Protein Degradation. V.4, the ubiquitin-proteasome system and disease /

Preface
List of Contributors.
Ubiquitin Signaling and Cancer Pathogenesis Kaisa Haglund and Ivan Dikic
1.1 Introduction
1.2 Ubiquitin in Cancer Pathogenesis
1.3 Targeting Ubiquitin Networks in Cancers
1.4 Conclusions and Future Perspectives
2 Regulation of the p53 Tumor-suppressor Protein by Ubiquitin and Ubiquitin-like Molecules Dimitris P. Xirodimas
2.1 Functional Domains of p53
2.2 The Family of Ubiquitin-like Molecules
2.3 E3 Ligases for p53
2.4 Modifi cation of p53 with Ubiquitin
2.5 Requirements for Mdm2-mediated Ubiquitination of p53
2.6 Regulation of p53 Ubiquitination
2.7 De-ubiquitination of p53
2.8 SUMO-1/sentrin/smpt3
2.9 NEDD8/Rub1
2.10 Therapeutic Intervention through the Ubiquitin Pathway
3 The Ubiquitin-Proteasome System in Epstein-Barr Virus Infection and Oncogenesis Maria G. Masucci
3.1 Introduction
3.2 Viral Interference with the Ubiquitin-Proteasome System
3.3 The EBV Life Cycle
3.4 EBV and the Ubiquitin-Proteasome System
3.5 EBV-associated Malignancies
3.6 Concluding Remarks
4 HECT Ubiquitin-protein Ligases in Human Disease Martin Scheffner and Olivier Staub
4.1 Introduction
4.2 Defi nition of HECT E3s
4.3 Human HECT E3s and their Role in Disease
4.4 E6-AP
4.5 HECTH9
4.6 HECT E3s with WW Domains
4.7 Concluding Remarks
5 Ubiquitin-independent Mechanisms of Substrate Recognition and Degradation by the Proteasome Martin A. Hoyt and Philip Coffino
5.1 Introduction
5.2 Ubiquitin-independent Proteasome Substrates
5.3 Mechanisms of Ubiquitin-independent Degradation
5.4 Conclusion
6 Endoplasmic Reticulum Protein Quality Control and Degradation Antje Sch盲fer and Zlatka Kostova and Dieter H. Wolf
6.1 Introduction
6.2 ER-import, Folding and the Unfolded Protein Response
6.3 General Principles and Components of ERQD (Endoplasmic Reticulum Quality Control and Protein Degradation)
6.4 Mechanism of ERQD.6.5 "Overfl ow" Degradation Pathways: ER-to-Golgi Transport and Autophagocytosis
6.6 The Retrotranslocation Channel
6.7 Metazoan ERQD
7 Interactions between Viruses and the Ubiquitin-Proteasome System Jessica M. Boname and Paul J. Lehner
7.1 Introduction
7.2 Overview of Viruses and the Ubiquitin-Proteasome System
7.3 Viruses and E3 Ubiquitin-Protein Ligases
7.4 Conclusions
8 The Ubiquitin-Proteasome System in Parkinson's Disease Kevin St. P. McNaught
8.1 Introduction
8.2 Protein Handling in the CNS
8.3 The UPS and Protein Mishandling in PD
8.4 Parkin
8.5 UCH-L1
8.6 驴-Synuclein
8.7 Dardarin/LRRK2
8.8 PINK1
8.9 DJ-1
8.10 Proteasomal Dysfunction in Sporadic PD
8.11 Conclusion
9 The Molecular Pathway to Neurodegeneration in Parkin-Related Parkinsonism Ryosuke Takahashi
9.1 Introduction
9.2 Parkin is an E3 Ubiquitin Ligase
9.3 Substrates of Parkin
9.4 The Animal Models of AR-JP
9.5 Future Directions