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Summary: Publisher Summary 1 The dates of earlier editions are not stated, but this fifth edition has undergone some radical updates including substantial integration with an associated website where the book's contents can be accessed along with illustrative videos (their presence is indicated in the margins with an icon). The editorial team still includes John F. Murray and Jay A. Nadel, whose names are at the head of the title, as well as five other editors, two of whom, like Murray and Nadel, are affiliated with the U. of California, San Francisco, and the others with the U. of Colorado, U. of Washington, and U. of Illinois at Chicago. They state in their preface: "As it has been from the beginning, the goal of this textbook is to be a well balanced, authoritative, and fully documented book that integrates the basic scientific principles with the practice of respiratory medicine for clinicians, trainees, students and educators." Ninety-five contributed chapters, logically arranged, support that goal. Annotation 漏2011 Book News, Inc., Portland, OR (booknews.com)   Publisher Summary 2 Completely revised, the 4th Edition of this authoritative reference delivers a wealth of new information that enables readers to identify, treat, and manage a full range of respiratory disorders more easily than ever. Edited and written by leaders in the field, the book covers the scientific principles of respiratory medicine; its foundations in basic anatomy, physiology, pharmacology, pathology, and immunology; and its clinical applications. It features a wealth of new chapters * coverage of new modalities in biotechnologic, genomic, and informational sciences * a new 2-color design that makes it easier and quicker to access key information * and complete references for further study. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Covers the hottest topics in the field, including COPD guidelines and lung reduction surgery * better pharmacological control of asthma * first-line drug therapies for cancer * interstitial lung disease * thoracoscopic surgery * ARDS ventilation guidelines c and more. Includes 6 new chapters: Alveolar and Distal Airway Epithelial Fluid Transport * Mucus Production, Secretion, and Clearance * Pleuroscopy, Thoracoscopy, and Other Invasive Procedures * Clinical Exercise Testing * Smoking Hazards and Cessation * and Patient Education and Compliance. Offers a fresh editorial approach with the addition of 1 new editor. Features the work of 73 new authors, including international contributors. Incorporates 100 new full-color illustrations for a total of more than 1,250 images.   Publisher Summary 3 Completely revised, the 4th Edition of this authoritative reference delivers a wealth of new information that enables readers to identify, treat, and manage a full range of respiratory disorders more easily than ever. Edited and written by leaders in the field, the book covers the scientific principles of respiratory medicine; its foundations in basic anatomy, physiology, pharmacology, pathology, and immunology; and its clinical applications. It features a wealth of new chapters * coverage of new modalities in biotechnologic, genomic, and informational sciences * a new 2-color design that makes it easier and quicker to access key information * and complete references for further study. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Covers the hottest topics in the field, including COPD guidelines and lung reduction surgery * better pharmacological control of asthma * first-line drug therapies for cancer * interstitial lung disease * thoracoscopic surgery * ARDS ventilation guidelines c and more. Includes 6 new chapters: Alveolar and Distal Airway Epithelial Fluid Transport * Mucus Production, Secretion, and Clearance * Pleuroscopy, Thoracoscopy, and Other Invasive Procedures * Clinical Exercise Testing * Smoking Hazards and Cessation * and Patient Education and Compliance. Offers a fresh editorial approach with the addition of 1 new editor. Features the work of 73 new authors, including international contributors. Incorporates 100 new full-color illustrations for a total of more than 1,250 images.  

目录

Table Of Contents:

PART I SCIENTIFIC PRINCIPLES OF RESPIRATORY MEDICINE 1(2)

Section A Anatomy and Development of the Respiratory Tract 3(50)

1 Anatomy of the Lungs 3(23)

Kurt H. Albertine

2 Lung Growth and Development 26(12)

John M. Shannon

James M. Greenberg

3 Mendelian Genetics, Disease Modifying or Associated Genes, and Epigenetics of Lung Disease 38(15)

David A. Schwartz

Scott T. Weiss

Section B Respiratory Physiology and Pharmacology 53(147)

4 Ventilation, Blood Flow, and Gas Exchange 53(36)

Peter D. Wagner

Frank L Powell

John B. West

5 Respiratory System Mechanics and Energetics 89(19)

Najib T. Ayas

Spyros G. Zakynthinos

Charis Roussos

Peter D. Pare

6 Pulmonary Circulation and Regulation of Fluid Balance 108(26)

Jeffrey R. Jacobson

Joe G. N. Garcia

7 Acid-Base Balance 134(25)

Richard M. Effros

Erik R. Swenson

8 Pharmacologic Principles 159(41)

Peter J. Barnes

Section C Defense Mechanisms and Immunology 200(114)

9 Pulmonary Surfactant 200(17)

Robert J. Mason

James F. Lewis

10 Alveolar and Distal Airway Epithelial Fluid Transport 217(9)

Hans G. Folkesson

Michael A. Matthay

11 Airway Epithelial Mucins and Mucous Hypersecretion 226(10)

Jay A. Nadel

12 Aerosol, Deposition and Clearance 236(19)

Thomas G. O'Riordan

Gerald C. Smaldone

13 Innate Immunity in the Lungs 255(30)

David W.H. Riches

Richard T. Sawyer

Matthew J. Fenton

Thomas R. Martin

14 Adaptive Immunity 285(29)

Andrew P. Fontenot

Philip L Simonian

Section D Respiratory Pathology and Inflammation 314(33)

15 General Features of Non-Neoplastic Respiratory Pathology 314(16)

Rubin M. Tuder

Stephen Groshong

Carlyne D. Cool

16 Injury and Repair of the Lung 330(17)

Susan D. Reynolds

Peter M. Henson

Gregory P. Downey

Marc Moss

PART II DIAGNOSIS AND EVALUATION OF RESPIRATORY DISEASE 347(2)

Section E Diagnosis 349(173)

17 History and Physical Examination 349(19)

Dean E. Schraufnagel

John F. Murray

18 Microbiologic Diagnosis of Lower Respiratory Tract Infection 368(25)

Bobbi S. Pritt

Joseph D.C. Yao

19 Radiographic Techniques 393(52)

Michael B. Gotway

Brett M. Elicker

20 Ultrasonography 445(16)

Devanand Anantham

Armin Ernst

21 Nuclear Medicine Techniques 461(24)

Edward F. Patz

R. Edward Coleman

22 Flexible Bronchoscopy 485(21)

Elif Kupell

Demet Kamak

Atul C. Mehta

23 Pleuroscopy and Medical Thoracoscopy 506(16)

Robert Loddenkemper

Marc Noppen

Section F Evaluation 522(89)

24 Pulmonary Function Testing 522(32)

Matthew J. Hegewald

Robert O. Crapo

25 Clinical Exercise Testing 554(24)

Kathy E. Sietsema

26 Preoperative Evaluation 578(12)

Jeanine P. Wiener-Kronish

Kenneth E. Shepherd

Srinivas R. Bapoje

Richard K. Albert

27 Evaluation of Respiratory Impairment and Disability 590(21)

Annyce S. Mayer

Lisa A. Maier

PART III CLINICAL RESPIRATORY MEDICINE 611(2)

Section G Symptoms of Respiratory Disease and Their Management 613(48)

28 Dyspnea 613(15)

Richard M. Schwartzstein

Lewis Adams

29 Cough 628(19)

Kian Fan Chung

John G. Widdicombe

30 Chest Pain 647(14)

Teofilo Lee-Chiong

Gerald F. Gebhart

Richard A. Matthay

Section H Infectious Diseases of the Lungs 661(222)

31 Viral Infections 661(38)

F. Eun-Hyung Lee

John Treanor

32 Pyogenic Bacterial Pneumonia and Lung Abscess 699(42)

Antonl Torres

Rosario Menendez

Richard Wunderink

33 Ventilator-Associated Pneumonia 741(13)

Jean Chastre

Charles-Edouard Luyt

34 Tuberculosis 754(39)

Philip C. Hopewell

Midori Kato-Maeda

35 Nontuberculous Mycobacterial Infections 793(18)

Charles L. Daley

David E. Griffith

36 Fungal Infections 811(39)

Scott F. Davies

Kenneth S. Knox

George A. Sarosi

37 Parasitic Lung Infections 850(33)

James McCarthy

Thomas B. Nutman

Section I Obstructive Diseases 883(197)

38 Asthma 883(36)

Njira Lugogo

Loretta G. Que

Daniel Fertel

Monica Kraft

39 Chronic Bronchitis and Emphysema 919(49)

Steven D. Shapiro

John J. Rellly

Stephen I. Rennard

40 Smoking Hazards and Cessation 968(17)

Neal L. Benowitz

Paul G. Brunetta

41 Cystic Fibrosis 985(38)

Richard C. Boucher

Michael R. Knowles

James R. Yankaskas

42 Bronchiectasis 1023(24)

Michael D. Iseman

Edward D. Chan

43 Disorders of the Upper Airways 1047(19)

Ronald C. Balkissoon

Fuad M. Baroody

Alkis Togias

44 Disorders of the Intrathoracic Airways 1066(14)

Stephen C. Lazarus

Section J Neoplasms of the Lung 1080(106)

45 Biology of Non-Small Cell Lung Cancer 1080(18)

Pierre P. Massion

David P. Carbone

46 Epidemiology of Lung Cancer 1098(18)

Anthony J. Alberg

Jonathan M. Samet

47 Clinical Aspects of Lung Cancer 1116(29)

Gerard A. Silvestri

James R. Jett

48 Lymphoma, Lymphoproliferative Diseases, and Other Primary Malignant Tumors 1145(15)

Nicolas Girard

Jacques Cadranel

Elisabeth Brambilla

Jean-Francols Cordler

49 Metastatic Malignant Tumors 1160(11)

Douglas Arenberg

Allan Pickens

50 Benign Lung Tumors 1171(15)

Jeffrey L. Myers

Thomas J. Giordano

Section K Disorders of the Pulmonary Circulation 1186(170)

51 Pulmonary Thromboembolism 1186(38)

Timothy A. Morris

Peter F. Fedullo

52 Pulmonary Hypertension 1224(20)

Richard N. Channick

Lewis J. Rubin

53 Pulmonary Vasculitis 1244(17)

Kevin K. Brown

Carlyne D. Cool

54 Pulmonary Arteriovenous Malformations and other Vascular Abnormalities 1261(22)

Claire L. Shovlin

James E. Jackson

55 Pulmonary Edema and Acute Lung Injury 1283(43)

Michael A. Matthay

Thomas R. Martin

56 Cor Pulmonale 1326(30)

Dana McGlothlin

Teresa De Marco

Section L Infiltrative and Interstitial Lung Diseases 1356(181)

57 Idiopathic Interstitial Pneumonias 1356(42)

Moises Selman

Lake D. Morrison

Paul W. Noble

Talmadge E. King

58 The Lungs and Connective Tissue Diseases 1398(29)

Tamera J. Corte

Roland M. du Bois

Athol U. Wells

59 Sarcoidosis 1427(22)

Wonder Drake

Lee S. Newman

60 Diffuse Alveolar Hemorrhage and Rare Infiltrative Disorders of the Lung 1449(20)

Harold R. Collard

Talmadge E. King

Marvin I. Schwarz

61 Eosinophilic Lung Diseases 1469(27)

Vincent Cottin

Jean-Francois Cordier

62 Lymphangioleiomyomatosis 1496(20)

Francis X. McCormack

Eugene J. Sullivan

Yoshikazu Inoue

63 Pulmonary Alveolar Proteinosis Syndrome 1516(21)

Bruce C. Trapnell

Koh Nakata

Mani S. Kavuru

Section M Environmental and Occupational Disorders 1537(182)

64 Asthma in the Workplace and Occupational Asthma 1537(17)

Moira Chan-Yeung

Jean-Luc Malo

65 Pneumoconioses and Other Mineral Dust-Related Diseases 1554(33)

Robert L. Cowie

Jill Murray

Margaret R. Becklake

66 Hypersensitivity Pneumonitis 1587(14)

Cecile S. Rose

Abigail R. Lara

67 Indoor and Outdoor Air Pollution 1601(18)

Mark D. Eisner

John R. Balmes

68 Acute Pulmonary Responses To Toxic Exposures 1619(17)

Paul D. Blanc

69 Bioterrorism 1636(15)

Christian Sandrock

70 High Altitude 1651(20)

Andrew M. Luks

Robert B. Schoene

Erik R. Swenson

71 Diving Medicine 1671(20)

Alfred A. Bove

Thomas S. Neuman

72 Drug-Induced Pulmonary Disease 1691(28)

Fabien Maldonado

Andrew H. Limper

Section N Disorders of the Pleura 1719(95)

73 Pleural Effusion 1719(45)

V. Courtney Broaddus

Richard W. Light

74 Pneumothorax, Chylothorax, Hemothorax, and Fibrothorax 1764(28)

Richard W. Light

Y. C. Gary Lee

75 Tumors of the Pleura 1792(22)

V. Courtney Broaddus

Bruce W. S. Robinson

Section O Disorders of the Mediastinum 1814(45)

76 Tumors and Cysts of the Mediastinum 1814(22)

David R. Park

Eric Vallieres

77 Pneumomediastinum and Mediastinitis 1836(23)

David R. Park

Eric Vallieres

Section P Disorders in the Control of Breathing 1859(55)

78 Hypoventilation and Hyperventilation Syndromes 1859(22)

James Duffin

Eliot A. Phillipson

79 Sleep-Disordered Breathing 1881(33)

Grace W. Pien

Allan I. Pack

Section Q Respiratory Manifestations of Extrapulmonary Disorders 1914(170)

80 Pulmonary Complications of Human Immunodeficiency Virus Infection 1914(36)

Kristina Crothers

Alison Morris

Laurence Huang

81 Pulmonary Complications of Stem Cell and Solid Organ Transplantation 1950(13)

Rodney J. Folz

Maria Cirino-Marcano

82 Pulmonary Complications of Primary Immunodeficiencies 1963(19)

John M. Routes

83 Pulmonary Complications of Abdominal Disease 1982(17)

Roberto Rodriguez-Roisin

Joan Albert Barbera

84 Pulmonary Complications of Hematologic Disease 1999(23)

Roberto F. Machado

Mark T. Gladwin

85 Pulmonary Complications of Endocrine Diseases 2022(10)

Leslie Zimmerman

86 The Lungs in Obstetric and Gynecologic Disease 2032(15)

Norman W. Rizk

Stephen E. Lapinsky

87 The Respiratory System and Neuromuscular Diseases 2047(20)

Joshua O. Benditt

F. Dennis McCool

88 The Lungs and Chest Wall Diseases 2067(17)

George E. Tzelepis

F. Dennis McCool

Section R Management of Respiratory Failure 2084

89 Principles of Mechanical Ventilation 2084(20)

Neil R. Maclntyre

90 Acute Respiratory Distress Syndrome 2104(26)

Warren L. Lee

Arthur S. Slutsky

91 Hypoxemic Respiratory Failure 2130(8)

Lorenzo Del Sorbo

Erica L. Martin

V. Marco Ranieri

92 Acute Ventilatory Failure 2138(22)

Nicholas S. Hill

Gregory A. Schmidt

93 Care at the End of Life for Patients with Respiratory Failure 2160(20)

John M. Luce

Douglas B. White

94 Pulmonary Rehabilitation 2180(14)

Bartolome R. Celli

Richard L. ZuWallack

95 Lung Transplantation 2194

Robert M. Kotloff
Appendix Glossary of Terms and Standard Symbols i
Index v

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