Molecular modeling and simulation : an interdisciplinary guide /
作者： Tamar Schlick.
出版社：
简介：Summary:
Publisher Summary 1
The discovery of the DNA double helix in the 1950s prefigured the rise of molecular biology and its many offspring in the next half-century. Genomic sciences now occupy center stage and have linked the biological sciences to the chemical, physical, mathematical and computer sciences. The subject of this book, molecular modeling, represents a sub field of this successful marriage. In an accessible and easy-to-read manner the text surveys three broad topics: biomolecular structure and modeling, molecular mechanics, and simulation techniques. It provides an introduction to the field for scientists and graduate students in many disciplines, including medicine, biology, chemistry, mathematics and computer science.
Publisher Summary 2
This book evolved from an interdisciplinary graduate course entitled Molecular Modeling developed at New York University. Its primary goal is to stimulate excitement for molecular modeling research while introducing readers to the wide range of biomolecular problems being solved bycomputational techniques and to those computational tools. The book is intended for beginning graduate students in medical schools and scientific fields such as biology, chemistry, physics, mathematics, and computerscience. Other scientists who wish to enter, or become familiar, with the field of biomolecular modeling and simulation may also benefit from the broad coverage of problems and approaches.The book surveys three broad areas: biomolecular structure and modeling: current problems and state of computations; molecular mechanics: force field origin, composition, and evaluation techniques; and simulation methods: geometry optimization, Monte Carlo, and molecular dynamicsapproaches. Appendices featuring homework assignments, reading lists, and other information useful for teaching molecular modeling complement the material in the main text. Extensive use of world wide web resources is encouraged, and additional course and text information may be found on a supplementary website.Some praise for Tamar Schlick驴s 驴Molecular Modeling and Simulation: An Interdisciplinary Guide驴:||"The interdisciplinary structural biology community has waited long for a book of this kind which provides an excellent introduction to molecular modeling.驴|驴Harold A. Scheraga, Cornell University||"A uniquely valuable introduction to the modeling of biomolecular structure and dynamics. A rigorous and up-to-date treatment of the foundations, enlivened by engaging anecdotes and historical notes.驴|驴J. Andrew McCammon, Howard Hughes Medical Institute, University of California at San Diego||"I am often asked by physicists, mathematicians and engineers to recommend a book that would be useful to get them started in computational molecular biology. I am also often approached by my colleagues in computational biology to recommend a solid textbook for a graduate course in the area. Tamar Schlick has written the book that I will be recommending to both groups. Tamar has done an amazing job in writing a book that is both suitably accessible for beginners, and suitably rigorous for experts.驴|驴J.J. Collins, Boston University
