Quantitative trait loci : methods and protocols /
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作 者：edited by Nicola J. Camp and Angela Cox.
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ISBN：9780896039278
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简介
Presenting statistical methods for the genetic analysis of quantitative traits, 12 contributions review recent methodologies in the areas of human traits underlying disease, experimental organisms as models for human disease, and crop and livestock applications in agriculture. Each chapter examines the steps for proceeding with specific analyses, including discussion of appropriate software, interpretation of results and worked examples. Camp (genetic epidemiology, U. of Utah School of Medicine, US) and Cox (Institute for Cancer Studies, U. of Sheffield Medical School, UK) include examinations of association studies, parametric linkage analysis, join linkage and segregation analysis using Markov chain Monte Carlo methods, experimental designs for qualitative trait locus analysis in mice, and approaches to the analysis of complex quantitative phenotypes and marker map construction based on the analysis of rat models of hypertension. Annotation c. Book News, Inc., Portland, OR (booknews.com)
目录
Dedication p. v
Preface p. vii
Contributors p. xi
Part I Mapping Quantitative Trait Loci in Humans
1 Association Studies Jennifer H. Barrett p. 3
2 Parametric Linkage Analysis Lyle J. Palmer and Audrey H. Schnell and John S. Witte and Robert C. Elston p. 13
3 Nonparametric Linkage Analysis: I. Haseman-Elston Chad P. Garner p. 37
4 Nonparametric Linkage Analysis: II. Variance Components Angela J. Marlow p. 61
5 Linkage and Association: The Transmission/Disequilibrium Test for QTLs Mark M. Iles p. 101
6 Joint Linkage and Segregation Analysis Using Markov Chain Monte Carlo Methods Ellen M. Wijsman p. 139
Part II Mapping Quantitative Trait Loci in Rodents
7 Approaches to the Analysis of QTL Data in Mice, Using the Nonobese Diabetic Mouse as an Example Heather J. Cordell p. 165
8 Experimental Designs for QTL Fine Mapping in Rodents Anne Shalom and Ariel Darvasi p. 199
9 Approaches to the Analysis of Complex Quantitative Phenotypes and Marker Map Construction Based on the Analysis of Rat Models of Hypertension Dominique Gauguier and Nilesh Samani p. 225
10 A Case Study of QTL Analysis in a Mouse Model of Asthma Youming Zhang and William Cookson p. 253
Part III Mapping Quantitative Trait Loci in Agricultural Settings
11 QTL Analysis in Plants Shizhong Xu p. 283
12 QTL Analysis in Livestock Joao L. Rocha and Daniel Pomp and L. Dale Van Vleck p. 311
Index p. 347
Preface p. vii
Contributors p. xi
Part I Mapping Quantitative Trait Loci in Humans
1 Association Studies Jennifer H. Barrett p. 3
2 Parametric Linkage Analysis Lyle J. Palmer and Audrey H. Schnell and John S. Witte and Robert C. Elston p. 13
3 Nonparametric Linkage Analysis: I. Haseman-Elston Chad P. Garner p. 37
4 Nonparametric Linkage Analysis: II. Variance Components Angela J. Marlow p. 61
5 Linkage and Association: The Transmission/Disequilibrium Test for QTLs Mark M. Iles p. 101
6 Joint Linkage and Segregation Analysis Using Markov Chain Monte Carlo Methods Ellen M. Wijsman p. 139
Part II Mapping Quantitative Trait Loci in Rodents
7 Approaches to the Analysis of QTL Data in Mice, Using the Nonobese Diabetic Mouse as an Example Heather J. Cordell p. 165
8 Experimental Designs for QTL Fine Mapping in Rodents Anne Shalom and Ariel Darvasi p. 199
9 Approaches to the Analysis of Complex Quantitative Phenotypes and Marker Map Construction Based on the Analysis of Rat Models of Hypertension Dominique Gauguier and Nilesh Samani p. 225
10 A Case Study of QTL Analysis in a Mouse Model of Asthma Youming Zhang and William Cookson p. 253
Part III Mapping Quantitative Trait Loci in Agricultural Settings
11 QTL Analysis in Plants Shizhong Xu p. 283
12 QTL Analysis in Livestock Joao L. Rocha and Daniel Pomp and L. Dale Van Vleck p. 311
Index p. 347
Quantitative trait loci : methods and protocols /
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