Table Of Contents:
SECTION I Introduction to Drug Therapy 1(60)

Introduction to Pharmacology 3(9)

Sources of Drugs 4(1)

Drug Nomenclature 4(1)

Sources of Drug Information 4(1)

Federal Drug Laws and Standards 4(2)

Cellular Physiology 6(1)

Cellular Injury and Response to Injury 7(5)

Basic Concepts and Processes 12(14)

Mechanisms of Drug Movement 13(1)

Pharmacokinetics 13(2)

Pharmacodynamics 15(2)

Variables That Affect Drug Actions 17(3)

Adverse Effects of Drugs 20(4)

Tolerance and Cross-Tolerance 24(2)

Administering Medications 26(15)

Preventing Medication Errors 27(1)

Medication Systems 28(1)

Medication Orders 28(1)

Drug Preparations and Dosage Forms 28(1)

Calculating Drug Dosages 29(1)

Routes of Administration 30(11)

Nursing Process in Drug Therapy 41(20)

Using the Prototype Approach to Study Pharmacology 42(1)

Legal Responsibilities of the Nurse 42(1)

Applying the Nursing Process in Drug Therapy 43(6)

Integrating Nursing Process, Drug Therapy, and Clinical Pathways 49(1)

General Principles of Drug Therapy 50(11)
SECTION II Drugs Affecting the Central Nervous System 61(186)

Physiology of the Central Nervous System 63(8)

Characteristics and Functions of the Central Nervous System 64(5)

Drugs Affecting the Central Nervous System 69(2)

Opioid Analgesics and Opioid Antagonists 71(19)

Pain 72(1)

Endogenous Analgesia System 73(1)

Opioid Analgesics 73(1)

Classifications and Individual Drugs 74(6)

Principles of Therapy 80(10)

Analgesic-Antipyretic-Anti-inflammatory and Related Drugs 90(20)

Description 91(1)

Pain, Fever, and Inflammation 91(1)

Gout 91(1)

Migraine 91(1)

Mechanism of Action 92(1)

Indications For Use 93(1)

Contraindications to Use 93(1)

Individual Drugs 93(7)

Principles of Therapy 100(10)

Antianxiety and Sedative-Hypnotic Drugs 110(19)

Anxiety 111(1)

Sleep and Insomnia 111(1)

Drugs Used to Treat Anxiety and Insomnia 112(8)

Principles of Therapy 120(9)

Antipsychotic Drugs 129(21)

Psychosis 130(1)

Schizophrenia 130(1)

Antipsychotic Drugs 131(1)

Individual Antipsychotic Drugs 132(7)

Principles of Therapy 139(11)

Antidepressants 150(19)

Depression 151(1)

Antidepressant Drugs 152(3)

Individual Antidepressants 155(4)

Principles of Therapy 159(10)

Antiseizure Drugs 169(17)

Seizure Disorders 170(1)

Antiseizure Drugs 170(1)

Individual Antiseizure Drugs 171(6)

Principles of Therapy 177(9)

Antiparkinson Drugs 186(13)

Parkinson's Disease 187(1)

Antiparkinson Drugs 187(1)

Individual Antiparkinson Drugs 188(4)

Principles of Therapy 192(7)

Skeletal Muscle Relaxants 199(6)

Skeletal Muscle Relaxants 200(2)

Principles of Therapy 202(3)

Anesthetics 205(18)

General Anesthesia 206(1)

Regional Anesthesia 206(1)

Adjuncts to Anesthesia 207(1)

Individual Anesthetic Agents 208(6)

Principles of Therapy 214(9)

Substance Abuse Disorders 223(16)

Substance Abuse 224(1)

Dependence 224(1)

Central Nervous System Depressants 225(5)

Central Nervous System Stimulants 230(3)

Marijuana 233(1)

Hallucinogens 234(1)

Volatile Solvents (Inhalants) 234(2)

Principles of Therapy 236(3)

Central Nervous System Stimulants 239(8)

Uses 240(1)

Types of Stimulants 240(1)

Individual Central Nervous System Stimulants 240(2)

Principles of Therapy 242(5)
SECTION III Drugs Affecting the Autonomic Nervous System 247(60)

Physiology of the Autonomic Nervous System 249(7)

Autonomic Nervous System 250(4)

Characteristics of Autonomic Drugs 254(2)

Adrenergic Drugs 256(14)

Description 257(1)

Individual Adrenergic Drugs 258(5)

Principles of Therapy 263(7)

Antiadrenergic Drugs 270(16)

Description 271(2)

Individual Antiadrenergic Drugs 273(5)

Principles of Therapy 278(8)

Cholinergic Drugs 286(9)

Description 287(1)

Individual Cholinergic Drugs 287(3)

Principles of Therapy 290(5)

Anticholinergic Drugs 295(12)

Description 296(2)

Individual Anticholinergic Drugs 298(3)

Principles of Therapy 301(6)
SECTION IV Drugs Affecting the Endocrine System 307(122)

Physiology of the Endocrine System 309(5)

The Endocrine System 310(1)

Endocrine System-Nervous System Interactions 310(1)

General Characteristics of Hormones 311(2)

General Characteristics of Hormonal Drugs 313(1)

Hypothalamic and Pituitary Hormones 314(9)

Description 315(1)

Therapeutic Limitations 316(1)

Individual Hormonal Agents 316(3)

Principles of Therapy 319(4)

Corticosteroids 323(23)

Endogenous Corticosteroids 324(3)

Exogenous Corticosteroids (Glucocorticoid Drugs) 327(9)

Principles of Therapy 336(10)

Thyroid and Antithyroid Drugs 346(13)

Description and Uses 347(1)

Thyroid Disorders 347(2)

Individual Drugs 349(4)

Principles of Therapy 353(6)

Hormones That Regulate Calcium and Bone Metabolism 359(18)

Overview 360(3)

Drugs Used For Calcium and Bone Disorders 363(7)

Principles of Therapy 370(7)

Antidiabetic Drugs 377(30)

Endogenous Insulin 378(2)

Diabetes Mellitus 380(2)

Hypoglycemic Drugs 382(10)

Principles of Therapy 392(15)

Estrogens, Progestins, and Oral Contraceptives 407(15)

Estrogens 408(1)

Progesterone 408(1)

Estrogens and Progestins Used as Drugs 409(2)

Individual Estrogens, Progestins, and Oral Contraceptives 411(3)

Principles of Therapy 414(8)

Androgens and Anabolic Steroids 422(7)

Androgens 423(1)

Anabolic Steroids 423(1)

Testosterone 423(1)

Abuse of Androgenic and Anabolic Steroid Drugs 423(1)

Characteristics of Androgenic and Anabolic Steroid Drugs 423(3)

Principles of Therapy 426(3)
SECTION V Nutrients, Fluids, and Electrolytes 429(62)

Nutritional Support Products and Drugs for Obesity 431(20)

Overview 432(1)

Nutritional Deficiency States 432(1)

Nutritional Products 432(1)

Pancreatic Enzymes 433(3)

Obesity 436(4)

Principles of Therapy 440(11)

Vitamins 451(17)

Overview 452(1)

Description and Uses 452(3)

Vitamin Supplements 455(6)

Principles of Therapy 461(7)

Minerals and Electrolytes 468(23)

Description and Uses 469(2)

Individual Agents Used in Mineral-Electrolyte and Acid-Base Imbalances 471(9)

Principles of Therapy 480(11)
SECTION VI Drugs Used to Treat Infections 491(138)

General Characteristics of Antimicrobial Drugs 493(19)

Microorganisms and Infections 494(6)

Host Defense Mechanisms 500(1)

Characteristics of Anti-Infective Drugs 501(3)

Principles of Therapy 504(8)

Beta-Lactam Antibacterials: Penicillins, Cephalosporins, and Others 512(17)

Description 513(1)

Penicillins 513(5)

Cephalosporins 518(1)

Carbapenems 519(1)

Monobactam 520(1)

Principles of Therapy 520(9)

Aminoglycosides and Fluoroquinolones 529(12)

Aminoglycosides 530(3)

Fluoroquinolones 533(1)

Principles of Therapy 534(7)

Tetracyclines, Sulfonamides, and Urinary Agents 541(13)

Description 542(7)

Principles of Therapy 549(5)

Macrolides and Miscellaneous Antibacterials 554(11)

Macrolides 555(1)

Miscellaneous Antibacterial Drugs 555(4)

Principles of Therapy 559(6)

Drugs for Tuberculosis and Mycobacterium Avium Complex (MAC) Disease 565(13)

Tuberculosis 566(1)

Multidrug-Resistant Tuberculosis 566(1)

Chemoprophylaxis of Tuberculosis 566(1)

Treatment of Tuberculosis 566(1)

Characteristics of Antitubercular Drugs 567(1)

Individual Antitubercular Drugs 568(2)

Mycobacterium Avium Complex Disease 570(2)

Principles of Therapy 572(6)

Antiviral Drugs 578(22)

General Characteristics of Viruses and Viral Infections 579(11)

Principles of Therapy 590(10)

Antifungal Drugs 600(14)

Fungi and Fungal Infections 601(2)

Antifungal Drugs 603(3)

Principles of Therapy 606(8)

Antiparasitics 614(15)

Protozoal Infections 615(1)

Helminthiasis 616(1)

Scabies and Pediculosis 616(1)

Antiparasitic Drugs 617(8)

Principles of Therapy 625(4)
SECTION VII Drugs Affecting Hematopoiesis and the Immune System 629(68)

Physiology of the Hematopoietic and Immune Systems 631(10)

Hematopoiesis 632(1)

Hematopoietic Cytokines 632(2)

Overview of Body Defense Mechanisms 634(1)

Immunity 634(1)

Immune Cells 635(3)

Patient-Related Factors that Influence Immune Function 638(1)

Immune Disorders 639(1)

Drugs that Alter Hematopoietic and Immune Responses 640(1)

Immunizing Agents 641(18)

Immunization 642(1)

Agents For Active Immunity 642(7)

Agents For Passive Immunity 649(1)

Individual Immunizing Agents 650(3)

Principles of Therapy 653(6)

Hematopoietic and Immunostimulant Drugs 659(14)

Overview 660(2)

Characteristics of Hematopoietic and Immunostimulant Drugs 662(3)

Principles of Therapy 665(8)

Immunosuppressants 673(24)

Description 674(1)

Autoimmune Disorders 674(1)

Tissue and Organ Transplantation 674(3)

Immunosuppressant Drugs 677(6)

Principles of Therapy 683(14)
SECTION VIII Drugs Affecting the Respiratory System 697(44)

Physiology of the Respiratory System 699(4)

The Respiratory System 700(2)

Disorders of the Respiratory System 702(1)

Drug Therapy 702(1)

Bronchodilating and Other Antiasthmatic Drugs 703(14)

Respiratory Disorders 704(1)

Drug Therapy 704(7)

Principles of Therapy 711(6)

Antihistamines 717(13)

Histamine and Its Receptors 718(1)

Hypersensitivity (Allergic) Reactions 718(3)

Antihistamines 721(5)

Principles of Therapy 726(4)

Nasal Decongestants, Antitussives, Mucolytics, and Cold Remedies 730(11)

Description 731(1)

The Common Cold 731(1)

Sinusitis 731(1)

Common Signs and Symptoms of Respiratory Disorders 731(1)

Drugs for Respiratory Disorders 732(1)

Individual Drugs 733(1)

Principles of Therapy 734(7)
SECTION IX Drugs Affecting the Cardiovascular System 741(140)

Physiology of the Cardiovascular System 743(5)

Heart 744(1)

Blood Vessels 744(1)

Blood 745(1)

Cardiovascular Disorders 746(1)

Drug Therapy in Cardiovascular Disorders 746(2)

Drug Therapy of Heart Failure 748(16)

Heart Failure 749(1)

Drug Therapy 750(6)

Principles of Therapy 756(8)

Antiarrhythmic Drugs 764(18)

Cardiac Electrophysiology 765(1)

Cardiac Arrhythmias 766(1)

Antiarrhythmic Drugs 766(4)

Classifications and Individual Drugs 770(5)

Principles of Therapy 775(7)

Antianginal Drugs 782(16)

Angina Pectoris 783(2)

Antianginal Drugs 785(7)

Principles of Therapy 792(6)

Drugs Used in Hypotension and Shock 798(10)

Hypotension and Shock 799(1)

Antishock Drugs 799(2)

Individual Drugs 801(2)

Principles of Therapy 803(5)

Antihypertensive Drugs 808(23)

Regulation of Arterial Blood Pressure 809(3)

Hypertension 812(1)

Antihypertensive Drugs 812(3)

Individual Drugs 815(5)

Principles of Therapy 820(11)

Diuretics 831(16)

Description 832(1)

Renal Physiology 832(2)

Alterations in Renal Function 834(1)

Diuretic Drugs 835(4)

Principles of Therapy 839(8)

Drugs That Affect Blood Coagulation 847(21)

Description 848(1)

Hemostasis 848(1)

Clot Lysis 848(3)

Thrombotic and Thromboembolic Disorders 851(1)

Drugs Used in Thrombotic and Thromboembolic Disorders 851(9)

Principles of Therapy 860(8)

Drugs for Hyperlipidemia 868(13)

Antilipemic Drugs 869(1)

Atherosclerosis 869(1)

Blood Lipids 869(1)

Hyperlipidemia 869(2)

Initial Management of Hyperlipidemia 871(1)

Drug Therapy of Hyperlipidemia 872(4)

Principles of Therapy 876(5)
SECTION X Drugs Affecting the Digestive System 881(56)

Physiology of the Digestive System 883(4)

The Digestive System 884(1)

Organs of the Digestive System 884(1)

Secretions of the Digestive System 885(1)

Effects of Drugs on the Digestive System 886(1)

Drugs Used in Peptic Ulcer Disease 887(17)

Peptic Ulcer Disease 888(1)

Types of Antiulcer Drugs 889(6)

Principles of Therapy 895(9)

Laxatives and Cathartics 904(10)

Description 905(1)

Defecation 905(1)

Laxatives and Cathartics 905(4)

Principles of Therapy 909(5)

Antidiarrheals 914(12)

Description 915(6)

Antidiarrheal Drugs 921(1)

Principles of Therapy 921(5)

Antiemetics 926(11)

Nausea and Vomiting 927(1)

Antiemetic Drugs 927(5)

Principles of Therapy 932(5)
SECTION XI Drugs Used in Special Conditions 937(83)

Drugs Used in Oncologic Disorders 939(28)

Characteristics of Normal Cells 940(1)

Characteristics of Malignant Neoplasms 940(4)

Antineoplastic Drugs 944(2)

Individual Drugs 946(5)

Cytoprotectant Drugs 951(5)

Principles of Therapy 956(11)

Drugs Used in Ophthalmic Conditions 967(16)

Structures of the Eye 968(1)

Disorders of the Eye 968(1)

Types of Ophthalmic Drugs 969(1)

Ophthalmic Drug Therapy 970(1)

Individual Drugs 970(5)

Principles of Therapy 975(8)

Drugs Used in Dermatologic Conditions 983(17)

Characteristics of the Skin 984(1)

Disorders of the Skin 984(2)

Types of Dermatologic Drugs 986(1)

Individual Drugs 987(6)

Principles of Therapy 993(7)

Drug Use During Pregnancy and Lactation 1000(20)

Pregnancy and Lactation 1001(1)

Maternal-Placental-Fetal Circulation 1001(1)

Drug Effects on the Fetus 1002(5)

Fetal Therapeutics 1007(1)

Maternal Therapeutics 1007(3)

Abortifacients 1010(1)

Tocolytics 1011(1)

Drugs Used During Labor and Delivery at Term 1011(1)

Neonatal Therapeutics 1012(1)

Principles of Therapy 1013(7)
Appendix A Recently Approved and Miscellaneous Drugs 1020(2)
Appendix B The International System of Units 1022(1)
Appendix C Therapeutic Serum Drug Concentrations for Selected Drugs 1023(1)
Appendix D Canadian Drug Laws and Standards 1024(1)
Appendix E Canadian Drug Names 1025