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简介
This is a completely revised and expanded edition of the Guidebook to Biochemistry. Every chapter has been reviewed and brought up to date. A new chapter, on the cell and membrane transport, has been included, and the single chapter on regulation in the previous edition has been greatly enlarged and divided into two chapters. Other topics that have received particular attention in this edition include lipids, cell membranes and the biochemical action of hormones. The chapter on genetics has been revised to take account of recent studies of the genetic organization of higher organisms, and a section on genetic engineering has been included. In making these changes the authors have taken care to adhere to the concept of the 'Guidebook' introduced by Kenneth Harrison and maintained by them in the 1971 edition: to 'introduce the reader to the important features of the subject by exemplifying and discussing crucial biochemical concepts'. For this reason they have been careful to restrict the increase in the total length of the book compared with the 1971 edition.
目录
Preface p. vii
Acknowledgements p. viii
Conventions and abbreviations p. ix
Introduction p. 1
Structure and function of macromolecules
Introduction to macromolecules p. 5
Protein structure p. 15
Protein function I p. 30
Protein function II--the enzymes p. 44
Nucleic acids, polysaccharides and lipids p. 52
Metabolism
Energy and biochemical reactions p. 93
The oxidative pathway and oxidative phosphorylation p. 107
Introduction to intermediary metabolism p. 119
Synthesis of ATP--glycolysis p. 125
Synthesis of ATP--the Krebs cycle p. 133
Synthesis of ATP--fat breakdown p. 140
Synthesis of ATP and NADPH[subscript 2]--the pentose phosphate pathway p. 145
Synthesis of ATP and NADPH[subscript 2]--the light reaction of photosynthesis p. 151
Uses of ATP and NADPH[subscript 2]--the synthesis of polysaccharides p. 155
Uses of ATP and NADPH[subscript 2]--the synthesis of fats p. 167
Amino-acid metabolism p. 172
Molecular genetics and protein synthesis
The molecular basis of genetics p. 183
Synthesis of DNA and RNA p. 189
Synthesis of proteins p. 202
Compartmentation and regulation
The cell and membrane transport p. 215
Control of enzyme synthesis p. 228
Control of enzymic activity, and an introduction to hormones p. 237
Index p. 245
Acknowledgements p. viii
Conventions and abbreviations p. ix
Introduction p. 1
Structure and function of macromolecules
Introduction to macromolecules p. 5
Protein structure p. 15
Protein function I p. 30
Protein function II--the enzymes p. 44
Nucleic acids, polysaccharides and lipids p. 52
Metabolism
Energy and biochemical reactions p. 93
The oxidative pathway and oxidative phosphorylation p. 107
Introduction to intermediary metabolism p. 119
Synthesis of ATP--glycolysis p. 125
Synthesis of ATP--the Krebs cycle p. 133
Synthesis of ATP--fat breakdown p. 140
Synthesis of ATP and NADPH[subscript 2]--the pentose phosphate pathway p. 145
Synthesis of ATP and NADPH[subscript 2]--the light reaction of photosynthesis p. 151
Uses of ATP and NADPH[subscript 2]--the synthesis of polysaccharides p. 155
Uses of ATP and NADPH[subscript 2]--the synthesis of fats p. 167
Amino-acid metabolism p. 172
Molecular genetics and protein synthesis
The molecular basis of genetics p. 183
Synthesis of DNA and RNA p. 189
Synthesis of proteins p. 202
Compartmentation and regulation
The cell and membrane transport p. 215
Control of enzyme synthesis p. 228
Control of enzymic activity, and an introduction to hormones p. 237
Index p. 245
A guidebook to biochemistry 2nd ed.
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