Comparative toxicogenomics / 1st ed.
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作 者：edited by Christer Hogstrand and Peter Kille.
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ISBN：9780444532749
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简介
Toxicogenomics analyses the activity of a particular toxin or chemical substance on living tissue based upon a profiling of its known effects on genetic material. Toxicogenomics is important because it may enhance understanding of mechanisms of toxicity, cellular defence systems, and drug action. If this technique is proven to work, it could be used in a similar way for toxicology and toxin-determination to DNA-testing in the forensic identification of individuals.
Comparative Toxicogenomics provides a timely overview of current achievements and future areas of development including a review of some of the first really fruitful studies made in this area.
* Provides a review of some of the first really fruitful studies made in this area.
* Covers different organisms ranging from humans to model species and environmental sentinels so researchers can see how this technique has been used across different organisms and compare the results of each.
* The chapters transect research interests from identification of toxic action to environmental monitoring providing a broad view of the area increasing its attractiveness to researchers working in a variety of specialties.
目录
Table Of Contents:
Information about the Society for Experimental Biology (SEB) v
Editorial Board vii
Information about the Series Editors ix
Information about the Volume Editors xi
List of Contributors xiii
Preface xvii
1. Toxicogenomics: unlocking the potential of the human genome
Eugene P. Halligan and Joseph Lunec 1
2. Progress in ecotoxicogenomics for environmental monitoring, mode of action, and toxicant identification
Helen C. Poynton, Henri Wintz and Chris D. Vulpe 21
3. Fish toxicogenomics
Charles R. Tyler, Amy L. Filby, Ronny van Aerle, Anke Lange, Jonathan Ball and Eduarda M. Santos 75
4. Current research in soil invertebrate ecotoxicogenomics
David J. Spurgeon, A. John Morgan and Peter Kille 133
5. Daphnia as an emerging model for toxicological genomics
Joseph R. Shaw, Michael E. Pfrender, Brian D. Eads, Rebecca Klaper, Amanda Callaghan, Richard M. Sibly, Isabelle Colson, Bastiaan Jansen, Donald Gilbert and John K. Colbourne 165
6. Whole genome microarray analysis of the expression profile of Escherichia coli in response to exposure to para-nitrophenol
Angela Brown, Jason R. Snape, Colin R. Harwood and Ian M. Head 221
7. Systems toxicology: using the systems biology approach to-assess chemical pollutants in the environment
Richard D. Handy 249
Index of Authors 283
Subject Index 319
Information about the Society for Experimental Biology (SEB) v
Editorial Board vii
Information about the Series Editors ix
Information about the Volume Editors xi
List of Contributors xiii
Preface xvii
1. Toxicogenomics: unlocking the potential of the human genome
Eugene P. Halligan and Joseph Lunec 1
2. Progress in ecotoxicogenomics for environmental monitoring, mode of action, and toxicant identification
Helen C. Poynton, Henri Wintz and Chris D. Vulpe 21
3. Fish toxicogenomics
Charles R. Tyler, Amy L. Filby, Ronny van Aerle, Anke Lange, Jonathan Ball and Eduarda M. Santos 75
4. Current research in soil invertebrate ecotoxicogenomics
David J. Spurgeon, A. John Morgan and Peter Kille 133
5. Daphnia as an emerging model for toxicological genomics
Joseph R. Shaw, Michael E. Pfrender, Brian D. Eads, Rebecca Klaper, Amanda Callaghan, Richard M. Sibly, Isabelle Colson, Bastiaan Jansen, Donald Gilbert and John K. Colbourne 165
6. Whole genome microarray analysis of the expression profile of Escherichia coli in response to exposure to para-nitrophenol
Angela Brown, Jason R. Snape, Colin R. Harwood and Ian M. Head 221
7. Systems toxicology: using the systems biology approach to-assess chemical pollutants in the environment
Richard D. Handy 249
Index of Authors 283
Subject Index 319
Comparative toxicogenomics / 1st ed.
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