简介
Summary:
Publisher Summary 1
The final volume of the reference on therapeutic designer drugs. Highlights the link between chemical structure and biological activity, and explores chemotherapeutic agents, central-nervous-system and endocrine drugs, and radiological agents. Describes agents used against malaria, depression, anxiety, psychosis, inflammation, and viruses; others that affect the action of prostaglandins, leukotrienes, and thromboxanes; histamine receptor antagonists; anti- inflammatory steroids; and radiopaques. Includes an index to the entire set in addition to one for the volume. Annotation c. by Book News, Inc., Portland, Or.
Publisher Summary 2
The final volume in the standard-setting reference on therapeutic designed drugs . . .
BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, FIFTH EDITION, Volume 5: Therapeutic Agents
This volume on Therapeutic Agents completes Burger's incisive, systematic examination of the fascinating new world of custom-designed therapeutic agents. Volume 5 highlights the link between chemical structure and biological activity, and explores chemotherapeutic agents, CNS and endocrine drugs, and radiological agents. It continues the authoritative coverage begun in earlier volumes and contains a comprehensive index for the entire edition.
* Antimalarial agents
* Agents affecting the action of
* Cognition enhancers, agents, and prostaglandins pharmacodynamic models for
* Agents affecting the action of Alzheimer's disease leukotrienes and thromboxanes
* Antidepressant agent
* Histamine H1 receptor antagonists
* Antianxiety agents
* Antiviral agents, RNA viruses
* Antipsychotic agents other than HIV
* Antihistamines, topical ocular
* Radiopaques
* Antiinflammatory steroids
Essential to research in drug discovery and design, Volume 5 of Burger's Medicinal Chemistry and Drug Discovery is a cornerstone reference for professionals in the biopharmaceutical industry and academic research.
Burger's Medicinal Chemistry, Fifth Edition consists of five volumes:
* Volume 1: Principles and Practice (0-471-57556-9) 1994
* ". . . an essential addition to the libraries of any medicinal chemist . . . an outstanding work . . . highly praised as a fountain of information in drug studies and research."--Journal of Medicinal Chemistry
* Volume 2: Therapeutic Agents (0-471-57557-7) 1996
* Volume 3: Therapeutic Agents (0-471-57558-5) 1996
* Volume 4: Therapeutic Agents (0-471-57559-3) 1997
* Volume 5: Therapeutic Agents (0-471-57560-7) 1997
目录
Table Of Contents:
Part I Chemotherapeutic Agents, Pt. 3 1(92)
59. ANTIMALARIAL AGENTS
Dee Ann Casteel Bucknell University Lewisburg, Pennsylvania, USA
Part II CNS Drugs, Pt. 2 93(160)
60. COGNITION ENHANCERS, AGENTS, AND PHARMACODYNAMIC MODELS FOR ALZHEIMER'S DISEASE 95(26)
Michael F. Murphy Worldwide Clinical Trials Kennesaw, Georgia, USA
Klaudius R. Siegfried Hoechst AG Frankfurt, Germany
61. ANTIDEPRESSANT AGENTS 121(32)
Lisa D. Green and Karon Dawkins University of North Carolina Chapel Hill, North Carolina, USA
62. ANTIANXIETY AGENTS 153(42)
P. V. Nickell Allegheny University of the Health Sciences Pittsburgh, Pennsylvania, USA
Herbert E. Ward, Jr. Department of Psychiatry, Specialty Clinics University of Florida Gainesville, Florida, USA
Raymond G. Booth School of Pharmacy University of North Carolina Chapel Hill, North Carolina
63. ANTIPSYCHOTIC AGENTS 195(58)
Arnold R. Martin College opf Pharmacy University of Arizona Tucson, Arizona, USA
Part III Endocrine Drugs, Pt.2 253(384)
64. ANTIHISTAMINES, TOPICAL OCULAR 255(26)
N. A. Sharif
M. R. Hellberg
J. M. Yanni Alcon Laboratories, Inc. Fort Worth, Texas, USA
65. ANTIINFLAMMATORY STEROIDS 281(96)
Mitchell A. Avery
John R. Woolfrey Dept. of Medicinal Chemistry School of Pharmacy University of Mississippi University, Mississippi, USA
66. AGENTS AFFECTING THE ACTION OF PROSTAGLANDINS 377(28)
Donald T. Witiak School of Pharmacy University of Wisconsin Madison, Wisconsin, USA
Robert K. Griffith West Virginia School of Pharmacy Morgantown, West Virginia, USA
67. AGENTS AFFECTING THE ACTION OF LEUKOTRIENES AND THROMBOXANES 405(90)
Peter Bernstein Zeneca Pharmaceuticals Wilmington, Delaware, USA
T. Geoffrey Bird Zeneca Pharmaceuticals Reims, France
Andrew G. Brewster Zeneca Pharmaceuticals Macclesfield, United Kingdom
68. HISTAMINE H1 RECEPTOR ANTAGONISTS 495(66)
Henk Timmerman
Ming-Qiang Zhang
Rob Leurs Vrije University Amsterdam, The Netherlands
69. ANTIVIRAL AGENTS, RNA VIRUSES OTHER THAN HIV 561(76)
Catherine Laughlin
Christopher K. Tseng National Institutes of Health Rockville, Maryland, USA
Part IV Radiological Agents, Pt. 2 637(110)
70. RADIOPAQUES 639(108)
C. T. Peng Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, California and Department of Chemistry, Nuclear Science Facility, San Jose State University San Jose, California
INDEX 747(22)
CUMULATIVE INDEX, VOLUMES 1-5 769
Part I Chemotherapeutic Agents, Pt. 3 1(92)
59. ANTIMALARIAL AGENTS
Dee Ann Casteel Bucknell University Lewisburg, Pennsylvania, USA
Part II CNS Drugs, Pt. 2 93(160)
60. COGNITION ENHANCERS, AGENTS, AND PHARMACODYNAMIC MODELS FOR ALZHEIMER'S DISEASE 95(26)
Michael F. Murphy Worldwide Clinical Trials Kennesaw, Georgia, USA
Klaudius R. Siegfried Hoechst AG Frankfurt, Germany
61. ANTIDEPRESSANT AGENTS 121(32)
Lisa D. Green and Karon Dawkins University of North Carolina Chapel Hill, North Carolina, USA
62. ANTIANXIETY AGENTS 153(42)
P. V. Nickell Allegheny University of the Health Sciences Pittsburgh, Pennsylvania, USA
Herbert E. Ward, Jr. Department of Psychiatry, Specialty Clinics University of Florida Gainesville, Florida, USA
Raymond G. Booth School of Pharmacy University of North Carolina Chapel Hill, North Carolina
63. ANTIPSYCHOTIC AGENTS 195(58)
Arnold R. Martin College opf Pharmacy University of Arizona Tucson, Arizona, USA
Part III Endocrine Drugs, Pt.2 253(384)
64. ANTIHISTAMINES, TOPICAL OCULAR 255(26)
N. A. Sharif
M. R. Hellberg
J. M. Yanni Alcon Laboratories, Inc. Fort Worth, Texas, USA
65. ANTIINFLAMMATORY STEROIDS 281(96)
Mitchell A. Avery
John R. Woolfrey Dept. of Medicinal Chemistry School of Pharmacy University of Mississippi University, Mississippi, USA
66. AGENTS AFFECTING THE ACTION OF PROSTAGLANDINS 377(28)
Donald T. Witiak School of Pharmacy University of Wisconsin Madison, Wisconsin, USA
Robert K. Griffith West Virginia School of Pharmacy Morgantown, West Virginia, USA
67. AGENTS AFFECTING THE ACTION OF LEUKOTRIENES AND THROMBOXANES 405(90)
Peter Bernstein Zeneca Pharmaceuticals Wilmington, Delaware, USA
T. Geoffrey Bird Zeneca Pharmaceuticals Reims, France
Andrew G. Brewster Zeneca Pharmaceuticals Macclesfield, United Kingdom
68. HISTAMINE H1 RECEPTOR ANTAGONISTS 495(66)
Henk Timmerman
Ming-Qiang Zhang
Rob Leurs Vrije University Amsterdam, The Netherlands
69. ANTIVIRAL AGENTS, RNA VIRUSES OTHER THAN HIV 561(76)
Catherine Laughlin
Christopher K. Tseng National Institutes of Health Rockville, Maryland, USA
Part IV Radiological Agents, Pt. 2 637(110)
70. RADIOPAQUES 639(108)
C. T. Peng Department of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, California and Department of Chemistry, Nuclear Science Facility, San Jose State University San Jose, California
INDEX 747(22)
CUMULATIVE INDEX, VOLUMES 1-5 769
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