简介
In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor. "In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology." David E. Clapham, MD, PhD Professor of Neurobiology and Pediatrics Harvard Medical School Dr. Xander H.T. Wehrens received his M.D. and Ph.D. degrees from Maastricht University in the Netherlands. His research has mainly concentrated on molecular mechanisms of cardiac arrhythmias, in particular in the setting of inherited arrhythmogenic syndromes and congestive heart failure. This work has led to the development of novel anti-arrhythmic therapies. He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University. Dr. Andrew R. Marks is the Chair and Professor of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons. Dr. Marks' research has focused on understanding how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems, and on the regulation of vascular smooth muscle proliferation and migration. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction that have lead to the discovery of molecular defects that contribute to heart failure and fatal cardiac arrhythmias.
目录
Dedication 5
Contents 6
Contributing Authors 9
Preface 13
Foreword 16
Chapter 1 EVOLUTION OF THE RYANODINE RECEPTOR GENE FAMILY 19
Chapter 2 TOPOLOGY AND TRANSMEMBRANE ORGANIZATION OF RYANODINE RECEPTORS 27
Chapter 3 THREE- DIMENSIONAL RECONSTRUCTION OF RYANODINE RECEPTORS 42
Chapter 4 RYR- DHPR RELATIONSHIPS IN SKELETAL AND CARDIAC MUSCLES 52
Chapter 5 THE PORE OF THE RYANODINE RECEPTOR CHANNEL 59
Chapter 6 INTRA- MOLECULAR DOMAIN-DOMAIN INTERACTION 69
Chapter 7 REGULATION OF SARCOPLASMIC RETICULUM CALCIUM RELEASE BY LUMINAL CALCIUM 82
Chapter 8 CYTOSOLIC CALCIUM REGULATION OF SINGLE RYANODINE RECEPTOR CHANNELS 92
Chapter 9 ELEMENTARY RELEASE EVENTS: RYANODINE RECEPTOR SPARKS 102
Chapter 10 RELEASE FROM THE SARCOPLASMIC RETICULUM IN INTACT CARDIOMYOCYTES 113
Chapter 11 STABILITY AND INSTABILITY OF RELEASE FROM THE SR 124
Chapter 12 RYANODINE RECEPTORS IN SMOOTH MUSCLE 133
Chapter 13 FUNCTIONS OF RYR3 HOMOLOGUES 143
Chapter 14 KNOCKOUT MICE LACKING RYR AND JUNCTOPHILIN SUBTYPES 153
Chapter 15 REGULATION OF RYANODINE RECEPTOR RELEASE BY MACROMOLECULAR COMPLEXES 163
Chapter 16 RYR1 MODULATION BY CALMODULIN 174
Chapter 17 RYANODINE RECEPTOR FUNCTION IN INFLAMMATION 180
Chapter 18 RYANOIDS, RECEPTOR AFFINITY AND RYR CHANNEL SUBCONDUCTANCE 190
Chapter 19 SCORPION PEPTIDES AS HIGH-AFFINITY PROBES OF RYANODINE RECEPTOR FUNCTION 201
Chapter 20 REDOX SENSING BY THE RYANODINE RECEPTORS 211
Chapter 21 RYANODINE RECEPTOR DYSFUNCTION IN THE DIABETIC HEART 219
Chapter 22 MOLECULAR AND CLINICAL GENETICS OF RYR1 DISORDERS 229
Chapter 23 PATHOPHYSIOLOGY OF MUSCLE DISORDERS LINKED TO MUTATIONS IN THE SKELETAL MUSCLE RYANODINE RECEPTOR 238
Chapter 24 THE DANTROLENE BINDING SITE ON RYR1 252
Chapter 25 RYANODINE RECEPTOR DYSFUNCTION IN HEART FAILURE AND ARRHYTHMIAS 261
Chapter 26 STABILIZATION OF RYANODINE RECEPTOR AS A NOVEL THERAPEUTIC STRATEGY AGAINST HEART FAILURE 270
Chapter 27 RYANODINE RECEPTOR ANTIBODIES AND MYASTHENIA GRAVIS 280
References 287
INDEX 318
Contents 6
Contributing Authors 9
Preface 13
Foreword 16
Chapter 1 EVOLUTION OF THE RYANODINE RECEPTOR GENE FAMILY 19
Chapter 2 TOPOLOGY AND TRANSMEMBRANE ORGANIZATION OF RYANODINE RECEPTORS 27
Chapter 3 THREE- DIMENSIONAL RECONSTRUCTION OF RYANODINE RECEPTORS 42
Chapter 4 RYR- DHPR RELATIONSHIPS IN SKELETAL AND CARDIAC MUSCLES 52
Chapter 5 THE PORE OF THE RYANODINE RECEPTOR CHANNEL 59
Chapter 6 INTRA- MOLECULAR DOMAIN-DOMAIN INTERACTION 69
Chapter 7 REGULATION OF SARCOPLASMIC RETICULUM CALCIUM RELEASE BY LUMINAL CALCIUM 82
Chapter 8 CYTOSOLIC CALCIUM REGULATION OF SINGLE RYANODINE RECEPTOR CHANNELS 92
Chapter 9 ELEMENTARY RELEASE EVENTS: RYANODINE RECEPTOR SPARKS 102
Chapter 10 RELEASE FROM THE SARCOPLASMIC RETICULUM IN INTACT CARDIOMYOCYTES 113
Chapter 11 STABILITY AND INSTABILITY OF RELEASE FROM THE SR 124
Chapter 12 RYANODINE RECEPTORS IN SMOOTH MUSCLE 133
Chapter 13 FUNCTIONS OF RYR3 HOMOLOGUES 143
Chapter 14 KNOCKOUT MICE LACKING RYR AND JUNCTOPHILIN SUBTYPES 153
Chapter 15 REGULATION OF RYANODINE RECEPTOR RELEASE BY MACROMOLECULAR COMPLEXES 163
Chapter 16 RYR1 MODULATION BY CALMODULIN 174
Chapter 17 RYANODINE RECEPTOR FUNCTION IN INFLAMMATION 180
Chapter 18 RYANOIDS, RECEPTOR AFFINITY AND RYR CHANNEL SUBCONDUCTANCE 190
Chapter 19 SCORPION PEPTIDES AS HIGH-AFFINITY PROBES OF RYANODINE RECEPTOR FUNCTION 201
Chapter 20 REDOX SENSING BY THE RYANODINE RECEPTORS 211
Chapter 21 RYANODINE RECEPTOR DYSFUNCTION IN THE DIABETIC HEART 219
Chapter 22 MOLECULAR AND CLINICAL GENETICS OF RYR1 DISORDERS 229
Chapter 23 PATHOPHYSIOLOGY OF MUSCLE DISORDERS LINKED TO MUTATIONS IN THE SKELETAL MUSCLE RYANODINE RECEPTOR 238
Chapter 24 THE DANTROLENE BINDING SITE ON RYR1 252
Chapter 25 RYANODINE RECEPTOR DYSFUNCTION IN HEART FAILURE AND ARRHYTHMIAS 261
Chapter 26 STABILIZATION OF RYANODINE RECEPTOR AS A NOVEL THERAPEUTIC STRATEGY AGAINST HEART FAILURE 270
Chapter 27 RYANODINE RECEPTOR ANTIBODIES AND MYASTHENIA GRAVIS 280
References 287
INDEX 318
- 名称
- 类型
- 大小
光盘服务联系方式: 020-38250260 客服QQ：4006604884
云图客服：
用户发送的提问，这种方式就需要有位在线客服来回答用户的问题，这种 就属于对话式的,问题是这种提问是否需要用户登录才能提问
Video Player
×
Audio Player
×
pdf Player
×
