简介
表观遗传学是研究非DNA序列变化的、可遗传的表达改变的科学,表观遗 传学机制参与个体发育、成体的许多生物学进程中基因表达的调节,这一过程的 异常可导致人类癌症和其他疾病的发生。本书是基础研究专著,24章均由知名 专家撰写,分别从不同角度探讨表观遗传学问题。首先介绍表观遗传学简史、基 本概念;然后详细阐释表观遗传调节的分子机制及与之相关的细胞生物学过程; 介绍了组氨酸和DNA甲基化,siRNA和基因沉默,x染色体失活,剂量补偿和 印记,以及微生物、植物、昆虫和哺乳动物中的表观遗传机制;还讨论了细胞分裂 和分化中的表观遗传作用,以及这些途径中发生的错误对癌症和人类肿瘤的影 响;此外,也阐述了表观遗传在动物克隆中可能发生的影响。 更多>>
目录
preface
1 epigenetics: from phenomenon to field
2 a brief history of epigenetics
3 overview and concepts
4 epigenetics in saccharomyces cerevisiae
5 position-effect variegation, heterochromatin formation, and gene silencing in drosophila
6 fungal models for epigenetic research: schizosac charomyces pombe and neurospora crassa
7 epigenetics of ciliates
8 rnai and heterochromatin assembly
9 epigenetic regulation in plants
10 chromatin modifications and their mechanism of action
11 transcriptional silencing by polycomb group proteins
12 transcriptional regulation by trithorax group proteins
13 histone variants and epigenetics
14 epigenetic regulation of chromosome inheritance
15 epigenetic regulation of the x chromosomes in c. elegans
16 dosage compensation in drosophila
17 dosage compensation in mammals
18 dna methylation in mammals
19 genomic imprinting in mammals
.20 germ line and pluripotent stem cells
21 epigenetic control of lymphopoiesis
22 nuclear transplantation and the reprogramming of the genome
23 epigenetics and human disease
24 epigenetic determinants of cancer
appendices
1 www resources
2 histone modifications and references
index
1 epigenetics: from phenomenon to field
2 a brief history of epigenetics
3 overview and concepts
4 epigenetics in saccharomyces cerevisiae
5 position-effect variegation, heterochromatin formation, and gene silencing in drosophila
6 fungal models for epigenetic research: schizosac charomyces pombe and neurospora crassa
7 epigenetics of ciliates
8 rnai and heterochromatin assembly
9 epigenetic regulation in plants
10 chromatin modifications and their mechanism of action
11 transcriptional silencing by polycomb group proteins
12 transcriptional regulation by trithorax group proteins
13 histone variants and epigenetics
14 epigenetic regulation of chromosome inheritance
15 epigenetic regulation of the x chromosomes in c. elegans
16 dosage compensation in drosophila
17 dosage compensation in mammals
18 dna methylation in mammals
19 genomic imprinting in mammals
.20 germ line and pluripotent stem cells
21 epigenetic control of lymphopoiesis
22 nuclear transplantation and the reprogramming of the genome
23 epigenetics and human disease
24 epigenetic determinants of cancer
appendices
1 www resources
2 histone modifications and references
index
表观遗传学
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