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ISBN:9780387892795

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简介

Dynamic-clamp is a electrophysiology technique that consists of merging living neurons with computational models. This title covers such topics as: the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; and, creating hybrid networks with real and artificial cells.

目录

Front matter 1-30
Associating Living Cells and Computational Models: an Introduction to Dynamic Clamp Principles and its Applications 1-17
Dendritic Dynamic Clamp 鈥?A Tool to Study Single Neuron Computation 1-23
Synaptic Conductances and Spike Generation in Cortical Cells 1-15
Simulating In Vivo Background Activity in a Slice with the Dynamic Clamp 1-26
Impact of Background Synaptic Activity on Neuronal Response Properties Revealed by Stepwise Replication of In Vivo-Like Conditions In Vitro 1-26
Testing Methods for Synaptic Conductance Analysis Using Controlled Conductance Injection with Dynamic Clamp 1-23
In Vivo Dynamic-Clamp Manipulation of Extrinsic and Intrinsic Conductances: Functional Roles of Shunting Inhibition and IBKin Rat and Cat Cortex 1-33
Functions of the Persistent Na+Current in Cortical Neurons Revealed by Dynamic Clamp 1-17
Using 鈥淗ard鈥?Real-Time Dynamic Clamp to Study Cellular and Network Mechanisms of Synchronization in the Hippocampal Formation 1-19
Unraveling the Dynamics of Deep Cerebellar Nucleus Neurons with the Application of Artificial Conductances 1-23
Intrinsic and Network Contributions to Reverberatory Activity: Reactive Clamp and Modeling Studies 1-13
Dynamic-Clamp-Constructed Hybrid Circuits for the Study of Synchronization Phenomena in Networks of Bursting Neurons 1-11
Using the Dynamic Clamp to Explore the Relationship Between Intrinsic Activity and Network Dynamics 1-34
Re-Creating In Vivo-Like Activity and Investigating the Signal Transfer Capabilities of Neurons: Dynamic-Clamp Applications Using Real-Time Neuron 1-25
Using the Dynamic Clamp to Dissect the Properties and Mechanisms of Intrinsic Thalamic Oscillations 1-36
Dynamic Clamp with High-Resistance Electrodes Using Active Electrode Compensation In Vitro and In Vivo 1-15
Key Factors for Improving Dynamic-Clamp Performance 1-17
Development of a Genetically Engineered Cardiac Pacemaker: Insights from Dynamic Action Potential Clamp Experiments 1-13
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