Computational analysis of biochemical systems : a practical guide for biochemists and molecular b...

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作   者:Eberhard O. Voit ; software PLAS by Ant髇io Ferreira.

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ISBN:9780521785792

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简介

Summary: Publisher Summary 1 A true understanding of genetic and metabolic function and design is facilitated by mathematical and computational methods for analyzing biochemical systems. This hands-on reference teaches biochemists and molecular biologists the use of modern computational methods for the analysis of complex biomedical systems requiring a modest mathematical background. The book begins with representations of biochemical systems, provides guidelines for setting up models, details mathematical and computational methods of parameter estimation and model analysis, and connects to the modern literature with four detailed case studies. Every step is illustrated with examples and explored with accompanying PLAS software. The volume also features over 250 exercises with about one quarter fully or partially solved.   Publisher Summary 2 Teaches the use of modern computational methods for the analysis of biomedical systems using case studies and accompanying software.  

目录

Preface
Introduction
Graphical representation of biochemical systems
Models of biochemical systems
From maps to equations
Computer simulation
Parameter estimation
Analytical steady-state evaluation
Sensitivity analysis
Case study 1 - Anaerobic fermentation pathway in Saccharomyces cerevisiae
Case study 2 - diagnosis and refinement of a model of the tricarboxylic acid cycle in Dictyostelium discoideum
Case study 3 - A sequence of models describing purine metabolism
Case study 4 - Algebraic analysis of the initial steps of the Glycolytic-Glycogenolytic pathway in perfused rat liver
Epilogue-Canonical modeling beyond biochemistry
Appendix
Hints and solutions
References
Author index
Subject Index

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