International review of cell and molecular biology. V.275 /

Contributors p. vii
1 Cell and Molecular Biology of Invadopodia Giusi Caldieri and Inmaculada Ayala and Francesca Attanasio and Roberto Buccione p. 1
1 Introduction p. 2
2 Biogenesis, Molecular Components, and Activity p. 3
3 Open Questions and Concluding Remarks p. 23
References p. 25
2 Viral Channel-Forming Proteins Wolfgang B. Fischer and Jens Kruger p. 35
1 Introduction p. 36
2 Channel-Forming Proteins p. 37
3 Detecting a Channel-Forming Protein p. 44
4 Functional and Structural Characterization p. 47
5 Channel-Forming Proteins in Antiviral Therapy p. 51
6 Concluding Remarks p. 53
References p. 54
3 Notch Signaling in Chondrogenesis Camilla Karlsson and Anders Lindahl p. 65
1 Introduction p. 66
2 Helix-Loop-Helix Proteins p. 66
3 Notch Genes p. 69
4 Notch1 as a Marker for Progenitor Cells in Adult Cartilage p. 72
5 Function of Notch Signaling During Chondrogenesis p. 74
6 Notch Signaling in Osteoarthritis p. 79
7 Concluding Remarks p. 82
References p. 83
4 The Controversial Role of Mast Cells in Tumor Growth Domenico Ribatti and Enrico Crivellato p. 89
1 Introduction p. 90
2 Biological Functions of Mast Cells p. 91
3 Mast Cell Development, Anatomical Distribution, and Phenotype p. 98
4 Mast Cell-Derived Secretory Products p. 102
5 Mast Cells in Experimental Carcinogenesis p. 106
6 Mast Cells and Tumor Growth in Humans: Pro and Contra p. 107
7 Mast Cells and Tumor Angiogenesis and Lymphangiogenesis p. 111
8 Concluding Remarks p. 118
References p. 119
5 Limbal Stem Cells: Application in Ocular Biomedicine Geeta K. Vemuganti and Anees Fatima and Soundarya Lakshmi Madhira and Surendra Basti and Virender S. Sangwan p. 133
1 Introduction p. 134
2 Ocular Surface and Limbal Stem Cells p. 135
3 Conventional Treatment Modalities of Limbal Stem Cell Deficiency p. 140
4 Concept of Cultivated Limbal Stem Cell Transplantation p. 144
5 Review of Literature on Clinical Trials p. 167
6 Concluding Remarks p. 171
References p. 172
6 Cell and Molecular Biology of the Novel Protein Tyrosine-Phosphatase-Interacting Protein 51 Albrecht Stenzinger and Dietmar Schreiner and Philipp Koch and Hans-Werner Hofer and Monika Wimmer p. 183
1 Introduction p. 184
2 Molecular Biology of PTPIP51 p. 184
3 Signaling Partners of PTPIP51 p. 193
4 Expression Profile of PTPIP51 p. 208
5 Conclusions and Further Perspective p. 226
References p. 227
Index p. 247