简介
M. Bingham 鈥?S. Napier: Overview: Transporters as Targets for Drug Discovery I. Sylte 鈥?A.W. Ravna 鈥?G. Sager 鈥?S.G. Dahl: Membrane Transporters: Structure, Function and Targets for Drug Design G.A. Whitlock 鈥?M.D. Andrews 鈥?A.D. Brown 鈥?P.V Fish 鈥?A. Stobie 鈥?F. Wakehut: Design of Monoamine Reuptake Inhibitors 鈥?SSRIs, SNRIs and NRIs A. Hauck Newman 鈥?J.L. Katz: Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine鈥檚 Mechanism at the Dopamine Transporter Z. Chen 鈥?J. Yang 鈥?P. Skolnick: The Design, Synthesis and Structure-Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors G. Antoni 鈥?J. S枚rensen 鈥?H. Hall: Molecular Imaging of Transporters with Positron Emission Tomography R. Bridges 鈥?S.A. Patel: Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System xc R. Gilfillan 鈥?J. Kerr G. 鈥?Walker 鈥?G. Wishart: Glycine Transporters and Their Inhibitors
目录
Preface to the Series 6
Preface to Volume 4 7
Contents 8
Overview: Transporters as Targets for Drug Discovery 9
Membrane Transporters: Structure, Function and Targets for Drug Design 22
Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs 59
Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine\u2019s Mechanism at the Dopamine Transporter 101
The Design, Synthesis and Structure\u2013Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors 136
Molecular Imaging of Transporters with Positron Emission Tomography 160
Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters EAATs) and the Glutamate/Cystine Exchanger Systen x(c) 192
Glycine Transporters and Their Inhibitors 228
Subject Index 253
Preface to Volume 4 7
Contents 8
Overview: Transporters as Targets for Drug Discovery 9
Membrane Transporters: Structure, Function and Targets for Drug Design 22
Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs 59
Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine\u2019s Mechanism at the Dopamine Transporter 101
The Design, Synthesis and Structure\u2013Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors 136
Molecular Imaging of Transporters with Positron Emission Tomography 160
Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters EAATs) and the Glutamate/Cystine Exchanger Systen x(c) 192
Glycine Transporters and Their Inhibitors 228
Subject Index 253
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