International review of cell and molecular biology. V.278 /

Contributors p. ix
1 Macromolecutar Trafficking and Immune Evasion in African Trypanosomes Mark C. Field and Jennifer H. Lumb and Vincent O. Adung'a and Nicola G. Jones and Markus Engstler p. 1
1 General Overview of the Trypanosome Life Cycle p. 3
2 Immune Evasion Mechanisms p. 5
3 Endocytrc Pathways p. 16
4 Developmental Remodeling and Signaling p. 27
5 Sorting Signals p. 28
6 Secretory Protein Folding and Exocytosis p. 32
7 Golgi Apparatus; Functions and Replication p. 39
8 Ubiquitylation and Endocytosis of Trans-Membrane Domain Proteins p. 42
9 Evolution of the Trypanosome Endomembrane System p. 46
10 Conclusions and Future Perspectives p. 50
Acknowledgments p. 51
References p. 52
2 Biological and Biophysical Properties of Vascular Connexin Channels Scott Johnstone and Brant Isakson and Darren Locke p. 69
1 Introduction p. 71
2 The Vasculature p. 72
3 Connexin Channels p. 75
4 Gap Junctional Communication Pathways in the Vasculature p. 82
5 Permeability of Vascular Connexin Channels p. 87
6 Involvement of Connexins in Vascular Diseases p. 101
7 Concluding Remarks p. 104
Acknowledgments p. 105
References p. 105
3 Genotype-Phenotype Mapping: Developmental Biology Confronts the Toolkit Paradox Joel Atallah and Ellen Larsen p. 119
1 Introduction p. 120
2 Understanding the Genotype-Phenotype Relationship p. 121
3 From Sequence to Form p. 125
4 Beyond Sequence p. 135
5 Case Study for Parsing Gene, Cell and Self-Organizing Roles in Morphogenesis p. 138
6 Conclusion p. 142
Acknowledgments p. 142
References p. 142
4 Role of Spindle Asymmetry in Cellular Dynamics Yves Barral and Dimitris Liakopoulos p. 149
1 Introduction p. 150
2 Spindle Asymmetry and Control of Cell Cycle p. 152
3 Spindle Asymmetry During Asymmetric Cell Divisions p. 174
4 Concluding Remarks p. 201
References p. 203
5 Cell Adhesion in Amphibian Gastrulation Rudolf Winklbauer p. 215
1 Introduction p. 216
2 Characteristics of Amphibian Gastrulation p. 217
3 Gastrula Tissue as a Liquid: Cell Adhesion, Cell Sorting, Boundary Formation, and Tissue Positioning p. 223
4 Collective Cell Migration, Cell Rearrangement, and Intercellular Migration p. 249
5 Conclusion p. 260
Acknowledgments p. 261
References p. 261
6 Molecular and Cell Biology of Testicular Germ Cell Tumors Paolo Chieffi and Renato Franco and Giuseppe Portella p. 277
1 Introduction p. 278
2 Epidemiology and Risk Factors p. 279
3 Histopathology p. 280
4 Prognostic and Diagnostic Markers p. 294
5 Therapy p. 297
6 Conclusions and Perspectives p. 301
Acknowledgments p. 301
References p. 302
7 Polarity Proteins and Cell-Cell Interactions in the Testis Elissa W.P. Wong and C. Yan Cheng p. 309
1 Introduction p. 310
2 Rho GTPases and Cell-Cell Interactions in the Testis: Cdc42 p. 315
3 Polarity Proteins and Cell-Cell Interactions in the Testis p. 327
4 The Apical ES-BTB-Basement Membrane Functional Axis in the Seminiferous Epithelium that Coordinates the Cellular Events of Spermiation and BTB Restructuring During the Seminiferous Epithelial Cycle of permatogenesis: The Role of Polarity Proteins in Mediating the Apical ES-BTB-Basement Membrane Axis p. 335
5 Roles of Polarity Proteins in Coordinating the Opposing Effects of Cytokines and Testosterone in Primary Preleptotene Spermatocyte Transit at the BTB p. 339
6 Concluding Remarks and Future Perspectives p. 341
Acknowledgment p. 342
References p. 342
Index p. 355