简介
《硒蛋白及其模拟物(英文版)》主要内容简介：Selenium has a long history of association with human health and disease. This essential trace element exerts its important biological role in selenoproteins. Selenoproteins and Mimics presents the latest developments in selenoproteins, their functional imitation by biomi-metic chemistry and biology, and their relationship with human health and diseases. This book provides both the basic biology and biochemistry knowledge of selenoproteins, and sophisticated approaches for the development of new selenoprotein mimics. It's a valuable reference for researchers in biological technology, chemical syntheses, and medicine design.
目录
1 Glutathione Peroxidases
1.1 Introduction
1.2 Glutathione Peroxidase Reaction
1.2.1 Basic Catalytic Principle
1.2.2 Kinetics
1.2.3 Physiological Consequences of Kinetic Mechanism
1.2.4 Facts, Unknowns and Guesswork
1.3 Biological Roles of Individual Glutathione Peroxidases
1.3.1 GPx1
1.3.2 GPx2
1.3.3 GPx3
1.3.4 GPx4
1.3.5 GPx5-GPx8
1.4 Conclusions and Perspectives
References
2 Thyroid Hormone Deiodinases
2.1 Introduction
2.2 Thyroid Hormones
2.3 Deiodinases
2.3.1 Structure
2.3.2 Control
2.4 Role of Deiodinase in TH Actions
2.4.1 Photoperiod
2.4.2 Nutrition
2.4.3 Thermogenesis
2.4.4 Osmoregulation
2.4.5 Reproduction
2.4.6 Development, Including Metamorphosis
2.4.7 Developmental Genes
2.5 Evolution
References
3 Thioredoxin Reductase
3.1 Introduction
3.2 Selenium in Mammalian TrxR
3.3 Outline of Mammalian TrxR
3.3.1 Isoenzymes
3.3.2 Sec Incorporation
3.3.3 cDNAs and Genes
3.4 Regulation of Mammalian TrxR
3.4.1 Se-dependent Regulation
3.4.2 Regulation of Gene Expression
3.5 Structure
3.5.1 Functional Elements in Primary Structure
3.5.2 Functional Elements in Three-dimensional Structure
3.6 Proposed Mechanisms Underlying TrxR-I Catalysis
3.6.1 Electron Transfer Pathway
3.6.2 Acid-base Catalyst
3.6.3 Catalytic Roles of the Sec Residue
3.7 Roles of Mammalian TrxRs in Cell Growth and Apoptosis
3.7.1 Cross-talk with Glutathione System
3.7.2 Control of Cell Growth
3.7.3 Regulation of Apoptosis
References
4 Selenophosphate Synthetase
4.1 Introduction
4.2 Selenoprotein Biosynthesis in Prokaryotes
4.3 Structure of PurM Monomer and Selenophosphate Synthetase
4.3.1 Structure of PurM Monomer
4.3.2 Structure of Human SPS1
4.4 Cayalytic Mechanism of Selenophosphate Synthetase
4.5 SelD for Development and Cell Proliferation
4.6 Conclusion
References
5 Selenoprotein P
5.1 Introduction
5.2 Structural Features of SeP
5.2.1 Selenium Content of Human SeP
……
6 Selenoprotein T
7 Selenoprotein W
8 Selenoprotein Biosynthesis
9 Bioinformatics of Selenoproteins
10 Selenoproteins and Atherosclerosis
11 Selenoproteins and Brain Diseases
12 Selenoproteins and Thyroid Cancer
13 Selenoproteins and Selenium Speciation in Food
14 Synthetic Mimics of Selenoproteins
15 Cyclodextrin-based Mimics of Selenoproteins
16 Semisynthesized Selenoproteins
17 Selenium-containing Catalytic Antibodies
18 Biosynthetic Mimics of Selenoproteins
19 Nanoenzymes as Selenoprotein Mimics
20 Selenprotein Mimics and Diseases
Index
1.1 Introduction
1.2 Glutathione Peroxidase Reaction
1.2.1 Basic Catalytic Principle
1.2.2 Kinetics
1.2.3 Physiological Consequences of Kinetic Mechanism
1.2.4 Facts, Unknowns and Guesswork
1.3 Biological Roles of Individual Glutathione Peroxidases
1.3.1 GPx1
1.3.2 GPx2
1.3.3 GPx3
1.3.4 GPx4
1.3.5 GPx5-GPx8
1.4 Conclusions and Perspectives
References
2 Thyroid Hormone Deiodinases
2.1 Introduction
2.2 Thyroid Hormones
2.3 Deiodinases
2.3.1 Structure
2.3.2 Control
2.4 Role of Deiodinase in TH Actions
2.4.1 Photoperiod
2.4.2 Nutrition
2.4.3 Thermogenesis
2.4.4 Osmoregulation
2.4.5 Reproduction
2.4.6 Development, Including Metamorphosis
2.4.7 Developmental Genes
2.5 Evolution
References
3 Thioredoxin Reductase
3.1 Introduction
3.2 Selenium in Mammalian TrxR
3.3 Outline of Mammalian TrxR
3.3.1 Isoenzymes
3.3.2 Sec Incorporation
3.3.3 cDNAs and Genes
3.4 Regulation of Mammalian TrxR
3.4.1 Se-dependent Regulation
3.4.2 Regulation of Gene Expression
3.5 Structure
3.5.1 Functional Elements in Primary Structure
3.5.2 Functional Elements in Three-dimensional Structure
3.6 Proposed Mechanisms Underlying TrxR-I Catalysis
3.6.1 Electron Transfer Pathway
3.6.2 Acid-base Catalyst
3.6.3 Catalytic Roles of the Sec Residue
3.7 Roles of Mammalian TrxRs in Cell Growth and Apoptosis
3.7.1 Cross-talk with Glutathione System
3.7.2 Control of Cell Growth
3.7.3 Regulation of Apoptosis
References
4 Selenophosphate Synthetase
4.1 Introduction
4.2 Selenoprotein Biosynthesis in Prokaryotes
4.3 Structure of PurM Monomer and Selenophosphate Synthetase
4.3.1 Structure of PurM Monomer
4.3.2 Structure of Human SPS1
4.4 Cayalytic Mechanism of Selenophosphate Synthetase
4.5 SelD for Development and Cell Proliferation
4.6 Conclusion
References
5 Selenoprotein P
5.1 Introduction
5.2 Structural Features of SeP
5.2.1 Selenium Content of Human SeP
……
6 Selenoprotein T
7 Selenoprotein W
8 Selenoprotein Biosynthesis
9 Bioinformatics of Selenoproteins
10 Selenoproteins and Atherosclerosis
11 Selenoproteins and Brain Diseases
12 Selenoproteins and Thyroid Cancer
13 Selenoproteins and Selenium Speciation in Food
14 Synthetic Mimics of Selenoproteins
15 Cyclodextrin-based Mimics of Selenoproteins
16 Semisynthesized Selenoproteins
17 Selenium-containing Catalytic Antibodies
18 Biosynthetic Mimics of Selenoproteins
19 Nanoenzymes as Selenoprotein Mimics
20 Selenprotein Mimics and Diseases
Index
- 名称
- 类型
- 大小
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