22 Novel Drug Delivery Systems for Posterior Segment Ocular Disease Heather Sheardown and W. Mark Saltzman p. 393
Index p. 409
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