医学细胞生物学 MEDICAL CELL BIOLOGY（英文原版改编版）（留学生与双语教学用）

Chapter 1 Tools of the Cell Biologist............................1
MICROSCOPY: ONE OF THE EARLIEST TOOLS
OF THE CELL BIOLOGIST...................................... 1
MORE TOOLS OF CELL BIOLOGY......................... 11
SUMMARY...................................................................16
SUGGESTED READINGS........................................... 16
Chapter 2 Cell Membranes........................................... 17
THE MOLECULAR STRUCTURE OF CELL
MEMBRANE............................................................ 19
MEMBRANE TRANSPORT OF SMALL
MOLECULES........................................................... 27
SUMMARY................................................................... 31
SUGGESTED READINGS........................................... 32
Chapter 3 Cytoskeleton.................................................. 33
MICROFILAMENTS.................................................... 33
INTERMEDIATE FILAMENTS................................. 40
MICROTUBULES......................................................... 43
SUMMARY................................................................... 48
SUGGESTED READINGS........................................... 48
Chapter 4 Organelle Structure and Function......... 49
THE NUCLEUS............................................................ 50
ENDOPLASMIC RETICULUM................................. 51
THE GOLGI COMPLEX.............................................. 66
ENDOCYTOSIS, ENDOSOMES, AND
LYSOSOMES............................................................ 73
MITOCHONDRIA....................................................... 77
PEROXISOMES............................................................ 87
SUMMARY................................................................... 88
SUGGESTED READINGS........................................... 89
Chapter 5 Cell Nucleus and Gene Expression......... 90
CELL NUCLEUS.......................................................... 90
DNA REPLICATION AND REPAIR ARE
CRITICAL NUCLEAR FUNCTIONS................... 98
GENE EXPRESSION.................................................. 104
SUMMARY................................................................. 116
SUGGESTED READINGS......................................... 116
Chapter 6 Cell Adhesion and the Extracellular
Matrix........................................................... 117
CELL ADHESION...................................................... 117
INTERCELLULAR JUNCTIONS............................. 119
CELL ADHESION HAS MANY IMPORTANT
ROLES IN TISSUE FUNCTION.......................... 128
CELL ADHESION RECEPTORS TRANSMIT
SIGNALS THAT REGULATE CELL
BEHAVIOR.........................................................................133
EXTRACELLULAR MATRIX................................... 134
SUMMARY.................................................................140
SUGGESTED READINGS......................................... 141
Chapter 7 Intercellular Signaling............................. 142
GENERAL MODES OF INTERCELLULAR
SIGNALING........................................................... 142
HORMONES............................................................... 144
XII 医学细胞生物学Meeddiiccaall Ceellll Biioollooggyy
GROWTH FACTORS................................................ 146
GASES: NITRIC OXIDE AND CARBON
MONOXIDE........................................................... 148
NEUROTRANSMITTERS......................................... 150
SUMMARY................................................................. 154
SUGGESTED READINGS......................................... 155
Chapter 8 Cell Signaling Events................................ 156
SIGNALING IS OFTEN MEDIATED BY CELLSURFACE
RECEPTORS....................................... 156
RECEPTOR TYROSINE KINASES AND RASDEPENDENT
SIGNAL TRANSDUCTION...... 157
SIGNALING BY CATALYTIC RECEPTORS/
SERINE-THREONINE KINASES....................... 160
SIGNALING BY NONKINASE RECEPTORS....... 163
SIGNALING BY G-PROTEIN-COUPLED
RECEPTORS INVOLVES CLEAVAGE
OF GUANOSINE TRIPHOSPHATE TO
GUANOSINE DIPHOSPHATE.......................... 166
SIGNALING BY STEROID HORMONE
RECEPTORS REQUIRES LIGAND
INTERACTION WITHIN THE
CYTOPLASM OR NUCLEUS............................. 167
OTHER SIGNALING PATHWAYS
SIGNALING BY THE RENINANGIOTENSIN-
ALDOSTERONE SYSTEM....169
SIGNALING BY THE JAK/STAT PATHWAY..... 170
CALCIUM/CALMODULIN SIGNAL
TRANSDUCTION................................................. 170
SIGNALING BY ION CHANNEL RECEPTORS..........171
SUMMARY................................................................. 172
SUGGESTED READINGS......................................... 172
Chapter 9 The Cell Cycle and Cancer..................... 173
CELL CYCLE: HISTORY.......................................... 173
THE CELL CYCLE IS REGULATED BY
CYCLIN AND RELATED PROTEINS............... 174
MITOSIS...................................................................... 176
MEIOSIS ..................................................................... 179
SENSORS RECOGNIZE SITES OF DNA
DAMAGE............................................................... 181
CELL-CYCLE ALTERATIONS AND CANCER ..........183
SUMMARY................................................................. 184
SUGGESTED READINGS......................................... 184
Chapter 10 Programmed Cell Death........................ 185
DISTINCT FORMS OF PROGRAMMED CELL
DEATH................................................................... 186
NEUROTROPHIN RECEPTORS............................. 189
CASPASES.................................................................. 191
SIGNALING PATHWAYS THAT PROMOTE
CELL SURVIVAL.................................................. 197
APOPTOSIS AND HUMAN DISEASE................... 200
SUMMARY................................................................. 201
SUGGESTED READINGS......................................... 201