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ISBN:9780824704094

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简介

Summary: Publisher Summary 1 Gremlich (Optical Spectroscopy Laboratory, Novartis Pharma AG) and Yan (analytical chemistry, ChemRx Advanced Technologies, Inc.) supply chemical and structural information for identifying and characterizing biological molecules. The 13 contributions provide a thorough introduction to the new methodologies in infrared and Raman instrumentation as well as to their biological applications for future use in both academic and industrial environments. They integrate the biological targets with research experience in order to discuss topics such as the variety of uses for vibrational optical activity and vibrational spectroscopic mapping and imaging; clinical applications; the advantages obtained by time-resolved step scan, surface-enhanced, and imaging approaches; the latest software developments affecting biomedical diagnosis, such as artificial neural networks; and others. Contains b&w and color images and diagrams. Annotation c. Book News, Inc., Portland, OR (booknews.com)  

目录

Preface p. iii
Contributors p. vii
1. Historical Survey of Infrared and Raman Spectroscopy of Biological Materials Henry H. Mantsch p. 1
2. Biological and Pharmaceutical Applications of Vibrational Optical Activity Laurence A. Nafie and Teresa B. Freedman p. 15
3. Vibrational Circular Dichroism of Peptides and Proteins: Survey of Techniques, Qualitative and Quantitative Analyses, and Applications Timothy A. Keiderling p. 55
4. Biological Applications of Infrared Microspectroscopy David L. Wetzel and Steven M. LeVine p. 101
5. Biophysical Infrared Modulation Spectroscopy Urs P. Fringeli and Hans H. Gunthard and Dieter Baurecht p. 143
6. Time-Resolved FT-IR Difference Spectroscopy: A Tool to Monitor Molecular Reaction Mechanisms of Proteins Klaus Gerwert p. 193
7. Biological Vibrational Spectroscopic Imaging Michael D. Schaeberle and Ira W. Levin and E. Neil Lewis p. 231
8. Clinical Applications of Near- and Mid-Infrared Spectroscopy H. Michael Heise p. 259
9. FT-Infrared and FT-Raman Spectroscopy in Biomedical Research Dieter Naumann p. 323
10. Use of Artificial Neural Networks in Biomedical Diagnosis Juergen Schmitt and Thomas Udelhoven p. 379
11. Biological Applications of Raman Spectroscopy H. G. M. Edwards and E. A. Carter p. 421
12. Vibrational Studies of Enzymatic Catalysis Hua Deng and Robert Callender p. 477
13. Infrared and Raman Spectroscopy and Chemometrics of Biological Materials Yukihiro Ozaki and Koichi Murayama p. 515
Index p. 567

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