Misbehaving proteins : protein (mis)folding, aggregation, and stability /
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作 者：edited by Regina M. Murphy, Amos M. Tsai.
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ISBN：9780387305080
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简介
Summary:
Publisher Summary 1
This text provides an up-to-date collection of theoretical and experimental studies into protein folding, misfolding, aggregation, and stability. Additionally, issues faced during the development of protein products are illustrated. It contains an introductory chapter for readers new to the protein folding field. The book provides a thorough and clear discussion of computational approaches to understanding and modeling protein aggregation.
目录
Part I Introduction
Protein Folding, Misfolding, Stability, and Aggregation: An Overview Regina M. Murphy and Amos M. Tsai p. 3
Part II Mathematical Models and Computational Methods
Nonnative Protein Aggregation: Pathways, Kinetics, and Stability Prediction Christopher J. Roberts p. 17
Simulations of Protein Aggregation: A Review Carol K. Hall and Hung D. Nguyen and Alexander J. Marchut and Victoria Wagoner p. 47
Part III Experimental Methods
Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry Erik J. Fernandez and Scott A. Tobler p. 81
Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development Angela Wilcox and Rajesh Krishnamurthy p. 99
Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales Susan Krueger and Derek Ho and Amos Tsai p. 125
Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation Regina M. Murphy and Christine C. Lee p. 147
X-Ray Diffraction for Characterizing Structure in Protein Aggregates Hideyo Inouye and Deepak Sharma and Daniel A. Kirschner p. 167
Glass Dynamics and the Preservation of Proteins Christopher L. Soles and Amos M. Tsai and Marcus T. Cicerone p. 193
Part IV Fundamental Studies in Model Systems
Folding and Misfolding as a Function of Polypeptide Chain Elongation: Conformational Trends and Implications for Intracellular Events Silvia Cavagnero and Nese Kurt p. 217
Determinants of Protein Folding and Aggregation in P22 Tailspike Protein Matthew J. Gage and Brian G. Lefebvre and Anne S. Robinson p. 247
Factors Affecting the Fibrillation of [alpha]-Synuclein, a Natively Unfolded Protein Anthony L. Fink p. 265
Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation Lisa A. Kueltzo and C. Russell Middaugh p. 287
Part V Protein Product Development
Self-Association of Therapeutic Proteins: Implications for Product Development Mary E. M. Cromwell and Chantel Felten and Heather Flores and Jun Liu and Steven J. Shire p. 313
Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation: Role of Altered Conformation in Irreversible Precipitation Margaret Speed Ricci and Monica M. Pallitto and Linda Owens Narhi and Thomas Boone and David N. Brems p. 331
Index p. 351
Protein Folding, Misfolding, Stability, and Aggregation: An Overview Regina M. Murphy and Amos M. Tsai p. 3
Part II Mathematical Models and Computational Methods
Nonnative Protein Aggregation: Pathways, Kinetics, and Stability Prediction Christopher J. Roberts p. 17
Simulations of Protein Aggregation: A Review Carol K. Hall and Hung D. Nguyen and Alexander J. Marchut and Victoria Wagoner p. 47
Part III Experimental Methods
Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry Erik J. Fernandez and Scott A. Tobler p. 81
Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development Angela Wilcox and Rajesh Krishnamurthy p. 99
Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales Susan Krueger and Derek Ho and Amos Tsai p. 125
Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation Regina M. Murphy and Christine C. Lee p. 147
X-Ray Diffraction for Characterizing Structure in Protein Aggregates Hideyo Inouye and Deepak Sharma and Daniel A. Kirschner p. 167
Glass Dynamics and the Preservation of Proteins Christopher L. Soles and Amos M. Tsai and Marcus T. Cicerone p. 193
Part IV Fundamental Studies in Model Systems
Folding and Misfolding as a Function of Polypeptide Chain Elongation: Conformational Trends and Implications for Intracellular Events Silvia Cavagnero and Nese Kurt p. 217
Determinants of Protein Folding and Aggregation in P22 Tailspike Protein Matthew J. Gage and Brian G. Lefebvre and Anne S. Robinson p. 247
Factors Affecting the Fibrillation of [alpha]-Synuclein, a Natively Unfolded Protein Anthony L. Fink p. 265
Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation Lisa A. Kueltzo and C. Russell Middaugh p. 287
Part V Protein Product Development
Self-Association of Therapeutic Proteins: Implications for Product Development Mary E. M. Cromwell and Chantel Felten and Heather Flores and Jun Liu and Steven J. Shire p. 313
Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation: Role of Altered Conformation in Irreversible Precipitation Margaret Speed Ricci and Monica M. Pallitto and Linda Owens Narhi and Thomas Boone and David N. Brems p. 331
Index p. 351
Misbehaving proteins : protein (mis)folding, aggregation, and stability /
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