Lipids and atherosclerosis /
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作 者：edited by C.J. Packard and D.J. Rader,foreword by V. Fuster.
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ISBN：9781842142295
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简介
"Lipids and Atherosclerosis comprehensively explores the array of new discoveries in genetics, molecular and cell biology in the last two decades, particularly in regard to lipidology and the treatment of cardiovascular disease." "With a real focus on the dynamic and often changing developments across a broad range of disciplines, Lipids and Atherosclerosis is an authoritative overview of the cutting-edge key advances in the treatment of cardiovascular disease, and is ideal for cardiologists and biomedical researchers in cardiology, vascular biology, endocrinology and lipidology."--BOOK JACKET.
目录
List of contributors p. vii
Foreword p. xi
Preface p. xiii
Acknowledgements p. xiv
1 The assembly of very low density lipoproteins in the liver S-O. Olofsson and L. Asp p. 1
2 Cardiovascular implications of partial, tissue-specific silencing of MTP C.C. Shoulders p. 15
3 Acyl CoA: Diacylglycerol acyltransferases (DGATs) as therapeutic targets for cardiovascular disease J.S. Millar and J.T. Billheimer p. 31
4 The biochemical and physiological roles of ACAT1 and ACAT2 in cholesterol homeostasis and atherosclerosis R.G. Lee and L.L. Rudel p. 41
5 Overview of intestinal lipid metabolism T.A. Miettinen and H. Gylling p. 55
6 The role of non-cholesterol sterols in the pathogenesis of atherosclerosis and their modulation by the sitosterolaemia locus E.L. Klett and S.B. Patel p. 63
7 FXR: the molecular link between bile acid and lipid metabolism T. Claudel and E. Sturm and B. Staels and F. Kuipers p. 69
8 Overview of HDL and reverse cholesterol transport P. Barter p. 81
9 LXR as a therapeutic target for atherosclerosis I.G. Schulman and R.A. Heyman p. 93
10 Endothelial lipase and the regulation of HDL metabolism K.O. Badellino and W. Jin p. 101
11 Cholesteryl ester transfer protein (CETP) inhibition as a therapeutic strategy for raising HDL-cholesterol levels and reducing atherosclerosis D.J. Rader p. 111
12 Overview of insulin resistance and the metabolic syndrome N. Sattar and B. Mukhopadhyay p. 119
13 Peroxisome proliferator activated receptors and energy metabolism P. Gervois and J-C. Fruchart and B. Staels p. 137
14 Adipocytes and their secretory products J.B. Prins p. 153
15 Regulation of adipocyte triglyceride storage F. Karpe and G.D. Tan p. 165
16 Role of innate immunity in atherosclerosis: immune recognition, immune activation and the atherosclerotic process J-M. Fernandez-Real p. 175
17 Role of CD44 in atherogenesis and its potential role as a therapeutic target E. Pure p. 191
18 Lipoxygenases: potential therapeutic target in atherosclerosis L. Zhao and C.D. Funk p. 207
19 Role of secretory phospholipase A[subscript 2] isozymes (Lp-PLA[subscript 2]) C.H. Macphee p. 219
Index p. 231
Foreword p. xi
Preface p. xiii
Acknowledgements p. xiv
1 The assembly of very low density lipoproteins in the liver S-O. Olofsson and L. Asp p. 1
2 Cardiovascular implications of partial, tissue-specific silencing of MTP C.C. Shoulders p. 15
3 Acyl CoA: Diacylglycerol acyltransferases (DGATs) as therapeutic targets for cardiovascular disease J.S. Millar and J.T. Billheimer p. 31
4 The biochemical and physiological roles of ACAT1 and ACAT2 in cholesterol homeostasis and atherosclerosis R.G. Lee and L.L. Rudel p. 41
5 Overview of intestinal lipid metabolism T.A. Miettinen and H. Gylling p. 55
6 The role of non-cholesterol sterols in the pathogenesis of atherosclerosis and their modulation by the sitosterolaemia locus E.L. Klett and S.B. Patel p. 63
7 FXR: the molecular link between bile acid and lipid metabolism T. Claudel and E. Sturm and B. Staels and F. Kuipers p. 69
8 Overview of HDL and reverse cholesterol transport P. Barter p. 81
9 LXR as a therapeutic target for atherosclerosis I.G. Schulman and R.A. Heyman p. 93
10 Endothelial lipase and the regulation of HDL metabolism K.O. Badellino and W. Jin p. 101
11 Cholesteryl ester transfer protein (CETP) inhibition as a therapeutic strategy for raising HDL-cholesterol levels and reducing atherosclerosis D.J. Rader p. 111
12 Overview of insulin resistance and the metabolic syndrome N. Sattar and B. Mukhopadhyay p. 119
13 Peroxisome proliferator activated receptors and energy metabolism P. Gervois and J-C. Fruchart and B. Staels p. 137
14 Adipocytes and their secretory products J.B. Prins p. 153
15 Regulation of adipocyte triglyceride storage F. Karpe and G.D. Tan p. 165
16 Role of innate immunity in atherosclerosis: immune recognition, immune activation and the atherosclerotic process J-M. Fernandez-Real p. 175
17 Role of CD44 in atherogenesis and its potential role as a therapeutic target E. Pure p. 191
18 Lipoxygenases: potential therapeutic target in atherosclerosis L. Zhao and C.D. Funk p. 207
19 Role of secretory phospholipase A[subscript 2] isozymes (Lp-PLA[subscript 2]) C.H. Macphee p. 219
Index p. 231
Lipids and atherosclerosis /
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