International review of cell and molecular biology. V.271 /

Contributors p. ix
1 Genetic Models of Cancer in Zebrafish James F. Amatruda and E. Elizabeth Patton p. 1
1 Introduction p. 2
2 Molecular Relevance of Zebrafish Cancer to Human Disease p. 5
3 Forward Genetic Screens p. 6
4 Targeted Cancer Models in Zebrafish p. 10
5 Xenotransplantation p. 23
6 Chemical Genetics: Small-Molecule Screening in Zebrafish p. 26
7 Summary p. 27
References p. 28
2 Cellular and Molecular Biological Aspects of Cervical Intraepithelial Neoplasia Fjodor Kisseljov and Olga Sakharova and Tatjana Kondratjeva p. 35
1 Introduction p. 36
2 Cervical Cancer as a Unique Model of Human Carcinogenesis p. 37
3 Biology of Cervical Neoplasias p. 40
4 Cellular Aspects of Cervical Tumors Progression p. 44
5 Molecular Aspects of Cervical Carcinogenesis p. 51
6 Conclusions p. 75
References p. 76
3 Vesicle, Mitochondrial, and Plastid Division Machineries with Emphasis on Dynamin and Electron-Dense Rings T. Kuroiwa and O. Misumi and K. Nishida and F. Yagisawa and Y. Yoshida and T. Fujiwara and H. Kuroiwa p. 97
1 Introduction p. 98
2 Structural Similarities Among Mitochondrial, Plastid, and Vesicle Division Machineries p. 101
3 Vesicle Division Machinery p. 107
4 Bacterial, Microbody (Peroxisome), Mitosome, and Hydrogenosome Division Machineries p. 111
5 Mitochondrial Division Machinery p. 118
6 Plastid (Chloroplast) Division Machinery p. 128
7 Isolation of Organelle Division Machinery and Its Significance p. 137
8 Concluding Remarks p. 143
References p. 144
4 Retromer: Multipurpose Sorting and Specialization in Polarized Transport Marcel Verges p. 153
1 Introduction: Basic Concepts on Coat-Mediated Vesicular Transport p. 154
2 Retromer's Assembly and Functioning p. 155
3 Multiple Roles of Retromer: Models of Study p. 160
4 Polarized Transport Mediated by Retromer p. 167
5 Implication of Retromer and Sorting Nexins in Other Aspects of Polarity p. 179
6 Concluding Remarks p. 184
References p. 185
5 Translational Control of Gene Expression: From Transcripts to Transcriptomes Daniel H. Lackner and Jurg Bahler p. 199
1 Introduction p. 200
2 Preparation for Translation: RNA Processing and Export p. 202
3 Regulation of Translation p. 204
4 Emerging Concepts in Translational Regulation p. 219
5 Global Approaches to Identify Targets of Posttranscriptional Gene Regulation p. 227
6 Concluding Remarks p. 237
References p. 238
6 Phagocytosis and Host-Pathogen Interactions in Dictyostelium with a Look at Macrophages Salvatore Bozzaro and Cecilia Bucci and Michael Steinert p. 253
1 Introduction p. 254
2 The Dynamics of Phagocytosis p. 257
3 Cellular Mechanisms of Phagocytosis p. 260
4 Regulatory Pathways Controlling Phagocytosis p. 268
5 Host-Pathogen Interactions: A Versatile New Model Host p. 281
6 Concluding Remarks p. 288
References p. 289
7 Mechanobiology of Adult and Stem Cells James H.-C. Wang and Bhavani P. Thampatty p. 301
1 Introduction p. 303
2 Application of External Mechanical Forces to Cells p. 304
3 Cell-Generated Mechanical Forces p. 306
4 Mechanobiological Responses of Cells p. 311
5 Mechanotransduction Mechanisms p. 329
6 Concluding Remarks p. 332
References p. 334
Index p. 347