简介
An ideal introduction to the pharmaceutical industry, this book describes the process of bringing a new drug to the marketplace. It explains why, although thousands of compounds show initial promise, only a small handful will be developed for human clinical trials and perhaps only one will become an approved drug. Describing the huge complexities involved, it shows how new molecular understanding and techniques can make the process more targeted and successful. * Includes the new molecular techniques of drug design and development. * Discusses current therapeutic needs. * Covers pharmacoepidemiology and pharmacoeconomics. * Edited by Humphrey Rang, who is also known throughout the world as a co-author of the enormously successful and authoritative textbook, Pharmacology, now in its fifth edition. * Foreword by Daniel Vasella, CEO, Novartis International. * Includes contributors from both the pharmaceutical industry and universities.
目录
Section 1 Introduction and Background
1 The development of the pharmaceutical industry H P Rang p. 3
2 The nature of disease and the purpose of therapy H P Rang p. 19
3 Therapeutic modalities H P Rang and H LeVine p. 33
Section 2 Drug Discovery
4 The drug discovery process: general principles and some case histories H P Rang p. 45
5 Choosing the project H P Rang p. 57
6 Choosing the target H P Rang p. 63
7 The role of genomics and bioinformatics H LeVine and H P Rang p. 77
8 High-throughput screening K Stoeckli and H Haag p. 99
9 The role of chemistry in the drug discovery process C S J Walpole p. 121
10 Pharmacokinetic issues in drug discovery J Ducharme and A J Dudley and R A Thompson p. 141
11 Pharmacology: its role in drug discovery H P Rang p. 163
12 Biopharmaceuticals H LeVine p. 177
13 Patent issues in drug discovery P Grubb p. 195
14 Organization and management of a large drug discovery department P Herrling p. 199
Section 3 Drug Development
15 Drug development: introduction H P Rang p. 221
16 Assessing drug safety H P Rang p. 229
17 Pharmaceutical development H P Rang p. 243
18 Clinical development C Easdale and C W Vose p. 255
19 Protecting the assets: patenting and intellectual property P Grubb p. 273
20 Regulatory affairs I Hagglof and A Holmgren p. 281
21 Marketing the drug R Howell p. 299
Section 4 Facts and Figures
22 Drug discovery and development - facts and figures H P Rang p. 311
Index p. 329
1 The development of the pharmaceutical industry H P Rang p. 3
2 The nature of disease and the purpose of therapy H P Rang p. 19
3 Therapeutic modalities H P Rang and H LeVine p. 33
Section 2 Drug Discovery
4 The drug discovery process: general principles and some case histories H P Rang p. 45
5 Choosing the project H P Rang p. 57
6 Choosing the target H P Rang p. 63
7 The role of genomics and bioinformatics H LeVine and H P Rang p. 77
8 High-throughput screening K Stoeckli and H Haag p. 99
9 The role of chemistry in the drug discovery process C S J Walpole p. 121
10 Pharmacokinetic issues in drug discovery J Ducharme and A J Dudley and R A Thompson p. 141
11 Pharmacology: its role in drug discovery H P Rang p. 163
12 Biopharmaceuticals H LeVine p. 177
13 Patent issues in drug discovery P Grubb p. 195
14 Organization and management of a large drug discovery department P Herrling p. 199
Section 3 Drug Development
15 Drug development: introduction H P Rang p. 221
16 Assessing drug safety H P Rang p. 229
17 Pharmaceutical development H P Rang p. 243
18 Clinical development C Easdale and C W Vose p. 255
19 Protecting the assets: patenting and intellectual property P Grubb p. 273
20 Regulatory affairs I Hagglof and A Holmgren p. 281
21 Marketing the drug R Howell p. 299
Section 4 Facts and Figures
22 Drug discovery and development - facts and figures H P Rang p. 311
Index p. 329
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