Swine in the laboratory : surgery, anesthesia, imaging, and experimental techniques / 2nd ed.
副标题：无
作 者：M. Michael Swindle ; illustrator, Richard Hughes.
分类号：
ISBN：9780849392788
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简介
Summary:
Publisher Summary 1
Given the complexity of porcine anatomy and the frequent appearance of swine in veterinary, agricultural and biomedical labs, newcomers have a steep learning curve and little time to learn pigs properly. This reference gives students comprehensive directions to preoperative care all the way through to recovery in a variety of experimental and practical settings, covering biology, handling, husbandry, anatomy, anesthetics and analgesia, perioperative care, wound closure and integument, and directions to procedures throughout the body systems, including the gastrointestinal, liver and biliary, urinary and reproductive, cardiovascular and pulmonary. Sections address catheterization and imagery endoscopy, xeno-transplantation and transgenic technologies, toxicology, and radiobiology. The illustrations and photographs are particularly well done. Annotation 漏2007 Book News, Inc., Portland, OR (booknews.com)
目录
Biology, Handling, Husbandry, and Anatomy p. 1
Introduction p. 1
Breed Selection p. 1
Biology p. 4
Taxonomy and Nomenclature p. 5
Reproduction p. 6
Growth and Development p. 6
Nutrition p. 7
Hematology p. 8
Behavior p. 9
Husbandry p. 9
Disease Prevention p. 14
Restraint and Handling p. 15
Administration of Medications and Injections p. 16
General Anatomy p. 25
Model Selection p. 30
References p. 32
Anesthesia, Analgesia, and Perioperative Care p. 35
Introduction p. 35
Anesthetic Induction and Animal Prep Room Activities p. 35
Endotracheal Intubation p. 40
Special Perioperative Considerations p. 42
Preoperative Fasting p. 42
Intravenous Fluid Administration p. 43
Thermal Support p. 43
Cardiac Monitoring and Arrhythmias p. 43
Specialized Intraoperative Monitoring p. 45
Malignant Hyperthermia p. 47
Paralytic Agents p. 47
Anesthetic Monitoring p. 48
Ventilation Rates p. 48
Postoperative Monitoring p. 49
Pain Assessment p. 49
Nonpharmacological Control of Pain and Distress p. 49
Chronic Pain and Distress p. 51
Preanesthetic Agents p. 53
Anticholinergics p. 53
Tranquilizers and Sedatives p. 53
Injectable Anesthetic Agents p. 53
Dissociative Agents and Combinations p. 54
Barbiturates p. 56
Opioid Infusions p. 57
Miscellaneous Agents p. 57
Inhalant Anesthetics p. 59
Cardiopulmonary Bypass (CPB) p. 61
Cardiopulmonary Bypass Equipment p. 63
Surgery p. 63
Monitoring and Perfusionist Parameters p. 63
Anesthesia p. 64
Weaning from CPB p. 64
Postoperative Considerations p. 65
Regional Low-Flow Perfusion and Neural Protection p. 65
Analgesics p. 65
Opioids p. 66
Nonsteroidal Anti-Inflammatory Drugs p. 68
Reversal Agents for Injectable Anesthetics, Sedatives, and Analgesics p. 69
Local and Regional Analgesia p. 69
Commonly Recommended Protocols p. 70
Nonsurvival Teaching Protocols p. 70
General Surgery (without Physiological Measurements) p. 71
General Surgery (with Physiological Measurements) p. 71
Cardiothoracic Surgery (with Cardiovascular Manipulations) p. 71
Cardiothoracic Surgery (with Cardiovascular Compromise) p. 71
Coronary Artery Catheterization p. 72
General Physiological Effects of Anesthetics p. 72
Dissociative Agents p. 72
Barbiturates p. 72
Sedatives/Hypnotics p. 72
Opioids p. 74
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) p. 74
Inhalant Anesthetics p. 74
Euthanasia p. 75
References p. 75
Wound Closure and Integument p. 81
General Principles and Surgical Preparation p. 81
Suture Selection for Wound Closure p. 82
Wound Closure and Bandaging Techniques p. 86
Skin Flaps and Grafts p. 91
Random Skin Flaps p. 92
Arterial Skin Flaps p. 93
Myocutaneous Flaps p. 93
Wound-Healing Models p. 94
References p. 95
Gastrointestinal Procedures p. 97
Surgical Anatomy p. 97
General Principles of Abdominal Surgery p. 101
Postoperative Care p. 104
Gastrotomy and Gastrostomy Techniques p. 106
Pyloroplasty p. 108
Enterotomy and Intestinal Fistulation p. 108
Intestinal Infusion Catheter Implantation p. 110
Intestinal Anastomosis p. 112
Intestinal Diversion or Intestinal Bypass p. 113
Colonic Anastomosis and Fistulation p. 115
Total Colectomy p. 116
Rectal Prolapse p. 116
Intestinal and Multivisceral Transplantation p. 117
Vagotomy p. 119
Intraperitoneal Sepsis, Septic Shock, and Hemorrhagic Shock p. 120
References p. 120
Liver and Biliary System p. 123
Surgical Anatomy and General Principles of Surgery p. 123
Cholecystectomy p. 126
Cannulation or Constriction of the Common Bile Duct p. 128
Partial Hepatectomy, Liver Biopsy, and Intrahepatic Cannulation p. 132
Liver Transplantation p. 133
Donor Liver p. 134
Allograft and Autograft Implantation p. 134
Segmental Liver Grafts p. 135
Hepatic Xenoperfusion p. 135
References p. 137
Pancreas and Spleen p. 141
Surgical Anatomy and General Principles of Surgery p. 141
Pancreatectomy, Islet Cell Ablation, and Diabetes p. 141
Segmental Pancreatectomy, Pancreatic Transplant, and Islet Cell Isolation p. 147
Pancreatic Duct Ablation, Cannulation, and Pancreatitis p. 149
Splenectomy, Splenic Vascular Catheterization, and Splenic Transplantation p. 150
References p. 153
Urinary System and Adrenal Glands p. 157
General Principles of Surgery and Surgical Anatomy p. 157
Nephrectomy p. 161
Partial Nephrectomy and Intrarenal Surgery p. 163
Renal Transplant p. 164
Cystotomy and Ureteral Diversion p. 166
Urinary Tract Obstruction, Reflux Nephropathy, and Hydronephrosis p. 167
Perineal Urethrostomy and Urinary Diversion p. 168
Preputial Diverticulum Ablation p. 169
Adrenalectomy p. 172
References p. 172
The Reproductive System p. 175
General Principles of Surgery p. 175
Castration (Orchiectomy) and Vasectomy p. 177
Ovariohysterectomy, Hysterectomy, Ovariectomy, or Tubal Ligation p. 177
Cesarean Section (C-Section) p. 179
Fetal Surgery and Fetal Catheterization p. 180
Prolapse of the Reproductive Tract p. 187
Endometriosis p. 190
Pelvic Adhesions p. 191
Artificial Insemination and Embryo Transfer p. 191
Mammectomy p. 192
References p. 192
Cardiothoracic and Vascular Surgery/Chronic Intravascular Catheterization p. 195
General Principles of Cardiothoracic Surgery and Surgical Anatomy p. 195
Pulmonary System p. 211
Tracheostomy and Tracheotomy p. 211
Pneumonectomy and Lobectomy p. 212
Pulmonary Transplant p. 214
Cardiovascular System p. 214
Peripheral Vascular Cannulation and Chronic Catheterization Techniques p. 214
General Principles p. 214
General Surgical Principles for Catheterization p. 215
Catheter Design p. 218
Catheter Maintenance p. 220
Neck Vessels: External and Internal Jugular Veins and Carotid Artery p. 221
Leg Vessels p. 227
Portal Vein p. 228
Other Blood Vessels p. 231
Postoperative Considerations p. 231
Vascular Anastomosis p. 231
Arteriovenous and Venovenous Fistulas and Vascular Shunts p. 234
Atriotomy and Ventriculotomy p. 235
Valvular Surgery p. 236
Aortic and Pulmonary Artery Banding, Ligation of the Ductus Arteriosus, and Chronic Instrumentation p. 238
Myocardial Infarction and Associated Arrhythmias p. 240
Vascular Aneurysms p. 243
Bifurcation Aneurysms p. 243
Terminal Aneurysms p. 244
Fusiform Aneurysms p. 244
Wide-Necked Aneurysms p. 244
Coarctation of the Aorta p. 245
Cardiomyoplasty p. 246
Epicardial Pacemaker and Device Implantation p. 247
Heart and Heart-Lung Transplantation p. 249
Heart Transplant p. 249
Donor p. 249
Recipient p. 249
Heart-Lung Transplant p. 250
Miscellaneous Thoracic Procedures p. 250
Thoracic Duct Cannulation p. 250
Esophageal Surgery p. 251
References p. 252
Head and Neck Surgery/Central Nervous System p. 261
General Principles of Surgery and Surgical Anatomy p. 261
Dental Procedures and Tusk Trimming p. 272
Maxillofacial and Craniotomy Procedures p. 274
Ocular Surgery p. 275
Pharyngostomy Tubes p. 278
Thyroidectomy p. 278
Parathyroidectomy p. 278
Hypophysectomy p. 279
Spinal Cord Ischemia and Hemorrhage p. 280
Stroke Models p. 281
Cerebrospinal Fluid (CSF) Collection and Epidural Injection p. 281
Epidural Injection p. 282
CSF Collection p. 283
References p. 284
Musculoskeletal System and Orthopedic Procedures p. 289
General Principles of Surgery and Surgical Anatomy p. 289
Amputation of a Digit and Hoof Trimming p. 290
Tendon and Ligament Repair p. 291
Tail Amputation p. 292
Hernia Repair p. 292
Surgical Approaches to Bones and Joints p. 293
Foreleg p. 294
Hind Limb p. 294
Vertebral Column p. 295
Bone Marrow Aspiration p. 295
References p. 297
Cardiovascular Catheterization, Electrophysiology, and Imaging Laboratory Procedures p. 299
Introduction p. 299
Peripheral Vascular Access for Cardiovascular Catheters p. 299
Anesthetics and Adjunct Drugs p. 304
Hemodynamics p. 305
Angioplasty Balloon Techniques, Intravascular Device Implantations, and Restenosis p. 307
Atherosclerosis p. 314
Electrophysiology and Electrocardiography (ECG) and Telemetry p. 316
Pacemaker Implantation and Endocardial Pacemaker Leads p. 324
Conduction System Ablation p. 328
Angiography p. 329
Echocardiography p. 334
References p. 340
Endoscopic, Laparoscopic, and Minimally Invasive Surgery p. 345
Introduction p. 345
General Considerations p. 345
Anatomic Considerations for Flexible Endoscopic Research p. 345
Performing Endoscopy p. 346
Endoscopic Retrograde Cholangiopancreatography (ERCP) p. 349
Endoscopic Hemostasis (Gastrointestinal Bleeding) p. 350
Colonoscopy p. 351
Laryngoscopy and Bronchoscopy p. 351
Training in Flexible Endoscopy p. 351
Laparoscopic, Celioscopic, and Thoracoscopic Surgery p. 353
Cholecystectomy p. 354
Small Intestinal Anastomosis p. 354
Colonic Anastomosis p. 355
Vagotomy and Hiatal Procedures p. 355
Nephrectomy and Renal Ablation p. 356
Inguinal Herniorrhaphy p. 356
Appendectomy p. 357
Splenectomy p. 357
Adrenalectomy p. 357
Urinary Bladder Procedures p. 357
Reproductive Procedures p. 357
Thoracoscopy p. 357
Laparoscopic Ultrasonography p. 358
Postoperative Care for Laparoscopic and Endoscopic Procedures p. 358
Natural Orifice Transluminal Endoscopic Surgery (NOTES) p. 358
Surgical Robotics p. 359
References p. 360
Xenotransplantation and Transgenic Technologies p. 365
Introduction p. 365
Ethical Considerations p. 365
Immunologic and Physiological Considerations p. 366
Strategies for Development of Transgenic Animals p. 367
Regulatory Guidelines p. 367
Public Health Considerations p. 368
Management and Husbandry Strategies p. 369
Other Considerations p. 369
References p. 370
Toxicology p. 373
Introduction p. 373
Domestic Pigs and Minipigs p. 373
Strains of Minipigs p. 373
Pharmacokinetics and Metabolism p. 374
Repeat Dose Toxicology p. 374
Routes of Dose Administration p. 375
Observations and Sampling Techniques p. 375
Necropsy Procedure p. 375
Histopathology p. 376
Reproductive Toxicology p. 377
Juvenile Studies p. 377
Regulatory Acceptance p. 379
Conclusions for Toxicological Models p. 379
Acknowledgments p. 379
References p. 380
Radiobiology p. 383
References p. 384
Imaging Techniques: CT, MRI, and PET Scanning p. 387
Scanners p. 387
Anesthesia p. 387
Surgery p. 388
Monitoring p. 388
Scanning Procedures p. 389
Technical Information for Each of the Images on the Attached DVD p. 389
Instructions for Opening the DVD p. 389
Contrast Radiograph of the Cerebral Artery p. 390
MRI (Magnetic Resonance Imaging) p. 391
PET (Positron Emission Tomography) p. 392
Dopamine Receptors p. 393
PET Scan of a 40-kg Female Pig after Injection of [superscript 18]F Galactose p. 394
CT and PET/CT of a Domestic Pig p. 395
Ossabaw Island Miniature Swine: Cardiometabolic Syndrome Assessment p. 397
Introduction p. 397
Characterization of the Model p. 398
Summary and Conclusions p. 399
Acknowledgments p. 400
References p. 400
Appendix p. 403
Growth Charts, Nutrition, and Physiological Parameters p. 405
Hematology and Serum Chemistry p. 409
Organ Weights and Measurements p. 430
Reproductive Parameters p. 436
Fetal Parameters p. 439
Section 6: Animal Health and General References p. 446
General Reference Textbooks for Swine p. 449
Review Articles p. 449
Web Sites p. 450
Index p. 451
Introduction p. 1
Breed Selection p. 1
Biology p. 4
Taxonomy and Nomenclature p. 5
Reproduction p. 6
Growth and Development p. 6
Nutrition p. 7
Hematology p. 8
Behavior p. 9
Husbandry p. 9
Disease Prevention p. 14
Restraint and Handling p. 15
Administration of Medications and Injections p. 16
General Anatomy p. 25
Model Selection p. 30
References p. 32
Anesthesia, Analgesia, and Perioperative Care p. 35
Introduction p. 35
Anesthetic Induction and Animal Prep Room Activities p. 35
Endotracheal Intubation p. 40
Special Perioperative Considerations p. 42
Preoperative Fasting p. 42
Intravenous Fluid Administration p. 43
Thermal Support p. 43
Cardiac Monitoring and Arrhythmias p. 43
Specialized Intraoperative Monitoring p. 45
Malignant Hyperthermia p. 47
Paralytic Agents p. 47
Anesthetic Monitoring p. 48
Ventilation Rates p. 48
Postoperative Monitoring p. 49
Pain Assessment p. 49
Nonpharmacological Control of Pain and Distress p. 49
Chronic Pain and Distress p. 51
Preanesthetic Agents p. 53
Anticholinergics p. 53
Tranquilizers and Sedatives p. 53
Injectable Anesthetic Agents p. 53
Dissociative Agents and Combinations p. 54
Barbiturates p. 56
Opioid Infusions p. 57
Miscellaneous Agents p. 57
Inhalant Anesthetics p. 59
Cardiopulmonary Bypass (CPB) p. 61
Cardiopulmonary Bypass Equipment p. 63
Surgery p. 63
Monitoring and Perfusionist Parameters p. 63
Anesthesia p. 64
Weaning from CPB p. 64
Postoperative Considerations p. 65
Regional Low-Flow Perfusion and Neural Protection p. 65
Analgesics p. 65
Opioids p. 66
Nonsteroidal Anti-Inflammatory Drugs p. 68
Reversal Agents for Injectable Anesthetics, Sedatives, and Analgesics p. 69
Local and Regional Analgesia p. 69
Commonly Recommended Protocols p. 70
Nonsurvival Teaching Protocols p. 70
General Surgery (without Physiological Measurements) p. 71
General Surgery (with Physiological Measurements) p. 71
Cardiothoracic Surgery (with Cardiovascular Manipulations) p. 71
Cardiothoracic Surgery (with Cardiovascular Compromise) p. 71
Coronary Artery Catheterization p. 72
General Physiological Effects of Anesthetics p. 72
Dissociative Agents p. 72
Barbiturates p. 72
Sedatives/Hypnotics p. 72
Opioids p. 74
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) p. 74
Inhalant Anesthetics p. 74
Euthanasia p. 75
References p. 75
Wound Closure and Integument p. 81
General Principles and Surgical Preparation p. 81
Suture Selection for Wound Closure p. 82
Wound Closure and Bandaging Techniques p. 86
Skin Flaps and Grafts p. 91
Random Skin Flaps p. 92
Arterial Skin Flaps p. 93
Myocutaneous Flaps p. 93
Wound-Healing Models p. 94
References p. 95
Gastrointestinal Procedures p. 97
Surgical Anatomy p. 97
General Principles of Abdominal Surgery p. 101
Postoperative Care p. 104
Gastrotomy and Gastrostomy Techniques p. 106
Pyloroplasty p. 108
Enterotomy and Intestinal Fistulation p. 108
Intestinal Infusion Catheter Implantation p. 110
Intestinal Anastomosis p. 112
Intestinal Diversion or Intestinal Bypass p. 113
Colonic Anastomosis and Fistulation p. 115
Total Colectomy p. 116
Rectal Prolapse p. 116
Intestinal and Multivisceral Transplantation p. 117
Vagotomy p. 119
Intraperitoneal Sepsis, Septic Shock, and Hemorrhagic Shock p. 120
References p. 120
Liver and Biliary System p. 123
Surgical Anatomy and General Principles of Surgery p. 123
Cholecystectomy p. 126
Cannulation or Constriction of the Common Bile Duct p. 128
Partial Hepatectomy, Liver Biopsy, and Intrahepatic Cannulation p. 132
Liver Transplantation p. 133
Donor Liver p. 134
Allograft and Autograft Implantation p. 134
Segmental Liver Grafts p. 135
Hepatic Xenoperfusion p. 135
References p. 137
Pancreas and Spleen p. 141
Surgical Anatomy and General Principles of Surgery p. 141
Pancreatectomy, Islet Cell Ablation, and Diabetes p. 141
Segmental Pancreatectomy, Pancreatic Transplant, and Islet Cell Isolation p. 147
Pancreatic Duct Ablation, Cannulation, and Pancreatitis p. 149
Splenectomy, Splenic Vascular Catheterization, and Splenic Transplantation p. 150
References p. 153
Urinary System and Adrenal Glands p. 157
General Principles of Surgery and Surgical Anatomy p. 157
Nephrectomy p. 161
Partial Nephrectomy and Intrarenal Surgery p. 163
Renal Transplant p. 164
Cystotomy and Ureteral Diversion p. 166
Urinary Tract Obstruction, Reflux Nephropathy, and Hydronephrosis p. 167
Perineal Urethrostomy and Urinary Diversion p. 168
Preputial Diverticulum Ablation p. 169
Adrenalectomy p. 172
References p. 172
The Reproductive System p. 175
General Principles of Surgery p. 175
Castration (Orchiectomy) and Vasectomy p. 177
Ovariohysterectomy, Hysterectomy, Ovariectomy, or Tubal Ligation p. 177
Cesarean Section (C-Section) p. 179
Fetal Surgery and Fetal Catheterization p. 180
Prolapse of the Reproductive Tract p. 187
Endometriosis p. 190
Pelvic Adhesions p. 191
Artificial Insemination and Embryo Transfer p. 191
Mammectomy p. 192
References p. 192
Cardiothoracic and Vascular Surgery/Chronic Intravascular Catheterization p. 195
General Principles of Cardiothoracic Surgery and Surgical Anatomy p. 195
Pulmonary System p. 211
Tracheostomy and Tracheotomy p. 211
Pneumonectomy and Lobectomy p. 212
Pulmonary Transplant p. 214
Cardiovascular System p. 214
Peripheral Vascular Cannulation and Chronic Catheterization Techniques p. 214
General Principles p. 214
General Surgical Principles for Catheterization p. 215
Catheter Design p. 218
Catheter Maintenance p. 220
Neck Vessels: External and Internal Jugular Veins and Carotid Artery p. 221
Leg Vessels p. 227
Portal Vein p. 228
Other Blood Vessels p. 231
Postoperative Considerations p. 231
Vascular Anastomosis p. 231
Arteriovenous and Venovenous Fistulas and Vascular Shunts p. 234
Atriotomy and Ventriculotomy p. 235
Valvular Surgery p. 236
Aortic and Pulmonary Artery Banding, Ligation of the Ductus Arteriosus, and Chronic Instrumentation p. 238
Myocardial Infarction and Associated Arrhythmias p. 240
Vascular Aneurysms p. 243
Bifurcation Aneurysms p. 243
Terminal Aneurysms p. 244
Fusiform Aneurysms p. 244
Wide-Necked Aneurysms p. 244
Coarctation of the Aorta p. 245
Cardiomyoplasty p. 246
Epicardial Pacemaker and Device Implantation p. 247
Heart and Heart-Lung Transplantation p. 249
Heart Transplant p. 249
Donor p. 249
Recipient p. 249
Heart-Lung Transplant p. 250
Miscellaneous Thoracic Procedures p. 250
Thoracic Duct Cannulation p. 250
Esophageal Surgery p. 251
References p. 252
Head and Neck Surgery/Central Nervous System p. 261
General Principles of Surgery and Surgical Anatomy p. 261
Dental Procedures and Tusk Trimming p. 272
Maxillofacial and Craniotomy Procedures p. 274
Ocular Surgery p. 275
Pharyngostomy Tubes p. 278
Thyroidectomy p. 278
Parathyroidectomy p. 278
Hypophysectomy p. 279
Spinal Cord Ischemia and Hemorrhage p. 280
Stroke Models p. 281
Cerebrospinal Fluid (CSF) Collection and Epidural Injection p. 281
Epidural Injection p. 282
CSF Collection p. 283
References p. 284
Musculoskeletal System and Orthopedic Procedures p. 289
General Principles of Surgery and Surgical Anatomy p. 289
Amputation of a Digit and Hoof Trimming p. 290
Tendon and Ligament Repair p. 291
Tail Amputation p. 292
Hernia Repair p. 292
Surgical Approaches to Bones and Joints p. 293
Foreleg p. 294
Hind Limb p. 294
Vertebral Column p. 295
Bone Marrow Aspiration p. 295
References p. 297
Cardiovascular Catheterization, Electrophysiology, and Imaging Laboratory Procedures p. 299
Introduction p. 299
Peripheral Vascular Access for Cardiovascular Catheters p. 299
Anesthetics and Adjunct Drugs p. 304
Hemodynamics p. 305
Angioplasty Balloon Techniques, Intravascular Device Implantations, and Restenosis p. 307
Atherosclerosis p. 314
Electrophysiology and Electrocardiography (ECG) and Telemetry p. 316
Pacemaker Implantation and Endocardial Pacemaker Leads p. 324
Conduction System Ablation p. 328
Angiography p. 329
Echocardiography p. 334
References p. 340
Endoscopic, Laparoscopic, and Minimally Invasive Surgery p. 345
Introduction p. 345
General Considerations p. 345
Anatomic Considerations for Flexible Endoscopic Research p. 345
Performing Endoscopy p. 346
Endoscopic Retrograde Cholangiopancreatography (ERCP) p. 349
Endoscopic Hemostasis (Gastrointestinal Bleeding) p. 350
Colonoscopy p. 351
Laryngoscopy and Bronchoscopy p. 351
Training in Flexible Endoscopy p. 351
Laparoscopic, Celioscopic, and Thoracoscopic Surgery p. 353
Cholecystectomy p. 354
Small Intestinal Anastomosis p. 354
Colonic Anastomosis p. 355
Vagotomy and Hiatal Procedures p. 355
Nephrectomy and Renal Ablation p. 356
Inguinal Herniorrhaphy p. 356
Appendectomy p. 357
Splenectomy p. 357
Adrenalectomy p. 357
Urinary Bladder Procedures p. 357
Reproductive Procedures p. 357
Thoracoscopy p. 357
Laparoscopic Ultrasonography p. 358
Postoperative Care for Laparoscopic and Endoscopic Procedures p. 358
Natural Orifice Transluminal Endoscopic Surgery (NOTES) p. 358
Surgical Robotics p. 359
References p. 360
Xenotransplantation and Transgenic Technologies p. 365
Introduction p. 365
Ethical Considerations p. 365
Immunologic and Physiological Considerations p. 366
Strategies for Development of Transgenic Animals p. 367
Regulatory Guidelines p. 367
Public Health Considerations p. 368
Management and Husbandry Strategies p. 369
Other Considerations p. 369
References p. 370
Toxicology p. 373
Introduction p. 373
Domestic Pigs and Minipigs p. 373
Strains of Minipigs p. 373
Pharmacokinetics and Metabolism p. 374
Repeat Dose Toxicology p. 374
Routes of Dose Administration p. 375
Observations and Sampling Techniques p. 375
Necropsy Procedure p. 375
Histopathology p. 376
Reproductive Toxicology p. 377
Juvenile Studies p. 377
Regulatory Acceptance p. 379
Conclusions for Toxicological Models p. 379
Acknowledgments p. 379
References p. 380
Radiobiology p. 383
References p. 384
Imaging Techniques: CT, MRI, and PET Scanning p. 387
Scanners p. 387
Anesthesia p. 387
Surgery p. 388
Monitoring p. 388
Scanning Procedures p. 389
Technical Information for Each of the Images on the Attached DVD p. 389
Instructions for Opening the DVD p. 389
Contrast Radiograph of the Cerebral Artery p. 390
MRI (Magnetic Resonance Imaging) p. 391
PET (Positron Emission Tomography) p. 392
Dopamine Receptors p. 393
PET Scan of a 40-kg Female Pig after Injection of [superscript 18]F Galactose p. 394
CT and PET/CT of a Domestic Pig p. 395
Ossabaw Island Miniature Swine: Cardiometabolic Syndrome Assessment p. 397
Introduction p. 397
Characterization of the Model p. 398
Summary and Conclusions p. 399
Acknowledgments p. 400
References p. 400
Appendix p. 403
Growth Charts, Nutrition, and Physiological Parameters p. 405
Hematology and Serum Chemistry p. 409
Organ Weights and Measurements p. 430
Reproductive Parameters p. 436
Fetal Parameters p. 439
Section 6: Animal Health and General References p. 446
General Reference Textbooks for Swine p. 449
Review Articles p. 449
Web Sites p. 450
Index p. 451
Swine in the laboratory : surgery, anesthesia, imaging, and experimental techniques / 2nd ed.
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