Agrochemical discovery : insect, weed, and fungal control /
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作 者:Don R. Baker, editor,Noriharu Ken Umetsu, editor.
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ISBN:9780841237247
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简介
Based on an October 1999 conference held on Honolulu, this volume looks at the process of discovery in the field of crop protection. The 24 papers explore natural products, agricultural biotechnology, the combinatorial chemistry approach for synthesizing large numbers of compounds, and mode of action studies for the development of new insect control agents. Topics include fungicidal properties of cyclopropanecarboxamides, bioactive substances from medicinal plants, an integrated management program for clubfoot of cruciferous plants, and a specific inhibitor of brassinosteroid biosynthesis. Distributed by Oxford University Press. Annotation c. Book News, Inc., Portland, OR (booknews.com)
目录
Preface p. ix
1. Modern Agrochemical Discovery Don R. Baker and Noriharu Ken Umetsu p. 1
Synthesis and Chemistry Eiichi Kuwano and Don R. Baker
2. The Synthesis and Structure--Activity Relationships of the Triketone HPPD Herbicides David L. Lee and Christopher G. Knudsen and William J. Michaely and John B. Tarr and Hsiao-Ling Chin and Nhan H. Nguyen and Charles G. Carter and Thomas H. Cromartie and Byron H. Lake|cJohn M. Shribbs and Stott Howard and Sean Hanser and D. Dagarin p. 8
3. Evolution of the Sodium Channel Blocking Insecticides: The Discovery of Indoxacarb George P. Lahm and Stephen F. McCann and Charles R. Harrison and Thomas M. Stevenson and Rafael Shapiro p. 20
4. Synthesis and Fungicidal Properties of Cyclopropanecarboxamides Katsuaki Wada and Gerd Han[beta]ler and Shinzo Kagabu and Udo Kraatz and Yoshio Kurahashi and Haruko Sawada p. 35
Natural Products Hiroshi Abe and Horace G. Cutler
5. Natural Products from New Zealand Plants Nigel B. Perry p. 48
6. Chemistry of Spore Germination Self-Inhibitors from the Plant Pathogenic Fungus Collectotrichum fragariae Hisashi Miyagawa and Masafumi Inoue and Hisaki Yamanaka and Tetsu Tsurushima and Tamio Ueno p. 62
7. Bioherbicides: Phytotoxic Natural Products Robert E. Hoagland p. 72
8. Conjugated and Unconjugated Brassinosteroids Hiroshi Abe and Kazuo Soeno and Naoko-N Koseki and Masahiro Natsume p. 91
9. Bioactive Substances from Medicinal Plants A. Douglas Kinghorn and Leng Chee Chang and Baoliang Cui p. 102
Agricultural Biotechnology Hideo Ohkawa and William P. Ridley
10. Herbicide Resistant Transgenic Plants Expressing Cytochrome P450 Monooxygenases Metabolizing Xenobiotics Hideo Ohkawa and Hideyuki Inui and Yoshiro Imajuku and Hiromasa Imaishi and Yasunobu Ohkawa p. 116
11. Utilizing the Systemic Acquired Resistance Signal Transduction Pathway to Enhance Plant Health Kay A. Lawton and Leslie Friedrich and Rebecca Cade and Michael Willits and Laura Weislo and Robert A. Dietrich and Michael Oostendorp and John Salmeron p. 127
12. Engineering Herbicide Tolerance with Glutathione Transferases R. Edwards and C. J. Andrews and Ian Jepson p. 133
13. Trends in Biocontrol Research on Soilborne Plant Diseases: In Integrated Management Programs on Clubroot Disease of Crucifers Tsutomu Arie and Katsuyoshi Yoneyama and Isamu Yamaguchi p. 142
14. Status and Safety of Biotech Crops James D. Astwood and Roy L. Fuchs p. 152
Combinatorial Chemistry Joseph G. E. Fenyes and Isao Iwataki
15. Similarities in Bioanalogous Structural Transformation Patterns: Application to Virtual Library Design for Combinatorial Syntheses of Bioactive Compounds Toshio Fujita p. 166
16. Preparation of Small Molecule Libraries for Agrochemical Discovery: Development of Parallel Solution and Solid Phase Synthesis Methods Bruce C. Hamper and Thomas J. Owen and Kevin D. Jerome and Angela S. Scates and Stephen A. Kolodziej and Robert C. Chott and Allen S. Kesselring p. 180
17. Parallel Synthesis at Novartis Crop Protection: Concept and Realization M. Diggelmann and J. Ehrler and W. Lutz p. 196
18. The Application of Combinatorial Chemistry in Agrochemical Discovery William A. Kleschick and L. Navelle Davis and Michael R. Dick and Joseph R. Garlich and Eric J. Martin and Nailah Orr and Simon C. Ng and Daniel J. Pernich and Steven H. Unger and Gerald B. Watson and Ronald N. Zuckermann p. 205
19. Combinatorial Chemistry in the Agrochemical Discovery Process at Zeneca Richard D. Gless and Karl J. Fisher and Donald R. James p. 214
20. Biorational Design, Synthesis and Inhibition of Photosystem II Inhibitors Huayin Liu and Yinlin Sha and Aiming Yu and Huifen Tan and Huazheng Yang p. 226
Mode of Action Studies Keiichiro Nishimura and Don R. Baker
21. New Insecticides: Modes of Action and Selective Toxicity Robert M. Hollingworth p. 238
22. Molecular Interactions of Non-Competitive Antagonists with Ionotropic [gamma]-Aminobutyric Acid Receptors: Studies into Species Difference Yoshihisa Ozoe and Miki Akamatsu p. 256
23. Mode of Action of Brassinazole: A Specfic Inhibitor of Brassinosteroid Biosynthesis Tadao Asami and Yong Ki Min and Katsuhiko Sekimata and Yukihisa Shimada and Jing Ming Wang and Shozo Fujioka and Shigeo Yoshida p. 269
24. Electrophysiological Studies of Dopamine Release in Murine Striatal Slices and Its Role in the Neurotoxic Action of Cyclodienes Ethan R. Freeborn and Jeffrey R. Bloomquist p. 281
Author Index p. 293
Subject Index p. 295
1. Modern Agrochemical Discovery Don R. Baker and Noriharu Ken Umetsu p. 1
Synthesis and Chemistry Eiichi Kuwano and Don R. Baker
2. The Synthesis and Structure--Activity Relationships of the Triketone HPPD Herbicides David L. Lee and Christopher G. Knudsen and William J. Michaely and John B. Tarr and Hsiao-Ling Chin and Nhan H. Nguyen and Charles G. Carter and Thomas H. Cromartie and Byron H. Lake|cJohn M. Shribbs and Stott Howard and Sean Hanser and D. Dagarin p. 8
3. Evolution of the Sodium Channel Blocking Insecticides: The Discovery of Indoxacarb George P. Lahm and Stephen F. McCann and Charles R. Harrison and Thomas M. Stevenson and Rafael Shapiro p. 20
4. Synthesis and Fungicidal Properties of Cyclopropanecarboxamides Katsuaki Wada and Gerd Han[beta]ler and Shinzo Kagabu and Udo Kraatz and Yoshio Kurahashi and Haruko Sawada p. 35
Natural Products Hiroshi Abe and Horace G. Cutler
5. Natural Products from New Zealand Plants Nigel B. Perry p. 48
6. Chemistry of Spore Germination Self-Inhibitors from the Plant Pathogenic Fungus Collectotrichum fragariae Hisashi Miyagawa and Masafumi Inoue and Hisaki Yamanaka and Tetsu Tsurushima and Tamio Ueno p. 62
7. Bioherbicides: Phytotoxic Natural Products Robert E. Hoagland p. 72
8. Conjugated and Unconjugated Brassinosteroids Hiroshi Abe and Kazuo Soeno and Naoko-N Koseki and Masahiro Natsume p. 91
9. Bioactive Substances from Medicinal Plants A. Douglas Kinghorn and Leng Chee Chang and Baoliang Cui p. 102
Agricultural Biotechnology Hideo Ohkawa and William P. Ridley
10. Herbicide Resistant Transgenic Plants Expressing Cytochrome P450 Monooxygenases Metabolizing Xenobiotics Hideo Ohkawa and Hideyuki Inui and Yoshiro Imajuku and Hiromasa Imaishi and Yasunobu Ohkawa p. 116
11. Utilizing the Systemic Acquired Resistance Signal Transduction Pathway to Enhance Plant Health Kay A. Lawton and Leslie Friedrich and Rebecca Cade and Michael Willits and Laura Weislo and Robert A. Dietrich and Michael Oostendorp and John Salmeron p. 127
12. Engineering Herbicide Tolerance with Glutathione Transferases R. Edwards and C. J. Andrews and Ian Jepson p. 133
13. Trends in Biocontrol Research on Soilborne Plant Diseases: In Integrated Management Programs on Clubroot Disease of Crucifers Tsutomu Arie and Katsuyoshi Yoneyama and Isamu Yamaguchi p. 142
14. Status and Safety of Biotech Crops James D. Astwood and Roy L. Fuchs p. 152
Combinatorial Chemistry Joseph G. E. Fenyes and Isao Iwataki
15. Similarities in Bioanalogous Structural Transformation Patterns: Application to Virtual Library Design for Combinatorial Syntheses of Bioactive Compounds Toshio Fujita p. 166
16. Preparation of Small Molecule Libraries for Agrochemical Discovery: Development of Parallel Solution and Solid Phase Synthesis Methods Bruce C. Hamper and Thomas J. Owen and Kevin D. Jerome and Angela S. Scates and Stephen A. Kolodziej and Robert C. Chott and Allen S. Kesselring p. 180
17. Parallel Synthesis at Novartis Crop Protection: Concept and Realization M. Diggelmann and J. Ehrler and W. Lutz p. 196
18. The Application of Combinatorial Chemistry in Agrochemical Discovery William A. Kleschick and L. Navelle Davis and Michael R. Dick and Joseph R. Garlich and Eric J. Martin and Nailah Orr and Simon C. Ng and Daniel J. Pernich and Steven H. Unger and Gerald B. Watson and Ronald N. Zuckermann p. 205
19. Combinatorial Chemistry in the Agrochemical Discovery Process at Zeneca Richard D. Gless and Karl J. Fisher and Donald R. James p. 214
20. Biorational Design, Synthesis and Inhibition of Photosystem II Inhibitors Huayin Liu and Yinlin Sha and Aiming Yu and Huifen Tan and Huazheng Yang p. 226
Mode of Action Studies Keiichiro Nishimura and Don R. Baker
21. New Insecticides: Modes of Action and Selective Toxicity Robert M. Hollingworth p. 238
22. Molecular Interactions of Non-Competitive Antagonists with Ionotropic [gamma]-Aminobutyric Acid Receptors: Studies into Species Difference Yoshihisa Ozoe and Miki Akamatsu p. 256
23. Mode of Action of Brassinazole: A Specfic Inhibitor of Brassinosteroid Biosynthesis Tadao Asami and Yong Ki Min and Katsuhiko Sekimata and Yukihisa Shimada and Jing Ming Wang and Shozo Fujioka and Shigeo Yoshida p. 269
24. Electrophysiological Studies of Dopamine Release in Murine Striatal Slices and Its Role in the Neurotoxic Action of Cyclodienes Ethan R. Freeborn and Jeffrey R. Bloomquist p. 281
Author Index p. 293
Subject Index p. 295
Agrochemical discovery : insect, weed, and fungal control /
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