简介
Brain Slices in Basic and Clinical Research describes advancements in the field of brain function and dysfunction through use of central nervous system slice preparations. Topics are authored by leading scientists and include the following:
Mechanisms of synaptic plasticity as the basis of memory processes
Chaos and synaptic variability
Brain calcium currents
Glutamate receptors
Pathophysiology of excitotoxins
Cerebral hypoxia-ischemia
Neuronal injury
Free radicals
Optical methods of measuring brain metabolism
Voltammetry in brain slices
Calcium imaging
Patch-clamp recording and application of macromolecules through patch-clamp pipettes in brain slices
Intracellular double labeling of various neuronal populations
Use of brain slices in teaching neurophysiological methods
Most of the topics are published in book format for the first time, and some of the techniques are more fully detailed than in any other book.
目录
1. Advances in Understanding the Mechanisms Underlying Synaptic Plasticity / Timothy J. Teyler, Idil Cavus, Chris Coussens, Pascal DiScenna, Lawrence Grover, Yi-Ping Lee and Zeb Little
2. Chaotic Components of Synaptic Variability in Hippocampal Pathways / Peter G. Aitken, Steven J. Schiff and Tim Sauer
3. Intrinsic Optical Properties of Brain Slices: Useful Indices of Electrophysiology and Metabolism / Thomas J. Sick and Joseph C. LaManna
4. Voltammetry in Brain Slices / Jonathan A. Stamford
5. Imaging of Intracellular Calcium in Hippocampal Slices: Methods, Limitations, and Achievements / Menahem Segal and Jonathan Auerbach
6. Patch-Clamp Recording in Brain Slices / Frances A. Edwards
7. Intracellular Application of Macromolecules Through Patch Pipettes in Brain Slices / Meenakshi Alreja and George K. Aghajanian
8. Intracellular Double Labeling of Substantia Nigra and Pedunculopontine Neurons in In Vitro Slice Preparation / Steve T. Kitai and Y. Kuga
9. The Importance of Temperature Control When Investigating High-Threshold Calcium Currents in Mammalian Neurones / R. Hamish McAllister-Williams and John S. Kelly
10. A Neurochemical Approach to Elucidate Metabotropic vs. Ionotropic Glutamate Receptor Activities in Rat Hippocampal Slices / Darryle D. Schoepp and Manisha A. Desai
11. Radiotracer Labeling of Brain Slices / George C. Newman, Frank E. Hospod, Clifford S. Patlak and Hui Qi
12. The Pharmacology of Excitotoxins and Energy Deprivation in Hippocampal Slices / Avital Schurr and Benjamin M. Rigor
13. Delayed Neuronal Injury in the Hippocampal Slice / Roi Ann Wallis and Kimberly L. Panizzon
14. Gene Expression as an Index of Pathophysiology Associated with Slice Preparation / Thaddeus S. Nowak, Jr., Qihong Zhou, Pamela J. Voulalas and John M. Sarvey
15. Studies on Anoxic Depolarization / Maurizio Balestrino
16. The Use of Brain Slices in the Study of Free Radical Actions / Terry C. Pellmar
17. Using the In Vitro Hippocampal,-
2. Chaotic Components of Synaptic Variability in Hippocampal Pathways / Peter G. Aitken, Steven J. Schiff and Tim Sauer
3. Intrinsic Optical Properties of Brain Slices: Useful Indices of Electrophysiology and Metabolism / Thomas J. Sick and Joseph C. LaManna
4. Voltammetry in Brain Slices / Jonathan A. Stamford
5. Imaging of Intracellular Calcium in Hippocampal Slices: Methods, Limitations, and Achievements / Menahem Segal and Jonathan Auerbach
6. Patch-Clamp Recording in Brain Slices / Frances A. Edwards
7. Intracellular Application of Macromolecules Through Patch Pipettes in Brain Slices / Meenakshi Alreja and George K. Aghajanian
8. Intracellular Double Labeling of Substantia Nigra and Pedunculopontine Neurons in In Vitro Slice Preparation / Steve T. Kitai and Y. Kuga
9. The Importance of Temperature Control When Investigating High-Threshold Calcium Currents in Mammalian Neurones / R. Hamish McAllister-Williams and John S. Kelly
10. A Neurochemical Approach to Elucidate Metabotropic vs. Ionotropic Glutamate Receptor Activities in Rat Hippocampal Slices / Darryle D. Schoepp and Manisha A. Desai
11. Radiotracer Labeling of Brain Slices / George C. Newman, Frank E. Hospod, Clifford S. Patlak and Hui Qi
12. The Pharmacology of Excitotoxins and Energy Deprivation in Hippocampal Slices / Avital Schurr and Benjamin M. Rigor
13. Delayed Neuronal Injury in the Hippocampal Slice / Roi Ann Wallis and Kimberly L. Panizzon
14. Gene Expression as an Index of Pathophysiology Associated with Slice Preparation / Thaddeus S. Nowak, Jr., Qihong Zhou, Pamela J. Voulalas and John M. Sarvey
15. Studies on Anoxic Depolarization / Maurizio Balestrino
16. The Use of Brain Slices in the Study of Free Radical Actions / Terry C. Pellmar
17. Using the In Vitro Hippocampal,-
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