Fluoroquinolone antibiotics /

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作者：A.R. Ronald, D.E. Low.

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ISBN：9783764365912

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简介

简介

Summary: Publisher Summary 1 The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their effectiveness for respiratory, urinary, sexually transmitted, skin, soft tissue, bone and joint infections, infections of the eyes, ears, nose and throat, and less common infections such as mycobacterial, Brucella and others are reviewed. Also described is their use in pediatric, oncology and immunocompromised patients. The quinolone story continues to be intriguing with exciting future implications.This monograph is an important comprehensive review and update for researchers and clinicians in pharmacology, clinical medicine, molecular and cell biology, epidemiology and the pharmaceutical industry.

Table Of Contents:
List of contributors VII
Preface IX
Gerard Sheehan and Nicholas S. Y. Chew

The history of quinolones 1(10)
Lester A. Mitscher and Zhenkun Ma

Structure-activity relationships of quinolones 11(38)
Pak-Leung Ho and Vincent C. C. Cheng

Epidemiology and mechanisms of resistance 49(24)
Lionel A. Mandell

Improved safety profile of newer fluoroquinolones 73(14)
George G. Zhanel and Aymara M. Noreddin

Pharmacokinetics and pharmacodynamics (PKIPD) of fluoro quinolones: tools for combating bacteria and preventing resistance 87(20)
James R. Johnson

Fluoroquinolones in urinary tract infection 107(14)
Sarah A. Wyllie and Geoffrey L. Ridgway

The quinolones and sexually transmitted infections 121(16)
Anthony W. Chow

Gastrointestinal and intraabdominal infections 137(30)
Eugene Leibovitz and Ron Dagan

The quinolones in otitis media and upper respiratory infections 167(10)
Thomas J. Marrie

Quinolones in pneumonia 177(12)
Donald E. Low

Fluoroquinolones for the treatment of respiratory tract infections other than pneumonia 189(16)
John M. Embil

Quinolones for the treatment of skin, soft tissue, bone and prosthetic joint infections 205(14)
Helen Giamarellou and Anastasia Antoniadou

The role of fluoroquinolones in the therapy and prophylaxis of neutropenic patients with cancer 219(20)
Ziad A. Memish and Manuel W. Mah

Less usual indications: Mycobacterial, Brucella, Yersinia, Francisella and other infections 239(12)
Allan R. Ronald and Donald E. Low

The quinolones: future prospects 251(4)
Index 255

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