International review of cell and molecular biology. V.273 /

Contributors p. ix
1 Cellular Mechanism for Targeting Heterochromatin Formation in Drosophila Joel C. Eissenberg and Gunter Reuter p. 1
1 Introduction p. 2
2 Heterochromatin Domains in the Drosophila Genome p. 3
3 DNA Sequences that Target Heterochromatin p. 16
4 Histone Modifications and Heterochromatin Targeting p. 21
5 Nonhistone Proteins and Heterochromatin Targeting p. 23
6 Nuclear Associations and Heterochromatin in Drosophila p. 31
7 Summary and Perspectives p. 33
References p. 34
2 Import of Nuclear-Encoded Mitochondrial Proteins: A Cotranslational Perspective Afsar U. Ahmed and Paul R. Fisher p. 49
1 Introduction p. 50
2 Mitochondrial Assembly and Protein Import p. 50
3 Mitochondrial Protein Import: Posttranslational or Cotranslational? p. 51
4 Conclusions and Perspectives p. 63
References p. 65
3 Giant Siliceous Spicules From the Deep-Sea Glass Sponge Monorhaphis chuni Xiaohong Wang and Heinz C. Schroder and Werner E. G. Muller p. 69
1 Introduction p. 70
2 Monorhaphis p. 73
3 Giant Basal Spicules: Morphology-Chemistry-Mechanics p. 76
4 Synthesis of Spicules in Demospongiae p. 97
5 Spicule Network in Sponges: A Unique Skeleton p. 102
6 Importance of the Findings for Nanobiotechnological Applications p. 108
7 Concluding Remarks p. 109
References p. 110
4 The Biology of Caveolae: Achievements and Perspectives Marie-Odile Parat p. 117
1 Introduction p. 118
2 Structure of Caveolae p. 118
3 Functions of Caveolae p. 128
4 Caveolin-1 and Caveolae as Therapeutic Targets p. 141
5 Concluding Remarks p. 144
References p. 145
5 Pharmacology of Ciliated Protozoa-Drug (In)Sensitivity and Experimental Drug (Ab)Use Helmut Plattner and Ivonne M. Sehring and Christina Schilde and Eva-Maria Ladenburger p. 163
1 Introduction p. 164
2 Early Success Story-Calmodulin and Its Effect on Ion Transport p. 166
3 Cation Channels, Pumps, and Exchangers p. 168
4 Functions of Specific Components p. 179
5 Cytoskeleton p. 181
6 Signaling, Intracellular Trafficking, and Signal Transduction p. 188
7 Other Factors and Tools p. 195
8 Concluding Remarks p. 199
References p. 203
6 Cell and Molecular Biology of Nuclear Actin Wilma A. Hofmann p. 219
1 Introduction p. 220
2 Biological Functions of Nuclear Actin p. 223
3 Mechanisms of Actin Function in the Nucleus p. 235
4 Concluding Remarks p. 249
References p. 250
7 Small Ubiquitin-Like Modifiers in Cellular Malignancy and Metastasis Keun II Kim and Sung Hee Baek p. 265
1 Introduction p. 266
2 SUMOs and SUMO-Modifying Enzymes p. 267
3 Roles of SUMOs in Cancer Development, Progression, and Metastasis p. 286
4 Concluding Remarks p. 297
References p. 298
8 Phosphoinositide Signaling Pathways: Promising Role as Builders of Epithelial Cell Polarity Ama Gassama-Diagne and Bernard Payrastre p. 313
1 Introduction p. 314
2 Phosphoinositides: Structure, Metabolism, and Functions p. 315
3 Phosphoinositides as Key Determinants in Building Polarity p. 323
4 Concluding Remarks p. 334
References p. 335
Index p. 345