Contributors p. x
Preface to the First Edition p. xvi
Preface to the Third Edition p. xvii
Glossary p. xviii
Volume 1
Part A Structure and Function
1 Structure
1.1 Anatomy of the thorax R Alistair L Brewis and F Elizabeth White p. 3
1.2 Microscopic structure of the lung Peter K Jeffery p. 34
1.3 Embryology and growth Peter K Jeffery and Alison A Hislop p. 51
1.4 Molecular basis of lung development Jacques Bourbon and Alexandra Henrion-Caude and Claude Gaultier p. 64
2 Function
2.1 Matrix proteins Sarah E Dunsmore and Rachel C Chambers and Geoffrey J Laurent p. 82
2.2 Pulmonary surfactant and lung fluid balance Jens M Hohlfeld p. 93
2.3 Mechanics of ventilation Vito Brusasco and Riccardo Pellegrino p. 105
2.4 Respiratory muscle function Andre de Troyer p. 119
2.5 Pulmonary gas exchange Roberto Rodriguez-Roisin p. 130
2.6 Pulmonary circulation Robert Naeije p. 147
2.7 Respiratory function during exercise Josep Roca and Roberto A Rabinovich p. 158
2.8 Control of breathing Hans Folgering p. 170
3 Respiratory defences
3.1 Physical defences Stewart Clarke and Malcolm King p. 181
3.2 Defence properties of airway surface liquid Edith Puchelle and Sophie de Bentzmann and Jean-Marie Zahm and Jacky Jacquot p. 194
3.3 Immunology of the lung Carlo Agostini and Gianpietro Semenzato p. 205
3.4 Antiproteinases and antioxidants Robert A Stockley p. 222
3.5 Lung inflammation and repair Christopher Haslett p. 233
Part B Symptoms and Signs
4 Clinical assessment John Earis p. 255
5 An approach to common respiratory symptoms
5.1 Cough Lorcan McGarvey and Joseph MacMahon p. 272
5.2 Haemoptysis Michael G Pearson and John Corless p. 278
5.3 Breathlessness Paul W Jones p. 285
5.4 Chest pain Pallav L Shah p. 291
Part C Principles of Diagnosis and Treatment
6 Respiratory function tests G John Gibson p. 299
7 Imaging
7.1 Thoracic imaging David M Hansel p. 316
7.2 Scintigraphic imaging Antonio Palla and Carlo Giuntini p. 352
7.3 Ultrasound of the lung and pleura Angelika Reissig and Claus Kroegel p. 370
8 Laboratory methods
8.1 Bacteriology Roger Freeman p. 378
8.2 Detection of respiratory viruses Paul Taylor and Sebastian L Johnston p. 385
8.3 Cytopathology Jennifer A Young p. 391
8.4 Histopathology methods Richard L Attanoos and Allen R Gibbs p. 397
9 Non-invasive assessment of inflammation Andrew M Zurek and Peter J Sterk and Ratko Djukanovic p. 402
10 Invasive techniques
10.1A Diagnostic bronchoscopy Karl Haussinger and Martin J Kohlhauffl and Chris T Bolliger p. 415
10.1B Therapeutic bronchoscopy Chris T Bolliger and Karl Haussinger p. 431
10.2 Bronchoalveolar lavage Ulrich Costabel and Josune Guzman p. 438
10.3 Percutaneous needle biopsy Fergus Gleeson p. 449
10.4 Thoracoscopy and pleural investigations Robert Loddenkemper and Wolfgang Frank p. 458
11 Principles of thoracic surgery Peter Goldstraw p. 466
12 Lung transplantation John H Dark and Paul A Corris p. 485
13 Principles of oxygen therapy Jean-Louis Pepin and Patrick Levy p. 502
14 Respiratory intensive care Spyros G Zakynthinos and Charis S Roussos p. 522
15 Principles of non-invasive ventilatory support Mark W Elliott p. 541
16 Principles of physiotherapy Rik Gosselink p. 554
17 Pulmonary rehabilitation Nicolino Ambrosino p. 563
18 Assessment for anaesthesia with respiratory disease Brian F Keogh and Caroline J Bateman p. 571
19 Principles of inhaled therapy Eric Derom p. 589
20 Genetics and gene therapy Duncan M Geddes p. 607
Part D Developmental Abnormalities
21 Malformations Andrew Bush p. 613
22 Bronchopulmonary dysplasia Anne Greenough p. 637
Part E Environmental Problems and Lung Injury
23 Air pollution Thomas Sandstrom and Anders Blomberg and Ragnberth Helleday p. 649
24 Smoking John F Golding p. 659
25 Pneumoconiosis Maurits Demedts and Benoit Nemery and Peter C Elmes p. 675
26 Respiratory disease in coal miners Benoit Wallaert p. 693
27 Asbestos-related disease Robin M Rudd p. 707
28 Acute respiratory distress syndrome Mark J D Griffiths and Timothy W Evans p. 736
29 Iatrogenic respiratory disease Philippe Camus and G John Gibson p. 764
30 Toxic lung injury: inhaled agents David J Hendrick p. 807
31 Toxic lung injury: ingested agents Peter G Blain p. 825
32 Humidifier fever P Sherwood Burge p. 837
33 Respiratory problems in adverse environments David M Denison p. 841
34 Near drowning Mark Harries p. 854
Part F Respiratory Infections
35 Pneumonia and other acute respiratory infections John T Macfarlane and Anne Thomson p. 861
36 Respiratory disease in the immunocompromised host
36.1 Pulmonary complications of HIV infection Giovanni Guaraldi and Elisa Busi Rizzi and Cesare Saltini p. 900
36.2 Respiratory disease in the immunocompromised host: non-AIDS Rudolph Speich p. 916
37 Lung abscess John Moore-Gillon and Susannah J Eykyn p. 932
38 Tuberculosis
38.1 Epidemiology of tuberculosis Hans L Rieder p. 938
38.2 Clinical features and management of tuberculosis L Peter Ormerod p. 944
38.3 The control of tuberculosis Peter D O Davies p. 966
39 Opportunistic mycobacterial infections Ian A Campbell and Peter A Jenkins p. 976
40 Bronchopulmonary aspergillosis Douglas Robinson and Patrick Flood-Page p. 986
41 Infections due to dimorphic pathogenic fungi--Histoplasma, Coccidioides, Blastomyces, Paracoccidioides and Penicillium marneffei Roderick J Hay p. 1011
42 Parasitic diseases Nicolas Roche and Gerard Huchon p. 1020
Volume 2
Part G Airway Disorders
43 Diseases of the nose Stephen R Durham and Ian S Mackay p. 1035
44 Diseases of the upper airway Martin R Hetzel p. 1048
45 Obstructive sleep apnoea and related syndromes John Stradling p. 1068
46 Classification of diffuse airway obstruction Romain Pauwels p. 1102
47 Chronic obstructive pulmonary disease (COPD)
47.1 Epidemiology and natural history of chronic obstructive pulmonary disease Dirkje S Postma and Huib A M Kerstjens p. 1109
47.2 Aetiology and pathogenesis of chronic obstructive pulmonary disease William MacNee p. 1121
47.3 Pathology of chronic obstructive pulmonary disease Peter K Jeffery and Marina Saetta p. 1141
47.4 Pathophysiology of chronic obstructive pulmonary disease Dan C Stanescu and Neil B Pride p. 1155
47.5 Clinical features of chronic obstructive pulmonary disease Nikolaus Konietzko p. 1171
47.6 Management of chronic obstructive pulmonary disease Peter M A Calverley p. 1184
48 Asthma
48.1 Epidemiology and natural history of asthma Peter Burney p. 1202
48.2 Pathogenesis of asthma Peter J Barnes and Ratko Djukanovic and Stephen T Holgate p. 1212
48.3 Pathology of asthma Peter K Jeffrey and Bryan Corrin p. 1265
48.4 Pathophysiology of asthma Peter J Sterk and Roberto Rodriguez-Roisin p. 1278
48.5 Prevention of asthma Adnan Custovic and Ashley Woodcock p. 1295
48.6 Diagnosis and assessment of asthma Richard Beasley and Ian Town and Penny Fitzharris p. 1306
48.7 Management and treatment of asthma Anne E Tattersfield and Timothy W Harrison p. 1323
48.8 Difficult to manage asthma Elisabeth H D Bel and Anneke ten Brinke p. 1348
48.9 Asthma: communication and education Martyn R Partridge p. 1357
48.10 New perspectives in asthma treatment Dunja T Schmidt and Klaus F Rabe p. 1367
48.11 Acute severe asthma Brian D W Harrison p. 1378
48.12 Childhood asthma and other wheezing disorders Andrew Bush and John Price p. 1396
48.13 Occupational asthma and byssinosis P Sherwood Burge and Wasif Anees p. 1421
49 Bronchiectasis Robert Wilson p. 1445
50 Cystic fibrosis
50.1 Epidemiology and pathogenesis of cystic fibrosis Gerd Doring p. 1465
50.2 Cystic fibrosis in childhood Andrew Bush and Jane C Davies p. 1477
50.3 Cystic fibrosis in adults: respiratory disease Dennis J Shale p. 1495
50.4 Cystic fibrosis in adults: non-respiratory disease J Stuart Elborn p. 1513
51 Bronchiolitis Venerino Poletti and Marco Chilosi and Maurizio Zompatori p. 1526
Part H Interstitial Lung Disease
52 Diffuse lung diseases: classification and diagnostic approach Roland M du Bois and Ulrich Costabel p. 1545
53 Idiopathic pulmonary fibrosis and related disorders Nicole S L Goh and Roland M du Bois p. 1557
54 Cryptogenic organising pneumonia (bronchiolitis obliterans organising pneumonia) Jean-Francois Cordier and Vincent Cottin p. 1581
55 Extrinsic allergic alveolitis Claus Vogelmeier p. 1591
56 Sarcoidosis Anders Eklund and Johan Grunewald p. 1603
57 Wegener's granulomatosis and other vasculitides Carol A Langford and Ulrich Specks p. 1621
58 Eosinophilic pneumonia Claus Kroegel and Angelika Reissig and Bettina Mock p. 1643
59 Pulmonary Langerhans cell granulomatosis Ulrich Costabel and Bryan Corrin p. 1660
60 Lymphangioleiomyomatosis Simon Johnson p. 1668
61 Alveolar proteinosis Ulrich Costabel and Bryan Corrin p. 1676
62 Other rare parenchymal lung disorders Bryan Corrin and Ulrich Costabel p. 1683
63 Lymphoproliferative disease Andrew G Nicholson and Venerino Poletti and Gianpietro Semenzato p. 1694
Part I Pulmonary Vascular Disease
64 Pulmonary embolic disease Martin Riedel p. 1711
65 Pulmonary hypertension Andrew J Peacock p. 1759
66 Pulmonary arteriovenous malformations and pulmonary artery aneurysms Claire L Shovlin and James E Jackson p. 1773
Part J Respiratory Neoplasms
67 Classification and pathology of bronchopulmonary carcinoma and of metastases in the lung Bryan Corrin p. 1789
68 Epidemiology and screening Halla Skuladottir and Jorgen H Olsen p. 1803
69 Aetiology and pathogenesis of carcinoma of the lung Elisabeth Brambilla and Bryan Corrin p. 1819
70 Clinical features and assessment of lung cancer Stephen G Spiro p. 1828
71 Management of bronchopulmonary cancer Martin F Muers p. 1850
72 Rare tumours of the lung Bryan Corrin p. 1872
Part K Extrapulmonary Disorders
73 Disorders of the thoracic skeleton John M Shneerson p. 1883
74 Chest trauma: current optimum management Alistair N J Graham and Kieran G McManus and James A McGuigan p. 1895
75 Pleural disease Robert Loddenkemper and Wolfgang Frank p. 1907
76 Mediastinal disorders
76.1 Mediastinal masses Peter Goldstraw p. 1938
76.2 Other mediastinal disorders Christopher R Swinburn p. 1959
Part L Respiratory Effects of Systemic Disease
77 Respiratory effects of systemic disease
77.1 Cardiovascular diseases Otto C Burghuber p. 1965
77.2 Renal disease Wilfried De Backer and Paul Vermeire p. 1975
77.3 Blood disorders Christopher C Evans p. 1984
77.4 Gastrointestinal, hepatic and pancreatic diseases Martin F Muers p. 1991
77.5 Neuromuscular diseases Michael I Polkey p. 2010
77.6 Metabolic, endocrine, obstetric and gynaecological conditions Christopher C Evans p. 2024
77.7 Rheumatic and connective tissue disorders Christopher C Evans p. 2029
Index to Volumes 1 and 2 p. il