简介
Summary:
Publisher Summary 1
Researchers explain the technology behind the highly touted Human Genome Project, and especially the technological innovations it has drawn from and contributed to. Considering informatics, robotics, optical and microfabrication techniques, and information management systems, they offer first-hand case studies of automation and control systems and workable models for standardized hardware and software interfaces. They also explore emerging technologies such as capillary gel electrophoresis, miniaturization, and mass spectrometry. Tutorials throughout clarify biological issues underlying the technology. Accessible to non-specialists. Annotation c. by Book News, Inc., Portland, Or.
Publisher Summary 2
An accessible overview of the latest advancements in automation technologies for genetic mapping—a blueprint for the laboratory of the futur Although much has been written about the genetic science at work in the Human Genome Project, to date there has been a serious gap in the literature about the technology that propels the project. Bringing together a group of leading researchers, this work presents a unified vision of the vital role played by technological innovation in tackling the tremendous challenges of genome characterization. Areas covered include informatics, robotics, optical and microfabrication techniques, and information management systems. Accessible to geneticists and nongeneticists alike, this clearly written resource provides: Illuminating, firsthand case studies of laboratory automation and control systems at highly successful facilities, including workable models for standardized hardware and software interfaces Examinations of promising emergent technologies in such areas as capillary gel electrophoresis, miniaturization, and mass spectrometry Practical discussions of computer simulation and information management for use in the creation of efficient genome factories Tutorials throughout to clarify biological issues underlying each technologyAs one of the first books to address the spectrum of technologies that will carry genetic research into the next millennium, Automation Technologies for Genome Characterization is an indispensable reference for genome researchers as well as biologists, engineers, and computer scientists working in this exciting field Wiley-Interscience Series on Laboratory Automatio
目录
Table Of Contents:
PREFACE xi
PART I LABORATORY AUTOMATION 1(106)
1 CUSTOM HARDWARE AND SOFTWARE FOR GENOME CENTER OPERATIONS: FROM ROBOTIC CONTROL TO DATABASES 3(40)
H. R. (Skip) Garner
2 AUTOMATION STRATEGIES: A MODULAR APPROACH 43(22)
Martin J. Pollard
3 LARGE-SCALE LIBRARY CHARACTERIZATION 65(24)
Elmar Maier
David R. Bancroft
Hans Lehrach
4 MACHINE VISION AND VISION-GUIDED MOTION FOR GENOME AUTOMATION 89(18)
Sarath Krishnaswamy
John E. Agapakis
PART II CONTROL SYSTEMS 107(36)
5 A SCRIPT-DIRECTED CONTROLLER OF MODULAR AUTOMATION (SDCMA) FOR GENOME LABORATORIES 109(16)
Bobi Den Hartog
Patricia A. Medvick
6 GUILE: A LABORATORY AUTOMATION SOFTWARE FRAMEWORK 125(18)
Scott P. Hunicke-Smith
PART III ADVANCED TOPICS 143(112)
7 CAPILLARY GEL ELECTROPHORESIS FOR LARGE-SCALE DNA SEQUENCING: SEPARATION AND DETECTION 145(22)
Norman J. Dovichi
8 SCANNING PROBE MICROSCOPY IN GENOMIC RESEARCH 167(22)
Dave P. Allison
Thomas G. Thundat
Robert J. Warmack
9 A MINIATURE INTEGRATED NUCLEIC ACID ANALYSIS SYSTEM 189(16)
M. Allen Northrup
Bart Beeman
Bill Benett
Dean Hadley
Phoebe Landre
Stacy Lehew
10 GENOSENSORS AND MODEL HYBRIDIZATION STUDIES 205(22)
Mitchel J. Doktycz
Kenneth L. Beattie
11 MASS SPECTROMETRIC METHODS IN DNA CHARACTERIZATION 227(28)
Peter Williams
Chau-Wen Chou
David M. Schieltz
PART IV ANALYSIS AND SYNTHESIS 255(40)
12 PETRI NET MODELING AND SIMULATION FOR AUTOMATED SYSTEMS 257(22)
Deirdre Meldrum
Emerson Tongco
13 INTEGRATING DATA ACQUISITION, ANALYSIS, AND MANAGEMENT 279(16)
Chris Fields
INDEX 295
PREFACE xi
PART I LABORATORY AUTOMATION 1(106)
1 CUSTOM HARDWARE AND SOFTWARE FOR GENOME CENTER OPERATIONS: FROM ROBOTIC CONTROL TO DATABASES 3(40)
H. R. (Skip) Garner
2 AUTOMATION STRATEGIES: A MODULAR APPROACH 43(22)
Martin J. Pollard
3 LARGE-SCALE LIBRARY CHARACTERIZATION 65(24)
Elmar Maier
David R. Bancroft
Hans Lehrach
4 MACHINE VISION AND VISION-GUIDED MOTION FOR GENOME AUTOMATION 89(18)
Sarath Krishnaswamy
John E. Agapakis
PART II CONTROL SYSTEMS 107(36)
5 A SCRIPT-DIRECTED CONTROLLER OF MODULAR AUTOMATION (SDCMA) FOR GENOME LABORATORIES 109(16)
Bobi Den Hartog
Patricia A. Medvick
6 GUILE: A LABORATORY AUTOMATION SOFTWARE FRAMEWORK 125(18)
Scott P. Hunicke-Smith
PART III ADVANCED TOPICS 143(112)
7 CAPILLARY GEL ELECTROPHORESIS FOR LARGE-SCALE DNA SEQUENCING: SEPARATION AND DETECTION 145(22)
Norman J. Dovichi
8 SCANNING PROBE MICROSCOPY IN GENOMIC RESEARCH 167(22)
Dave P. Allison
Thomas G. Thundat
Robert J. Warmack
9 A MINIATURE INTEGRATED NUCLEIC ACID ANALYSIS SYSTEM 189(16)
M. Allen Northrup
Bart Beeman
Bill Benett
Dean Hadley
Phoebe Landre
Stacy Lehew
10 GENOSENSORS AND MODEL HYBRIDIZATION STUDIES 205(22)
Mitchel J. Doktycz
Kenneth L. Beattie
11 MASS SPECTROMETRIC METHODS IN DNA CHARACTERIZATION 227(28)
Peter Williams
Chau-Wen Chou
David M. Schieltz
PART IV ANALYSIS AND SYNTHESIS 255(40)
12 PETRI NET MODELING AND SIMULATION FOR AUTOMATED SYSTEMS 257(22)
Deirdre Meldrum
Emerson Tongco
13 INTEGRATING DATA ACQUISITION, ANALYSIS, AND MANAGEMENT 279(16)
Chris Fields
INDEX 295
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