Gene-Environment interactions : fundamentals of ecogenetics /
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作 者：edited by Lucio G. Costa, David L. Eaton.
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ISBN：9780471467816
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简介
Summary:
Publisher Summary 1
Costa and Eaton, both affiliated with the Department of Environmental and Occupational Health Sciences at the University of Washington, present recent work in the field of ecogenetics, the interplay between heredity and the environment. Coverage encompasses both laboratory and data analysis, with special emphasis given to polymorphisms that may predispose individuals to disease. Early chapters cover lab tools for assessing genotypes, and later chapters cover genetic polymorphisms relevant for ecogenetics, common diseases where genetic and environmental factors interact, and ethical, legal, and social issues. Annotation 漏2006 Book News, Inc., Portland, OR (booknews.com)
Publisher Summary 2
Understanding the play between heredity and environment, and relating it to disease causation, is the task of ecogenetics. Gene-Environment Interactions: Fundamentals of Ecogenetics presents the first comprehensive survey of this discipline, reflecting its relationship with toxicology, epidemiology, pharmacology, public health, and other medical and biological fields.
Divided into four sections, the text elucidates key basic and advanced topics:
* Section 1 covers fundamentals, including the history of the discipline, a discussion of the molecular laboratory tools currently available to assess genotypes, using such measurements in molecular epidemiology studies, and the statistical issues involved in their analysis.
* Section 2 focuses on a number of key genetic polymorphisms relevant for ecogenetics, including enzymes of phase I and phase II metabolism, enzymes involved in DNA repair, as well as receptors and ion channels. This highlights characteristics of selected, widely studied genotypic/phenotypic differences, and allows discussion of how given genetic variations can influence responses to exogenous chemicals.
* Section 3 examines gene-environment interactions through a disease-based approach, addressing how genetic polymorphisms can influence susceptibility to various diseases. Chapters cover important disease conditions such as various types of cancer, neurodegenerative diseases, cardiovascular disease, chronic pulmonary diseases, infectious diseases, diabetes, and obesity.
* The final section discusses the ethical, legal, and social issues that arise when investigating and evaluating genetic polymorphisms in human populations, as well as the impact of ecogenetics on risk assessment, regulatory policies, and medicine and public health.
Packed with clear examples illustrating concepts, as well as numerous tables and figures, Gene-Environment Interactions: Fundamentals of Ecogenetics is a unique resource for a wide range of physicians, students, and other specialists.
目录
Foreword p. ix
Acknowledgments p. xi
Contributors p. xiii
Part I
Chapter 1 Introduction Lucio G. Costa and David L. Eaton p. 1
Chapter 2 Ecogenetics: Historical Perspectives Gilbert S. Omenn and Arno G. Motulsky p. 7
Chapter 3 Tools of Ecogenetics Theo K. Bammler and Federico M. Farin and Richard P. Beyer p. 17
Chapter 4 Epidemiologic Approaches Harvey Checkoway and Parveen Bhatti and Anneclaire De Roos p. 51
Chapter 5 Statistical Issues in Ecogenetic Studies Stephanie A. Monks p. 73
Part II
Chapter 6 Overview of Section II Lucio G. Costa and David L. Eaton p. 91
Chapter 7 Polymorphisms in Cytochrome P450 and Flavin- Containing Monooxygenase Genes Catherine K. Yeung and Allan E. Rettie and Kenneth E. Thummel p. 95
Chapter 8 Polymorphisms in Xenobiotic Conjugation Helen E. Smith and David L. Eaton and Theo K. Bammler p. 127
Chapter 9 Paraoxonase, Butyrylcholinesterase, and Epoxide Hydrolase Lucio G. Costa and Toby B. Cole and Gary K. Geiss and Clement E. Furlong p. 159
Chapter 10 DNA Repair Enzymes Jon P. Anderson and Lawrence A. Loeb p. 179
Chapter 11 Receptors and Ion Channels Lucio G. Costa p. 197
Part III
Chapter 12 Overview of Section III Lucio G. Costa and David L. Eaton p. 213
Chapter 13 Lung Cancer Valle Nazar-Stewart p. 215
Chapter 14 Gastrointestinal Cancers Thomas L. Vaughan p. 239
Chapter 15 Neurodegenerative Diseases Samir N. Kelada and Harvey Checkoway and Lucio G. Costa p. 253
Chapter 16 Cardiovascular Disease Melissa A. Austin and Stephen M. Schwartz p. 271
Chapter 17 Type 2 Diabetes Karen L. Edwards p. 285
Chapter 18 Infectious Disease Ecogenetics David R. Sherman p. 303
Chapter 19 Genetic Variation, Diet, and Disease Susceptibility Johanna W. Lampe and John D. Potter p. 321
Chapter 20 Genetic Determinants of Addiction to Alcohol, Tobacco, and Drugs of Abuse Andrew J. Saxon p. 351
Part IV
Chapter 21 Overview of Section IV Lucio G. Costa and David L. Eaton p. 377
Chapter 22 Ethical Issues in Ecogenetics Kelly Fryer-Edwards and Lindsay A. Hampson and Christopher R. Carlsten and Wylie Burke p. 381
Chapter 23 Social and Psychological Aspects of Ecogenetics Deborah Bowen and Shirley Beresford and Brenda Diergaarde p. 397
Chapter 24 Legal Issues Kate Battuello and Anna Mastroianni p. 411
Chapter 25 Risk Assessment and the Impact of Ecogenetics Elaine M. Faustman and Gilbert S. Omenn p. 427
Bibliography p. 451
Index p. 531
Acknowledgments p. xi
Contributors p. xiii
Part I
Chapter 1 Introduction Lucio G. Costa and David L. Eaton p. 1
Chapter 2 Ecogenetics: Historical Perspectives Gilbert S. Omenn and Arno G. Motulsky p. 7
Chapter 3 Tools of Ecogenetics Theo K. Bammler and Federico M. Farin and Richard P. Beyer p. 17
Chapter 4 Epidemiologic Approaches Harvey Checkoway and Parveen Bhatti and Anneclaire De Roos p. 51
Chapter 5 Statistical Issues in Ecogenetic Studies Stephanie A. Monks p. 73
Part II
Chapter 6 Overview of Section II Lucio G. Costa and David L. Eaton p. 91
Chapter 7 Polymorphisms in Cytochrome P450 and Flavin- Containing Monooxygenase Genes Catherine K. Yeung and Allan E. Rettie and Kenneth E. Thummel p. 95
Chapter 8 Polymorphisms in Xenobiotic Conjugation Helen E. Smith and David L. Eaton and Theo K. Bammler p. 127
Chapter 9 Paraoxonase, Butyrylcholinesterase, and Epoxide Hydrolase Lucio G. Costa and Toby B. Cole and Gary K. Geiss and Clement E. Furlong p. 159
Chapter 10 DNA Repair Enzymes Jon P. Anderson and Lawrence A. Loeb p. 179
Chapter 11 Receptors and Ion Channels Lucio G. Costa p. 197
Part III
Chapter 12 Overview of Section III Lucio G. Costa and David L. Eaton p. 213
Chapter 13 Lung Cancer Valle Nazar-Stewart p. 215
Chapter 14 Gastrointestinal Cancers Thomas L. Vaughan p. 239
Chapter 15 Neurodegenerative Diseases Samir N. Kelada and Harvey Checkoway and Lucio G. Costa p. 253
Chapter 16 Cardiovascular Disease Melissa A. Austin and Stephen M. Schwartz p. 271
Chapter 17 Type 2 Diabetes Karen L. Edwards p. 285
Chapter 18 Infectious Disease Ecogenetics David R. Sherman p. 303
Chapter 19 Genetic Variation, Diet, and Disease Susceptibility Johanna W. Lampe and John D. Potter p. 321
Chapter 20 Genetic Determinants of Addiction to Alcohol, Tobacco, and Drugs of Abuse Andrew J. Saxon p. 351
Part IV
Chapter 21 Overview of Section IV Lucio G. Costa and David L. Eaton p. 377
Chapter 22 Ethical Issues in Ecogenetics Kelly Fryer-Edwards and Lindsay A. Hampson and Christopher R. Carlsten and Wylie Burke p. 381
Chapter 23 Social and Psychological Aspects of Ecogenetics Deborah Bowen and Shirley Beresford and Brenda Diergaarde p. 397
Chapter 24 Legal Issues Kate Battuello and Anna Mastroianni p. 411
Chapter 25 Risk Assessment and the Impact of Ecogenetics Elaine M. Faustman and Gilbert S. Omenn p. 427
Bibliography p. 451
Index p. 531
Gene-Environment interactions : fundamentals of ecogenetics /
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