Transducing the genome : information, anarchy, and revolution in the biomedical sciences /
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作 者:Gary Zweiger.
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ISBN:9780071369800
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简介
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What has made the Human Genome Project so deeply appealing? In one sense, it's just another large-scale, big-budget effort to keep a gang of nerds busy and out of trouble for a few years. Geneticist Gary Zweiger looks askance at this and explains how the confluence of information systems, big science, and business exemplified by the HGP is actually accelerating the pace of beneficial change for all people. Transducing the Genome: Information, Anarchy, and Revolution in the Biomedical Sciences draws deeply on Zweiger's experience in biological science and biotech commerce to illuminate the scientific, economic, and legal issues relevant to the search for a more complete understanding of human genetics. Brimming with pro-capitalist optimism, he believes that the information revolution spawned the biotech explosion and will soon lead to better, cheaper solutions to a very broad range of health problems:
Knowledge of our internal information network will come mostly from an explosion of new genomic database analyses. A growing army of mathematicians and information scientists will develop increasingly powerful and more useful algorithms and computational processes for finding biomedical knowledge in these databases. A growing regiment of biologists and medical professionals with training in mathematics and information sciences will lead these knowledge discovery missions.
Zweiger assuages the reader's fears of gene patents with a brief foray into intellectual property law. It does seem unlikely that biotech patents will pose any more problems than standard pharmaceutical company practice. Combining scientific, legal, and business expertise, Transducing the Genome provides the most comprehensive overview of the birth of biotech yet written. --Rob Lightner
Book Description
In this important book, a scientist gives us an inside account of the historic paradigm shift underway in the life sciences as a result of The Human Genome Project, and provides a philosophical framework in which to understand biology and medicine as information sciences. In a story told on many fascinating levels, Gary Zweiger introduces us to the visionaries who first understood genes as information carriers and chronicles how their early efforts led to the birth of the new science of genomics.
He provides insights into the uneasy collaboration of private, government, and academic efforts, the role of the pharmaceutical companies, and the influence of venture capitalists on one of the most ambitious and potentially significant scientific undertakings in history. Most importantly, he explores the profound impact that the transducing of biological information into a digital format already has had on biological research and medicine, and the equally profound effect it is sure to have on our understanding of ourselves and all living creatures.
目录
Copyright
Contents
Acknowledgments
Introduction
1 Cancer, Computers, and a “List-Based” Biology
2 Information and Life
3 Behold the Gene
4 Working with Genes One at a Time
5 The Database
6 Getting the Genes
7 Prospecting for Genes with ESTs
8 ESTs, the Gene Race, and Moore’s Law
9 The End Game
10 Human Genome History
11 Comparing Human Genomes
12 A Paradigm in Peril
13 The Ancient Internet— Information Flow in Cells
14 Accessing the Information Output of the Genome
15 The Genomics Industry
16 The SNP Race
17 From Information to Knowledge
18 The Final Act
19 Future Prospects
Appendix
Glossary
Notes
Index
About the Author
Transducing the genome : information, anarchy, and revolution in the biomedical sciences /
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