简介
"Nerve and Muscle is an introductory textbook for students taking university courses in physiology, cell biology or preclinical medicine. Previous editions were highly acclaimed as a readable and concise account of how nerves and muscles work. The book begins with a discussion of the nature of nerve impulses. These electrical events can be understood in terms of the flow of ions through molecular channels in the nerve cell membrane. Then the view changes to consideration of synaptic transmission: how one nerve cell can produce changes in another nerve cell or a muscle fibre with which it makes contact. Again ion channels are involved, but now they are opened by special chemicals released from the nerve cell terminals. The final chapters discuss the nature of muscular contraction, including especially the relations between cellular structure and contractile function. This new edition includes much new material, especially on the molecular nature of ion channels and the contractile mechanism of muscle, while retaining a straightforward exposition of the fundamentals of the subject."--BOOK JACKET.
目录
Cover 1
Half-title 3
Series-title 5
Title 7
Copyright 8
Contents 9
Preface 13
Publishers note 14
1 Structural organization of the nervous system 15
Nervous systems 15
The anatomy of a neuron 16
Non-myelinated nerve fibres 17
Myelinated nerve fibres 20
2 Resting and action potentials 25
Electrophysiological recording methods 25
Intracellular recording of the membrane potential 27
Extracellular recording of the nervous impulse 29
Excitation 33
3 The ionic permeability of the nerve membrane 39
Structure of the cell membrane 39
Distribution of ions in nerve and muscle 42
The genesis of the resting potential 45
The Donnan equilibrium system in muscle 47
The active transport of ions 48
4 Membrane permeability changes during excitation 55
The impedance change during the spike 55
The sodium hypothesis 55
Voltage-clamp experiments 61
Patch-clamp studies 71
5 Voltage-gated ion channels 73
cDNA sequencing studies 73
The primary structure of voltage-gated ion channels 75
The sodium gating current 78
The screw-helical mechanism of voltage-gating 80
The ionic selectivity of voltage-gated channels 83
6 Cable theory and saltatory conduction 87
The spread of potential changes in a cable system 87
Saltatory conduction in myelinated nerves 89
Factors affecting conduction velocity 95
Factors affecting the threshold for excitation 96
After-potentials 98
7 Neuromuscular transmission 100
The neuromuscular junction 100
Chemical transmission 101
Postsynaptic responses 103
The end-plate potential 103
Excitation of the muscle fibre 104
The response to acetylcholine 105
Ionic current flow during the end-plate potential 106
Acetylcholine receptors and single channel responses 108
The molecular structure of the acetylcholine receptor 109
Acetylcholinesterase 113
Presynaptic events 113
The quantal release of acetylcholine 113
Depolarization and calcium entry 115
Synaptic delay 115
Facilitation and depression 115
8 Synaptic transmission in the nervous system 117
Synaptic excitation in motoneurons 118
Excitatory postsynaptic potentials 119
Inhibition in motoneurons 121
Interaction of IPSPs with EPSPs 123
Presynaptic inhibition 124
Slow synaptic potentials 124
G-protein-linked receptors 127
Electrotonic synapses 129
9 Skeletal muscles 132
Anatomy 132
Mechanical properties 134
Isometric and isotonic contractions 134
Isometric twitch and tetanus 135
Isotonic contractions 138
Energetics of contraction 141
Work and power 141
Heat production 142
Efficiency 144
The energy source 144
Muscular exercise 146
Muscular fatigue 148
The effects of training 149
10 The mechanism of contraction in skeletal muscle 150
Excitation\u2013contraction coupling 150
Depolarization of the cell membrane 150
Calcium ions 151
Internal membrane systems 152
The structure of the myofibril 157
The sliding filament theory 160
The lengths of the filaments 160
The relation between sarcomere length and isometric tension 161
The molecular basis of contraction 163
Myosin 163
Actin 165
The interaction of actin, myosin and ATP 166
The molecular basis of activation 168
11 Non-skeletal muscles 170
Cardiac muscle 170
The cardiac action potential 170
The spread of excitation 174
The electrocardiogram 175
Excitation\u2013contraction coupling 177
Nervous control of the heart 177
Smooth muscle 178
Excitation 179
Activation 180
Contraction 181
Further reading 182
References 183
Index 189
Half-title 3
Series-title 5
Title 7
Copyright 8
Contents 9
Preface 13
Publishers note 14
1 Structural organization of the nervous system 15
Nervous systems 15
The anatomy of a neuron 16
Non-myelinated nerve fibres 17
Myelinated nerve fibres 20
2 Resting and action potentials 25
Electrophysiological recording methods 25
Intracellular recording of the membrane potential 27
Extracellular recording of the nervous impulse 29
Excitation 33
3 The ionic permeability of the nerve membrane 39
Structure of the cell membrane 39
Distribution of ions in nerve and muscle 42
The genesis of the resting potential 45
The Donnan equilibrium system in muscle 47
The active transport of ions 48
4 Membrane permeability changes during excitation 55
The impedance change during the spike 55
The sodium hypothesis 55
Voltage-clamp experiments 61
Patch-clamp studies 71
5 Voltage-gated ion channels 73
cDNA sequencing studies 73
The primary structure of voltage-gated ion channels 75
The sodium gating current 78
The screw-helical mechanism of voltage-gating 80
The ionic selectivity of voltage-gated channels 83
6 Cable theory and saltatory conduction 87
The spread of potential changes in a cable system 87
Saltatory conduction in myelinated nerves 89
Factors affecting conduction velocity 95
Factors affecting the threshold for excitation 96
After-potentials 98
7 Neuromuscular transmission 100
The neuromuscular junction 100
Chemical transmission 101
Postsynaptic responses 103
The end-plate potential 103
Excitation of the muscle fibre 104
The response to acetylcholine 105
Ionic current flow during the end-plate potential 106
Acetylcholine receptors and single channel responses 108
The molecular structure of the acetylcholine receptor 109
Acetylcholinesterase 113
Presynaptic events 113
The quantal release of acetylcholine 113
Depolarization and calcium entry 115
Synaptic delay 115
Facilitation and depression 115
8 Synaptic transmission in the nervous system 117
Synaptic excitation in motoneurons 118
Excitatory postsynaptic potentials 119
Inhibition in motoneurons 121
Interaction of IPSPs with EPSPs 123
Presynaptic inhibition 124
Slow synaptic potentials 124
G-protein-linked receptors 127
Electrotonic synapses 129
9 Skeletal muscles 132
Anatomy 132
Mechanical properties 134
Isometric and isotonic contractions 134
Isometric twitch and tetanus 135
Isotonic contractions 138
Energetics of contraction 141
Work and power 141
Heat production 142
Efficiency 144
The energy source 144
Muscular exercise 146
Muscular fatigue 148
The effects of training 149
10 The mechanism of contraction in skeletal muscle 150
Excitation\u2013contraction coupling 150
Depolarization of the cell membrane 150
Calcium ions 151
Internal membrane systems 152
The structure of the myofibril 157
The sliding filament theory 160
The lengths of the filaments 160
The relation between sarcomere length and isometric tension 161
The molecular basis of contraction 163
Myosin 163
Actin 165
The interaction of actin, myosin and ATP 166
The molecular basis of activation 168
11 Non-skeletal muscles 170
Cardiac muscle 170
The cardiac action potential 170
The spread of excitation 174
The electrocardiogram 175
Excitation\u2013contraction coupling 177
Nervous control of the heart 177
Smooth muscle 178
Excitation 179
Activation 180
Contraction 181
Further reading 182
References 183
Index 189
- 名称
- 类型
- 大小
光盘服务联系方式: 020-38250260 客服QQ：4006604884
云图客服：
用户发送的提问，这种方式就需要有位在线客服来回答用户的问题，这种 就属于对话式的,问题是这种提问是否需要用户登录才能提问
Video Player
×
Audio Player
×
pdf Player
×
