Table Of Contents:
Foreword ix
Preface xi
Contributors xiii
History of the Meakins-Christie Laboratories xix

SECTION I ANATOMY

Histology and Gross Anatomy of the Respiratory Tract 1(14)

Richard S. Fraser

SECTION II MECHANICS OF BREATHING

Statics of the Respiratory System 15(12)

Edgardo D'Angelo

Joseph Milic-Emili

Statics of the Lung 27(8)

Joseph Milic-Emili

Edgardo D'Angelo

Act of Breathing: Dynamics 35(14)

Peter T. Macklem

Respiratory Mechanics in Infants and Children 49(6)

Peter D. Sly

Felicity S. Flack

Zoltan Hantos

Physics of Expiratory Flow Limitation 55(6)

Jason H.T. Bates

Act of Breathing: The Ventilatory Pump 61(8)

Peter T. Macklem

Pulmonary Statics in Disease 69(8)

Paolo Carbonara

David H. Eidelman

Structure-Function Correlations in Pulmonary Fibrosis 77(8)

Anne Gonzalez

Mara S. Ludwig

Structure-Function Relationships in Chronic Obstructive Pulmonary Disease 85(20)

Manuel G. Cosio

Marina Saetta

Heberto Ghezzo

Simonetta Baraldo

Structure-Function Correlations in Asthma 105(10)

Mara Ludwig

Structure-Function Relationships in Airway Disease: Analysis by Computed Tomographic Imaging 115(8)

Michiaki Mishima

Breathing Strategies in Asthma and Chronic Obstructive Lung Disease 123(10)

James G. Martin

SECTION III VENTILATION, PULMONARY CIRCULATION AND GAS EXCHANGE

Ventilation Distribution 133(10)

Joseph Milic-Emili

Gas Convection and Diffusion 143(12)

Manuel Paiva

Sylvia Verbanck

Lung Vasculature: Functional Inferences from Microstructure 155(10)

Dean E. Schraufnagel

Ventilation-Perfusion Relationships 165(20)

Peter D. Wagner

Ventilation--Perfusion Distributions In Disease 185(18)

Antoni Ferrer

Robert Rodriguez-Roisin

Pulmonary Edema 203(34)

Rene P. Michel

Peter Goldberg

Oxygen Regulation of Vasomotor Tone 237(14)

David Hall

Duncan Stewart

Michael Ward

SECTION IV RESPIRATORY MUSCLES AND CONTROL OF BREATHING

Neural Control of Breathing 251(12)

Immanuela Rave Moss

Actions of the Respiratory Muscles 263(14)

Andre de Troyer

Biology of the Respiratory Muscles 277(12)

Ghislaine Gayan-Ramirez

Marc Decramer

Respiratory Muscle Fatigue 289(20)

Spyros Zakynthinos

Charis Roussos

Ventilatory Muscle Injury 309(10)

Xiangyu Wang

Tian-Xi Jiang

W. Darlene Reid

Jeremy Road

Respiratory Consequences of Neuromuscular Disease 319(12)

Stefan Matecki

Basil J. Petrof

Respiratory Muscles in Sepsis 331(8)

Camille Taille

Sophie Lanone

Jorge Boczkowski

Michel Aubier

Rehabilitation of Skeletal Muscles in Chronic Obstructive Pulmonary Disease 339(10)

Thierry Troosters

Rik Gosselink

Marc Decramer

SECTION V AIRWAYS AND LUNG DEFENSE

Genetics of Respiratory Disease 349(14)

Scott J. Tebbutt

Andrew J. Sandford

Peter D. Pare

Neurohumoral Control of the Airways 363(8)

Marie-Claire Michoud

Mechanics of Airway Narrowing 371(10)

Peter D. Pare

Peter T. Macklem

Chun Y. Seow

Brent E. McParland

Airway Smooth Muscle: The Contractile Phenotype 381(8)

Elizabeth D. Fixman

Barbara Tolloczko

Anne-Marie Lauzon

Cytokines and Airway Smooth Muscle 389(10)

Stephanie A. Shore

Immunoglobulins and the Lung 399(10)

Salem al-Tamemi

Bruce Mazer

Mucus and its Role in Airway Clearance and Cytoprotection 409(8)

Malcolm King

Mucociliary Clearance and Cystic Fibrosis 417(12)

Mark R. Elkins

Peter T.P. Bye

Fluid and Electrolyte Transport in the Airways 429(10)

John W. Hanrahan

Epithelial Function in Lung Injury 439(14)

Yves Berthiaume

Cytokines and Chemokines in Asthma: An Overview 453(16)

Meri K. Tulic

Pierre-Olivier Fiset

Zoe Muller

Qutayba Hamid

Nitric Oxide and the Lung 469(10)

Jennifer S. Landry

David H. Eidelman

Viral Infections and Airway Responsiveness 479(10)

Paolo Renzi

Roles of Lipid Mediators in Acute Lung Injury and Pulmonary Fibrosis 489(6)

Takahide Nagase

Eicosanoids and the Lung 495(14)

William S. Powell

Lung Transplantation 509(16)

Tom Kotsimbos

SECTION VI EXERCISE PHYSIOLOGY

Physiologic Responses to Exercise 525(16)

Hans C. Haverkamp

Jerome A. Dempsey

Jordan D. Miller

Lee M. Romer

Marlowe W. Eldridge

Ventilatory Factors in Exercise Performance in Patients with Chronic Obstructive Pulmonary Disease 541(6)

Carmen Lisboa

Orlando Diaz

Gisella Borzone

Practical Assessment of Exercise Limitation 547(8)

Nicholas C. Duffy

Peter M.A. Calverley

Regulation of Skeletal Blood Flow During Exercise 555(12)

Sabah N.A. Hussain

Alain S. Comtois

Peripheral Muscle Dysfunction in Chronic Obstructive Pulmonary Disease 567(14)

Richard Debigare

Francois Maltais

SECTION VII SLEEP DISORDERED BREATHING

Physiology of the Upper Airways and Upper Airway Obstruction in Disease 581(16)

R. John Kimoff

Cardiovascular Consequences of Sleep-Disordered Breathing 597(8)

Steven R. Coughlin

Peter M.A. Calverley

SECTION VIII CLINICAL RESPIRATORY PHYSIOLOGY

Complexity and Respiration: A Matter of Life and Death 605(6)

Peter T. Macklem

Sex and Gender Differences in Airway Behavior Across the Human Life Span 611(12)

Margaret R. Becklake

Joanne Shannon

Measurement Techniques in Respiratory Mechanics 623(16)

Jason H.T. Bates

Esophageal Pressure Measurement 639(10)

Walter Araujo Zin

Joseph Milic-Emili

Guide to the Evaluation of Pulmonary Function 649(10)

Charles G. Irvin

Single-Breath Carbon Monoxide Diffusing Capacity or Transfer Factor 659(12)

David J. Cotton

Brian L. Graham

Spirometric Predictions of Exercise Limitation in Patients with Chronic Obstructive Pulmonary Disease 671(10)

Joseph Milic-Emili

Nickolaos G. Koulouris

Claudio Tantucci

Determinants of Decline in Lung Function 681(8)

Nicholas R. Anthonisen

Jure Manfreda

Assessment of Respiratory Muscles 689(10)

Guy Czaika

Alejandro Grassino

Assessment of Acid-Base Balance: A Physical-Chemical Approach 699(10)

Sheldon Magder

Airway Hyperresponsiveness 709(12)

Ron Olivenstein

Rame Taha

Assessment of Forced Expiratory Flows in Infants 721(6)

Robert S. Tepper

Debra Turner

Evaluation of the Patient with Occupational Asthma 727(6)

Catherine Lemiere

Physiologic Basis for Pulmonary Rehabilitation of Chronic Obstructive Pulmonary Disease 733(12)

Jean Bourbeau

Helene Perrault

Lung Volume Reduction Surgery 745(10)

Koji Chihara

Diaphragm Responses to Stimulation 755(14)

Francois Bellemare

Claude Poirier

An Introduction to Lung Morphometry 769(8)

R. Heberto Ghezzo
Index 777