Biologically active substances of protozoa /
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作 者：by Natalia N. Sukhareva-Buell.
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ISBN：9781402012815
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简介
Summary:
Publisher Summary 1
In this volume, Sukhareva-Buell (Academy of Technological Sciences of the Russian Federation, Moscow) presents the results of her study on the biologically active substances (BAS) of the Mastigophora (flagellates), highlighting the scientific approaches used to obtain BAS. Chapter topics include toxins and detoxification substances, media for cultivation, conditions for growth, lipids, glycosylated lipids, and surface membrane glycoproteins. Annotation (c) Book News, Inc., Portland, OR (booknews.com)
Publisher Summary 2
This book outlines one of the vast and fruitful fields in protozoan microbiology and formulates the principles of obtaining biologically active substances from cultures of Protozoa. The correlation between composition of selected flagellates' cell components (polyunsaturated fatty acids, membrane surface glycophospolipids, intercellular polysaccharide, beta-1, 3-glycan) and their biological effects in experimental animals, is the main topic of the book. As the book's content shows, the Protozoa are gradually acquiring their place among traditional producers of biologically active substances. The row of producers of BAS can be extended by including non-parasitic representatives of the Protozoa (the phylum Sarcomastigophora). Representatives of the phylum Ciliophora are emerging. This book has been addressed to undergraduate and postgraduate students and young scientists to provide orientation in the field, especially in the sequence of studies which lead to obtaining biologically active substances and primary evaluation of their biological effects. This book may also be of interest to pharmacologists and manufacturers.
目录
Preface p. vii
Acknowledgments p. ix
Introduction p. xi
Protozoa as producers of biologically active substances p. 1
Trypanosoma cruzi as the source of medications; selection of other species among flagellates p. 1
Toxins and detoxification substances p. 4
Biologically active substances of soil Protozoa p. 6
Cultivation of flagellates p. 11
Media for cultivation of flagellates p. 11
Physiological role of main media components in the cultures of flagellates p. 12
Conditions for flagellates growth and stimulated biosynthesis of lipids p. 15
Inoculum quality and quantity p. 18
pH and osmolarity regulation p. 18
Influence of temperature p. 21
Passive and active aeration p. 21
Lipids of flagellates p. 24
Phospholipids and sterols p. 24
Fatty acids and conditions for stimulated biosynthesis p. 28
Biosynthesis of lipids by flagellates p. 31
Glycosylated lipids of flagellates p. 36
Glycosyl-phosphatidylinositol (GPI) and related GIPL, LPG and LPPG p. 37
Biological functions of GPI and related glycophospholipids p. 41
Surface membrane glycoproteins of flagellates p. 46
Variant surface glycoproteins (VSGs) and their genes rearrangement p. 48
Sialic acids and trans-sialidases p. 51
Membrane mucins and mucin-like glycoproteins p. 53
Cytokines, eicosanoids and nitric oxide as effector molecules against parasitic flagellates p. 55
Cytokines p. 55
Eicosanoids p. 59
Nitric oxide p. 64
Biologically active substances of selected flagellates p. 66
Total lipid fraction: correlation between its composition and biological activity p. 66
Astasilid, its composition and biological activity p. 69
Membrane glycophospholipid (GPL) and it's biological activity p. 74
Reserve polysaccharide from Astasia longa and it's biological activity p. 78
Conclusion p. 81
References p. 87
Index p. 107
Acknowledgments p. ix
Introduction p. xi
Protozoa as producers of biologically active substances p. 1
Trypanosoma cruzi as the source of medications; selection of other species among flagellates p. 1
Toxins and detoxification substances p. 4
Biologically active substances of soil Protozoa p. 6
Cultivation of flagellates p. 11
Media for cultivation of flagellates p. 11
Physiological role of main media components in the cultures of flagellates p. 12
Conditions for flagellates growth and stimulated biosynthesis of lipids p. 15
Inoculum quality and quantity p. 18
pH and osmolarity regulation p. 18
Influence of temperature p. 21
Passive and active aeration p. 21
Lipids of flagellates p. 24
Phospholipids and sterols p. 24
Fatty acids and conditions for stimulated biosynthesis p. 28
Biosynthesis of lipids by flagellates p. 31
Glycosylated lipids of flagellates p. 36
Glycosyl-phosphatidylinositol (GPI) and related GIPL, LPG and LPPG p. 37
Biological functions of GPI and related glycophospholipids p. 41
Surface membrane glycoproteins of flagellates p. 46
Variant surface glycoproteins (VSGs) and their genes rearrangement p. 48
Sialic acids and trans-sialidases p. 51
Membrane mucins and mucin-like glycoproteins p. 53
Cytokines, eicosanoids and nitric oxide as effector molecules against parasitic flagellates p. 55
Cytokines p. 55
Eicosanoids p. 59
Nitric oxide p. 64
Biologically active substances of selected flagellates p. 66
Total lipid fraction: correlation between its composition and biological activity p. 66
Astasilid, its composition and biological activity p. 69
Membrane glycophospholipid (GPL) and it's biological activity p. 74
Reserve polysaccharide from Astasia longa and it's biological activity p. 78
Conclusion p. 81
References p. 87
Index p. 107
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