CONTENTS 30
PREFACE 6
PHOTOLEGEND 15
CONFERENCE PARTICIPANTS 16
I. Whole-Organ Mechanics 39
Medial-olivocochlear-efferent effects on basilar-membrane and auditory-nerve responses to clicks: Evidence for a new motion within the cochlea 41
Pulsating fluid motion and deflection of the stereocilia of the inner hair cells due to the electromechanics of the outer hair cells 55
Atomic force microscopic imaging of the intracellular membrane surface of prestin-expressing Chinese hamster ovary cells 64
Action of furosemide on the cochlea modeled with negative feedback 72
Modulation of cochlear mechanics: Model predictions and experimental findings of the effect of changing perilymph osmolarity 79
Measuring the material properties of normal and mutant tectorial membranes 87
Tuning and travel of two tone distortion in intracochlear pressure 94
Response characteristics of the 6 kHz cochlear region of chinchilla 101
Stiffness properties of the reticular lamina and the tectorial membrane as measured in the gerbil cochlea 108
Backward propagation of otoacoustic emission in the cochlea 117
Medial olivocochlear efferent effects on basilar membrane responses to sound 124
Modulation patterns and hysteresis: Probing cochlear dynamics with a bias tone 131
What do the OHCs move with their electromotility? 139
Noise improves peripheral coding of short stimuli 141
Phase and amplitude transfer in the apex of the cochlea 143
Manipulations of chloride ion concentration in the organ of Corti alter outer hair cell electromotility and cochlear amplification 145
Cochlear transducer operating point adaptation 147
Low coherence interferometry of the cochlear partition 149
Superior semicircular canal dehiscence: Mechanisms of air-conducted hearing 151
On the coupling between the incus and the stapes 153
Novel otoacoustic baseline measurement of two-tone suppression behaviour from human ear-canal pressure 155
Is the scala vestibuli pressure influenced by non-piston like stapes motion components? An experimental approach 157
Biomechanics of dolphin hearing: A comparison of middle and inner ear stiffness with other mammalian species 159
II. Hair Cells 163
An experimental preparation of the mammalian cochlea that displays compressive nonlinearity in vitro 165
Ca2+ dynamics in auditory and vestibular hair cells: Monte Carlo simulations and experimental results 176
Electro-mechanical waves in isolated outer hair cell 184
\ 193
Chloride and the OHC lateral membrane motor 200
Fast adaptation in vestibular hair cells depends on myosin-IC 207
The piezoelectric outer hair cell: Bidirectional energy conversion in membranes 214
Outer hair cell mechanics are altered by developmental changes in lateral wall protein content 225
Outer hair cell mechanics reformulated with acoustic variables 232
A model of high-frequency force generation in the constrained cochlear outer hair cell 240
Theoretical analysis of membrane tether formation from outer hair cells 248
Nonlinear responses in prestin knockout mice: Implications for cochlear function 256
Mechanical impedance spectroscopy on isolated cells 264
Heat stress-induced changes in the mechanical properties of mouse outer hair cells 266
Frequency dependence of admittance and conductance of the outer hair cell 269
Modeling outer hair cell high-frequency electromotility in microchamber experiment 271
Chlorpromazine and force relaxation in the cochlear outer hair cell plasma membrane - an optical tweezers study 273
Estimation of the force generated by the outer hair cell motility and the phase of the neural excitation relative to the basilar membrane motion: Theoretical considerations 275
Quantification of calcium buffers in various subcellular locations in rat inner and outer hair cells 278
III. Stereocilia 281
Signal transformation by mechanotransducer channels of mammalian outer hair cells 283
Stereociliary vibration in the guinea pig cochlea 292
The cochlear amplifier: Is it hair bundle motion of outer hair cells? 299
Prestin-lacking membranes are capable of high frequency electro- mechanical transduction 308
Ca2+ changes the force sensitivity of the hair-cell transduction channel 315
Hair bundle mechanics at high frequencies: A test of series or parallel transduction 324
Hair cell transducer channel properties and accuracy of cochlear signal processing 331
Ca2+ permeability of the hair bundle of the mammalian cochlea 333
IV. Emissions 335
Comparative mechanisms of auditory function: Ground sound detection by golden moles 337
DPOAE micro- and macrostructure: Their origin and significance 346
Physical mechanisms of OAE generation and propagation: The hydrodynamic approach 353
Measuring cochlear delays using otoacoustic emissions 360
Distortion product otoacoustic emissions in the amphibian ear 370
Calcium waves connexin permeability defects and hereditary deafness 377
Resonant modes of OAE in the investigation of hearing 384
DPOAE fine structure changes at higher stimulus levels - evidence for a nonlinear reflection component 392
The biophysical origin of otoacoustic emissions 399
Spontaneous otoacoustic emissions in lizards, air pressure effects on them and the question of point sources and global standing waves 407
Development of micro mechanically-relevant hair-cell properties: Late maturation of hair-cell orientation in the basilar papilla of birds 415
Prediction for audiograms and otoacoustic emissions 422
Are click-evoked and stimulus-frequency OAEs generated by the same mechanism? 424
A comparative study of evoked otoacoustic emissions in geckos and humans 426
V. Cochlear Models 429
Cochlear activity in perspective 431
A mechanical-electrical-acoustic model of the cochlea 448
Cochlear coiling and low-frequency hearing 455
Multi-scale model of the organ of Corti: IHC tip link tension 463
A micromechanical model for fast cochlear amplification with slow outer hair cells 471
The cochlea box model once again: Improvements and new results 480
Four counter-arguments for slow-wave OAEs 487
The evolution of multi-compartment cochlear models 496
What stimulates the inner hair cells? 504
Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity 512
Wave propagation by critical oscillators 520
Mechanical energy contributed by motile neurons in the Drosophila ear 527
Short-wavelength interactions between OHCs: A \ 534
Wave propagation in a complex cochlear micromechanics model with curvature 536
A 'Twin-engine' model of level-dependent cochlear motion 538
A hydro-mechanical, biomimetic cochlea: Experiments and models 540
Six experiments on a 1-D nonlinear wave-digital filter modeling of human click-evoked emission data 542
Measurements and models of human inner-ear function with superior semicircular canal dehiscence 544
A new multicompartments model of the cochlea 546
A 3D finite element model of the gerbil cochlea with full fluid-structure interaction 548
Developing a life-sized physical model of the human cochlea 550
Fully micromachined lifesize cochlear model 552
A generic nonlinear model for auditory perception 554
VI. Discussion Section 557
Quick questions 559
Stereocilia and tip links 562
Somatic motility of outer hair cells 564
Waves in the cochlea 567
Fluid flow in the cochlea 570
Traveling waves in the cochlea 572
Are traveling waves in the cochlea going in both directions? 575
Author Index 583